Functional comparison of induced pluripotent stem cell-and blood-derived gpiibiiia deficient platelets

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Orban, Mathias ^a   Goedel, Alexander ^b   Haas, Jessica ^b   Sandrock Lang, Kirstin ^c   Gärtner, Florian ^a   Jung, Christian Billy ^b   Zieger, Barbara ^c   Parrotta, Elvira ^b,d   Kurnik, Karin ^a   Sinnecker, Daniel ^b   Wanner, Gerhard ^e   Laugwitz, Karl Ludwig ^b,f   Massberg, Steffen ^a,f   Moretti, Alessandra ^b,f  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e UNIVERSITY OF MUNICH   (Germany)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; INTEGRIN RECEPTOR; ALPHA2 INTEGRIN; ITGA2B PROTEIN, HUMAN;

ADULT; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GLANZMANN DISEASE; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE; ADOLESCENT; BIOLOGICAL MODEL; CELL CULTURE; CYTOLOGY; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY;

ADOLESCENT; BLOOD PLATELETS; CELL ADHESION; CELLS, CULTURED; FEMALE; FIBRINOGEN; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTEGRIN ALPHA2; MODELS, BIOLOGICAL; THROMBASTHENIA;

EID: 84956587222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115978     Document Type: Article

References (45)

1. Nurden P, Nurden AT (2008) Congenital disorders associated with platelet dysfunctions. Thromb Haemost 99: 253-63. doi: 10.1160/TH07-09-0568 PMID: 18278172
2. Nachman RL, Leung LL (1982) Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen. J Clin Invest 69: 263-9. doi: 10.1172/JCI110448 PMID: 6460044
3. Engelmann B, Massberg S (2013) Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol 13: 34-45. doi: 10.1038/nri3345 PMID: 23222502
4. Massberg S, Schürzinger K, Lorenz M, Konrad I, Schulz C, et al. (2005) Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation 112: 1180-8. doi: 10.1161/CIRCULATIONAHA.105.539221 PMID: 16103235
5. Schattner M, Lefebvre P, Mingolelli SS, Goolsby CL, Rademaker A, et al. (1996) Thrombopoietinstimulated ex vivo expansion of human bone marrow megakaryocytes. Stem Cells 14: 207-14. doi: 10. 1002/stem.140207 PMID: 8991540
6. Gehling UM, Ryder JW, Hogan CJ, Hami L, McNiece I, et al. (1997) Ex vivo expansion of megakaryocyte progenitors: effect of various growth factor combinations on CD34+ progenitor cells from bone marrow and G-CSF-mobilized peripheral blood. Exp Hematol 25: 1125-39. PMID: 9328449
7. Schipper LF, Brand A, Reniers NC, Melief CJ, Willemze R, et al. (1998) Effects of thrombopoietin on the proliferation and differentiation of primitive and mature haemopoietic progenitor cells in cord blood. Br J Haematol 101: 425-35. doi: 10.1046/j.1365-2141.1998.00737.x PMID: 9633882
8. Wilcox DA, Olsen JC, Ishizawa L, Bray PF, French DL, et al. (2000) Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. Blood 95: 3645-51. PMID: 10845892
9. Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, et al. (2010) Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468: 521-6. doi: 10.1038/nature09591 PMID: 21057492
10. Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, et al. (2012) Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood 120: 3812-21. doi: 10.1182/blood-2012-02-413617 PMID: 22855609
11. Harris DM, Hazan-Haley I, Coombes K, Bueso-Ramos C, Liu J, et al. (2011) Transformation of human mesenchymal cells and skin fibroblasts into hematopoietic cells.
12. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-72. doi: 10.1016/j.cell.2007.11.019 PMID: 18035408
13. Sinnecker D, Goedel A, Laugwitz KL, Moretti A (2013) Induced pluripotent stem cell-derived cardiomyocytes: a versatile tool for arrhythmia research. Circ Res 112: 961-8. doi: 10.1161/ CIRCRESAHA.112.268623 PMID: 23569105
14. Raya A, Rodríguez-Pizà I, Guenechea G, Vassena R, Navarro S, et al. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460: 53-9. doi: 10.1038/nature08129 PMID: 19483674
15. Ye L, Chang JC, Lin C, Sun X, Yu J, et al. (2009) Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A 106: 9826-30. doi: 10.1073/pnas.0904689106 PMID: 19482945
16. Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, et al. (2012) Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood 119: 6234-42. doi:10. 1182/blood-2011-07-367441 PMID: 22592606
17. Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, et al. (2013) Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest 123: 3802-14. doi: 10.1172/JCI64721 PMID: 23908116
18. Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, et al. (2013) Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Cell Stem Cell 12: 727-36. doi: 10.1016/j.stem.2013.04.002 PMID: 23602541
19. Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, et al. (2014) Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Reports 2: 205-18. doi: 10.1016/j.stemcr.2013.12.007 PMID: 24527394
