The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

Molecular Cell

Volumn 62, Issue 3, 2016, Pages 409-421

  Jacquet, Karine ^a,b   Fradet Turcotte, Amélie ^a,b,c   Avvakumov, Nikita ^a,b   Lambert, Jean Philippe ^c   Roques, Céline ^a,b   Pandita, Raj K ^d   Paquet, Eric ^a,b   Herst, Pauline ^a,b   Gingras, Anne Claude ^c,e   Pandita, Tej K ^d   Legube, Gaëlle ^f   Doyon, Yannick ^b   Durocher, Daniel ^c,e   Côté, Jacques ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f Université Paul Sabatier   (France)

Author keywords

53BP1; Acetylation; H2AK15; H4K20; Histone methylation; Homologous recombination; MBTD1; NuA4; TIP60; Ubiquitylation

Indexed keywords

ACYLTRANSFERASE; BINDING PROTEIN; DOUBLE STRANDED DNA; HISTONE H2A; HISTONE H2AK; PROTEIN; PROTEIN 53BP1; PROTEIN MBTD1; PROTEIN TIP60; UNCLASSIFIED DRUG; EPC1 PROTEIN, HUMAN; HISTONE; HISTONE ACETYLTRANSFERASE; KAT5 PROTEIN, HUMAN; MBTD1 PROTEIN, HUMAN; NONHISTONE PROTEIN; PROTEIN BINDING; REPRESSOR PROTEIN; TP53BP1 PROTEIN, HUMAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

ARTICLE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; HISTONE ACETYLATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; UBIQUITINATION; ACETYLATION; BINDING COMPETITION; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CRISPR CAS SYSTEM; DNA REPAIR; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; K-562 CELL LINE; METABOLISM; PROTEIN PROCESSING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR;

ACETYLATION; BINDING SITES; BINDING, COMPETITIVE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMAL PROTEINS, NON-HISTONE; CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; K562 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; UBIQUITINATION;

EID: 84966534281     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.03.031     Document Type: Article

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