Oxidative stress-mediated NFeκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Song, Chunjuan ^a,d   Mitter, Sayak K ^b   Qi, Xiaoping ^b   Beli, Eleni ^b   Rao, Haripriya V ^a   Ding, Jindong ^c   Ip, Colin S ^b   Gu, Hongmei ^b   Akin, Debra ^a   Dunn, William A ^a   Rickman, Catherine Bowes ^c   Lewin, Alfred S ^a   Grant, Maria B ^b   Boulton, Michael E ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b INDIANA UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d APPLIED GENETIC TECHNOLOGIES CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; AUTOPHAGY RELATED PROTEIN; AUTOPHAGY RELATED PROTEIN 10; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTACYSTIN; MESSENGER RNA; PROTEASOME; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; P62 PROTEIN, HUMAN; RNA BINDING PROTEIN; SEQUESTOSOME 1; SQSTM1 PROTEIN, HUMAN; SUPEROXIDE;

AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL FRACTIONATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEPLETION; DOWN REGULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETINA; RETINAL PIGMENT EPITHELIUM; RNA ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; MACULAR DEGENERATION; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; MACULAR DEGENERATION; MICE; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; RNA-BINDING PROTEINS; SEQUESTOSOME-1 PROTEIN; SUPEROXIDES; UP-REGULATION;

EID: 85013647228     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0171940     Document Type: Article

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