Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression

Stem Cell Research

Volumn 20, Issue , 2017, Pages 14-20

  Hu, Liang ^a,b,c   Du, Lili ^d,e   Zhao, Yan ^b   Li, Wen ^a,c   Ouyang, Qi ^a,b,c   Zhou, Di ^a,b,c   Lu, Guangxiu ^a,b,c   Lin, Ge ^a,b,c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b National Center of Human Stem Cell Research and Engineering   (China)

^c BEIJING HOSPITAL   (China)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

^e Key Laboratory for Major Obstetric Diseases of Guangdong Province   (China)

Author keywords

CD41; Glanzmann thrombasthenia; Induced pluripotent stem cells; Platelet

Indexed keywords

ADENOSINE DIPHOSPHATE; BETA3 INTEGRIN; DUAL SPECIFICITY PHOSPHATASE 2; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB ALPHA; ALPHA2 INTEGRIN; DUSP2 PROTEIN, HUMAN; GLYCOPROTEIN IIB; ITGA2B PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CHILD; ENZYME ACTIVATION; GENE; GENE OVEREXPRESSION; GLANZMANN DISEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; ITGA2B GENE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SKIN FIBROBLAST; THROMBOCYTE AGGREGATION; ANIMAL; CELL LINE; CYTOLOGY; DNA MUTATIONAL ANALYSIS; FIBROBLAST; GENETIC POLYMORPHISM; GENETICS; KARYOTYPE; METABOLISM; MOUSE; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; TERATOMA; THROMBOCYTE; TRANSPLANTATION;

ANIMALS; BASE SEQUENCE; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL LINE; CELLULAR REPROGRAMMING; DNA MUTATIONAL ANALYSIS; DUAL SPECIFICITY PHOSPHATASE 2; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTEGRIN ALPHA2; KARYOTYPE; MICE; MICE, NUDE; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEIN IIB; POLYMORPHISM, GENETIC; TERATOMA; THROMBASTHENIA; TRANSCRIPTION FACTORS;

EID: 85013288109     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2017.02.003     Document Type: Article

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