PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Molecular Cell

Volumn 65, Issue 5, 2017, Pages 900-916.e7

  Clarke, Thomas L ^a   Sanchez Bailon, Maria Pilar ^a   Chiang, Kelly ^a   Reynolds, John J ^a   Herrero Ruiz, Joaquin ^a   Bandeiras, Tiago M ^b   Matias, Pedro M ^b,c   Maslen, Sarah L ^d   Skehel, J Mark ^d   Stewart, Grant S ^a   Davies, Clare C ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^c INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

52BP1; arginine methylation; DNA repair; homologous recombination; PRMT5; RUVBL1; TIP60

Indexed keywords

PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN RUVBL1; PROTEIN TIP60; UNCLASSIFIED DRUG; ARGININE; ATM PROTEIN; ATM PROTEIN, HUMAN; CARRIER PROTEIN; DNA HELICASE; HISTONE; HISTONE ACETYLTRANSFERASE; KAT5 PROTEIN, HUMAN; PRMT5 PROTEIN, HUMAN; PRMT5 PROTEIN, MOUSE; RUVBL1 PROTEIN, HUMAN; TP53BP1 PROTEIN, HUMAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE RESPONSE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; GENOMIC INSTABILITY; HISTONE ACETYLATION; HOMOLOGOUS RECOMBINATION; METHYLATION; NONHUMAN; PROTEIN LOCALIZATION; ACETYLATION; ANIMAL; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; METABOLISM; MOUSE; PROTEIN PROCESSING; RECOMBINATION REPAIR; RNA INTERFERENCE; TIME FACTOR; TRANSGENIC MOUSE;

ACETYLATION; ANIMALS; ARGININE; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CARRIER PROTEINS; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; GENOMIC INSTABILITY; HEK293 CELLS; HELA CELLS; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; METHYLATION; MICE; MICE, TRANSGENIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-ARGININE N-METHYLTRANSFERASES; RECOMBINATIONAL DNA REPAIR; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1;

EID: 85013633978     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.01.019     Document Type: Article

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