OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed CUBANS

PLoS Pathogens

Volumn 13, Issue 2, 2017, Pages

  Sierra, Beatriz ^a   Triska, Petr ^b,c   Soares, Pedro ^c   Garcia, Gissel ^a   Perez, Ana B ^a   Aguirre, Eglys ^a   Oliveira, Marisa ^b,c,d   Cavadas, Bruno ^b,c   Regnault, Béatrice ^d   Alvarez, Mayling ^a   Ruiz, Didye ^a   Samuels, David C ^e   Sakuntabhai, Anavaj ^d   Pereira, Luisa ^b,c,f   Guzman, Maria G ^a  

^a INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d INSTITUT PASTEUR   (France)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; COLLAGEN TYPE 5; FICOLIN; MESSENGER RNA; OXYSTEROL BINDING BROTEIN LIKE 10; PROTEIN; RETINOID X RECEPTOR ALPHA; SHORT HAIRPIN RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; OXYSTEROL BINDING PROTEIN; STEROID RECEPTOR;

ARTICLE; BLACK PERSON; COHORT ANALYSIS; CONTROLLED STUDY; CUBA; CUBAN; CYTOKINE PRODUCTION; DENGUE; DENGUE VIRUS; DENGUE VIRUS 2; DISEASE COURSE; DISEASE SEVERITY; ETHNIC DIFFERENCE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NONHUMAN; OXYSTEROL BINDING PROTEIN LIKE 10 GENE; POPULATION STRUCTURE; REAL TIME POLYMERASE CHAIN REACTION; RETINOID X RECEPTOR ALPHA GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS LOAD; DNA MICROARRAY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; POLYMERASE CHAIN REACTION; SEVERE DENGUE;

AFRICAN CONTINENTAL ANCESTRY GROUP; CUBA; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LIPID METABOLISM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, STEROID; RETINOID X RECEPTOR ALPHA; SEVERE DENGUE;

EID: 85014104562     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006220     Document Type: Article

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