Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

Neuron

Volumn 93, Issue 4, 2017, Pages 882-896.e5

  Cao, Mian ^a   Wu, Yumei ^a   Ashrafi, Ghazaleh ^b   McCartney, Amber J ^a   Wheeler, Heather ^a   Bushong, Eric A ^c   Boassa, Daniela ^c   Ellisman, Mark H ^c,d   Ryan, Timothy A ^b   De Camilli, Pietro ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

auxilin; LRRK2; neurodegeneration; nigrostriatal pathway; PARK19; PARK2; PARK20; Parkin; PI(4,5)P2; synaptic vesicle endocytosis; synaptojanin 1

Indexed keywords

AUXILIN; CLATHRIN; PARKIN; SYNAPTOJANIN; SYNAPTOJANIN 1; UNCLASSIFIED DRUG; DOPAMINE; PHOSPHATASE; PHOSPHOINOSITIDE 5-PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; DORSAL STRIATUM; ENDOCYTOSIS; FEMALE; HOMOZYGOUS MUTATION; MALE; MUTATION; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; PARKINSONISM; PROTEIN DOMAIN; SYNAPSE; ANIMAL; AXON; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; AXONS; CLATHRIN; DOPAMINE; ENDOCYTOSIS; HUMANS; MICE, TRANSGENIC; MUTATION; PARKINSON DISEASE; PARKINSONIAN DISORDERS; PHOSPHORIC MONOESTER HYDROLASES; SYNAPSES;

EID: 85013648443     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2017.01.019     Document Type: Article

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