20. Nakamura S, Takayama N, Hirata S, Seo H, Endo H, et al. (2014) Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell 14: 535-48. doi: 10.1016/j.stem.2014.01.011 PMID: 24529595
21. Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, et al. (2014) High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood 123: 753-7. doi: 10.1182/blood-2013-10-530725 PMID: 24335497
22. Robinton DA, Daley GQ (2012) The promise of induced pluripotent stem cells in research and therapy. Nature 481: 295-305. doi: 10.1038/nature10761 PMID: 22258608
23. Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, et al. (2013) Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell 12: 252-64. doi: 10.1016/j.stem.2012.12.002 PMID: 23395447
24. Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, et al. (2013) Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J Neurosci 33: 574-86. doi:10. 1523/JNEUROSCI.0906-12.2013 PMID: 23303937
25. Seki T, Yuasa S, Oda M, Egashira T, Yae K, et al. (2010) Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell 7: 11-14. doi: 10.1016/j.stem. 2010.06.003 PMID: 20621043
26. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, et al. (2010) Patient-specific induced pluripotent stemcell models for long-QT syndrome. N Engl J Med 363: 1397-409. doi: 10.1056/NEJMoa0908679 PMID: 20660394
27. Müller FJ, Schuldt BM, Williams R, Mason D, Altun G, et al. (2011) A bioinformatic assay for pluripotency in human cells. Nat Methods 8:315-7. doi: 10.1038/nmeth.1580 PMID: 21378979
28. Vannier C, Behnisch W, Bartsch I, Sandrock K, Ertle F, et al. (2010) Novel homozygous mutation (c.175delG) in platelet glycoprotein ITGA2B gene as cause of Glanzmann's thrombasthenia type I. Klin Padiatr 222: 150-153. doi: 10.1055/s-0030-1249064 PMID: 20514618
29. Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, et al. (2010) Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med 207: 2817-30. doi: 10.1084/jem.20100844 PMID: 21098095
30. Jogler C, Wanner G, Kolinko S, Niebler M, Amann R, et al. (2011) Conservation of proteobacterial magnetosome genes and structures in an uncultivated member of the deep-branching Nitrospira phylum. Proc Natl Acad Sci U S A 108: 1134-9. doi: 10.1073/pnas.1012694108 PMID: 21191098
31. Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, et al. (2008) Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood 119: 6234-42
32. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101: 508-16. doi: 10.1182/blood-2002-06-1699 PMID: 12393529
33. Hartley PS, Savill J, Brown SB (2006) The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets. Thromb Haemost 95: 100-6. PMID: 16543968
34. Hartley PS (2005) Factors affecting the viability of human platelets. Ph.D. Thesis, University of Edinburgh. Available: http://www.academia.edu/247183/Factors-Affecting-the-Viability-of-Human-Platelets. Accessed 2014 Oct. 27.
35. Yuan Y, Kulkarni S, Ulsemer P, Cranmer SL, Yap CL, et al. (1999) The von Willebrand factorglycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells. J Biol Chem 51: 36241-51. doi: 10.1074/jbc.274. 51.36241 PMID: 10593912
36. Wu SM, Hochedlinger K (2011) Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol 13: 497-505. doi: 10.1038/ncb0511-497 PMID: 21540845
37. Ma D, Wei H, Lu J, Ho S, Zhang G, et al. (2013) Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 34: 1122-33. doi: 10.1093/eurheartj/ehs226 PMID: 22798562
38. Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, et al. (2011) Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478: 391-394 doi: 10.1038/ nature10424 PMID: 21993621
39. Nurden AT, Fiore M, Nurden P, Pillois X (2011) Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood 118: 5996-6005 doi: 10.1182/blood-2011-07-365635 PMID: 21917754
40. Nurden AT, Pillois X, Wilcox DA (2013) Glanzmann thrombasthenia: state of the art and future directions. Semin Thromb Hemost 39: 642-55 doi: 10.1055/s-0033-1353393 PMID: 23929305
41. Armstrong PC, Peter K (2012) GPIIb/IIIa inhibitors: from bench to bedside and back to bench again. Thromb Haemost 107: 808-14. doi: 10.1160/TH11-10-0727 PMID: 22370973
42. Blondel S, Jaskowiak AL, Egesipe AL, Le Corf A, Navarro C, et al. (2014) Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinsongilford progeria syndrome. Stem Cells Transl Med 4:510-9 doi: 10.5966/sctm.2013-0168 PMID: 24598781
43. Streckfuss-Bömeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, et al. (2013) Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts. Eur Heart J 34: 2618-29. doi: 10.1093/eurheartj/ehs203 PMID: 22798560
44. Lin B, Kim J, Li Y, Pan H, Carvajal-Vergara X, et al. (2012) High-purity enrichment of functional cardiovascular cells from human iPS cells. Cardiovasc Res 95: 327-35. doi: 10.1093/cvr/cvs185 PMID: 22673369
45. Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, et al. (2013) Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes. Exp Hematol 41: 742-8. doi: 10.1016/j.exphem.2013.04.007 PMID: 23618622