Small molecule downregulation of PmrAB reverses lipid a modification and breaks colistin resistance

ACS Chemical Biology

Volumn 9, Issue 1, 2014, Pages 122-127

  Harris, Tyler L ^a   Worthington, Roberta J ^a   Hittle, Lauren E ^b   Zurawski, Daniel V ^c   Ernst, Robert K ^b   Melander, Christian ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; ETHANOLAMINE PHOSPHOTRANSFERASE; LIPID A; PHOSPHOETHANOLAMINE; PROTEIN HISTIDINE KINASE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BROTH DILUTION; CHEMICAL MODIFICATION; DOWN REGULATION; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COLISTIN; DOWN-REGULATION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; LIPID A; SMALL MOLECULE LIBRARIES; TRANSCRIPTION FACTORS;

EID: 84900443098     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400490k     Document Type: Article

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