The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors

Angewandte Chemie - International Edition

Volumn 56, Issue 14, 2017, Pages 3940-3944

  Nguyen, T Vu ^a   Blackledge, Meghan S ^b   Lindsey, Erick A ^a   Minrovic, Bradley M ^a   Ackart, David F ^c   Jeon, Albert B ^c   Obregón Henao, Andrés ^c   Melander, Roberta J ^a   Basaraba, Randall J ^c   Melander, Christian ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b HIGH POINT UNIVERSITY   (United States)

^c Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

aminobenzimidazoles; antibiotic resistance; medicinal chemistry; tuberculosis

Indexed keywords

BACTERIA; LEAD COMPOUNDS;

AMINOBENZIMIDAZOLES; ANTIBIOTIC RESISTANCE; INTRINSIC RESISTANCE; MECHANISTIC STUDIES; MEDICINAL CHEMISTRY; MULTIDRUG RESISTANTS; MYCOBACTERIUM SMEGMATIS; TUBERCULOSIS;

ANTIBIOTICS;

2-AMINOBENZIMIDAZOLE; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; LACTAM;

CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; DRUG DISCOVERY; LACTAMS; MOLECULAR STRUCTURE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 85014024581     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201612006     Document Type: Article

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