Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens

Journal of Medicinal Chemistry

Volumn 57, Issue 17, 2014, Pages 7450-7458

  Brackett, Christopher M ^a   Melander, Roberta J ^a   An, Il Hwan ^a   Krishnamurthy, Aparna ^a   Thompson, Richele J ^a   Cavanagh, John ^a   Melander, Christian ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CARBAPENEM; CEFTAZIDIME; IMIDAZOLE DERIVATIVE; IMIPENEM; MEROPENEM; MOLECULAR LIBRARY;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PHYSICAL CHEMISTRY; PSEUDOMONAS AERUGINOSA; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CLASSIFICATION; CYTOLOGY; DRUG EFFECTS; HEMOLYSIS; HUMAN; KERATINOCYTE; MICROBIAL SENSITIVITY TEST; MOLECULAR LIBRARY; PHARMACOLOGY; SHEEP;

ANIMALS; BETA-LACTAM RESISTANCE; CELL LINE; CELL SURVIVAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; HEMOLYSIS; HUMANS; KERATINOCYTES; MICROBIAL SENSITIVITY TESTS; SHEEP; SMALL MOLECULE LIBRARIES;

EID: 84907185153     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501050e     Document Type: Article

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