Predicting human olfactory perception from chemical features of odor molecules

Science

Volumn 355, Issue 6327, 2017, Pages 820-826

  Keller, Andreas ^a   Gerkin, Richard C ^b   Guan, Yuanfang ^c   Dhurandhar, Amit ^d   Turu, Gabor ^e   Szalai, Bence ^e   Mainland, Joel D ^f,g   Ihara, Yusuke ^f,h   Yu, Chung Wen ^f   Wolfinger, Russ ⁱ   Vens, Celine ^j   Schietgat, Leander ^j   De Grave, Kurt ^j,k   Norel, Raquel ^d   Stolovitzky, Gustavo ^d,m   Cecchi, Guillermo A ^d   Vosshall, Leslie B ^a,l   Meyer, Pablo ^d,m   Bhondekar, A P ⁿ   Boutros, P C ⁿ   Chang, Y C ⁿ   Chen, C Y ⁿ   Cherng, B W ⁿ   Dimitriev, A ⁿ   Dolenc, A ⁿ   Falcao, A O ⁿ   Golinska A K ⁿ   Hong, M Y ⁿ   Hsieh, P H ⁿ   Huang, B F ⁿ   Hunyady, L ⁿ   Kaur, R ⁿ   Kazanov, M D ⁿ   Kumar, R ⁿ   Lesinski W ⁿ   Lin, X ⁿ   Matteson, A ⁿ   Oyang, Y J ⁿ   Panwar, B ⁿ   Piliszek, R ⁿ   Polewko Klim, A ⁿ   Raghava, G P S ⁿ   Rudnicki, W R ⁿ   Saiz, L ⁿ   Sun, R X ⁿ   Toplak, M ⁿ   Tung, Y A ⁿ   Us, P ⁿ   Varnai P ⁿ   Vilar, JMG ⁿ   Xie, M ⁿ   Yao, D ⁿ   Zitnik, M ⁿ   Zupan, B ⁿ   more..

^a ROCKEFELLER UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d IBM   (United States)

^e SEMMELWEIS UNIVERSITY   (Hungary)

^f MONELL CHEMICAL SENSES CENTER   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h AJINOMOTO CO INC   (Japan)

ⁱ SAS INSTITUTE INC   (United States)

^j UNIVERSITY OF LEUVEN   (Belgium)

^k FLANDERS MAKE   (Belgium)

^l HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^m MOUNT SINAI SCHOOL OF MEDICINE   (United States)

ⁿ Icahn School of Medicine at Mount Sinai ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; BIOINFORMATICS; DATA SET; NUMERICAL METHOD; ODOR; OLFACTION; OLFACTORY CUE; PERCEPTION;

ARTICLE; CHEMICAL STRUCTURE; HUMAN; MEDICAL LITERATURE; ODOR; PREDICTION; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; RANDOM FOREST; SMELLING; ADULT; BIOLOGICAL MODEL; INFORMATION PROCESSING; MALE;

ALLIUM SATIVUM;

FRAGRANCE;

ADULT; DATASETS AS TOPIC; HUMANS; MALE; MODELS, BIOLOGICAL; ODORANTS; OLFACTORY PERCEPTION; SMELL;

EID: 85013999403     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aal2014     Document Type: Article

References (19)

1. H. Boelens, Trends Pharmacol. Sci. 4, 421-426 (1983).
2. C. Sell, Angew. Chem. Int. Ed. 45, 6254-6261 (2006).
3. A. A. Koulakov, B. E. Kolterman, A. G. Enikolopov, D. Rinberg, Front. Syst. Neurosci. 5, 65 (2011).
4. J. B. Castro, A. Ramanathan, C. S. Chennubhotla, PLOS ONE 8, e73289 (2013).
5. M. Laska, P. Teubner, Chem. Senses 24, 263-270 (1999).
6. S. Boesveldt, M. J. Olsson, J. N. Lundström, Behav. Brain Res. 215, 110-113 (2010).
7. P. A. Edwards, P. C. Jurs, Chem. Senses 14, 281-291 (1989).
8. R. M. Khan et al., J. Neurosci. 27, 10015-10023 (2007).
9. F. Kermen et al., Sci. Rep. 1, 206 (2011).
10. M. Zarzo, Sensors (Basel) 11, 3667-3686 (2011).
11. K. Snitz et al., PLOS Comput. Biol. 9, e1003184 (2013).
12. A. Dravnieks, Science 218, 799-801 (1982).
13. A. Dravnieks, Atlas of Odor Character Profiles (ASTM, Philadelphia, 1985).
14. A. Keller, L. B. Vosshall, BMC Neurosci. 17, 55 (2016).
15. R. J. Prill, R. Vogel, G. A. Cecchi, G. Altan-Bonnet, G. Stolovitzky, PLOS ONE 10, e0125777 (2015).
16. D. Rogers, M. Hahn, J. Chem. Inf. Model. 50, 742-754 (2010).
17. F. Costa, K. De Grave, in Proceedings of the 26th International Conference on Machine Learning, Montreal, Quebec, Canada, 14 to 18 June 2009 (Association for Computing Machinery, New York, 2010), pp. 255-262.
18. U.S. Environmental Protection Agency, Estimation Programs Interface Suite for Microsoft Windows (EPI Suite), v 4.11 (EPA, Washington, DC, 2014).
19. P. Gupta, D. F. Albeanu, U. S. Bhalla, Nat. Neurosci. 18, 272-281 (2015).