Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity

Cell Reports

Volumn 18, Issue 7, 2017, Pages 1587-1597

  Steculorum, Sophie Marie ^a,b,c   Timper, Katharina ^a,b,c   Engström Ruud, Linda ^a,b,c   Evers, Nadine ^a,b,c   Paeger, Lars ^c,d   Bremser, Stephan ^c,d   Kloppenburg, Peter ^c,d   Brüning, Jens Claus ^a,b,c,e  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

AgRP neurons; arcuate nucleus; diabetes; food intake; hypothalamus; insulin resistance; insulin sensitivity; obesity; P2Y6

Indexed keywords

AGOUTI RELATED PROTEIN; INSULIN; PURINERGIC P2Y6 RECEPTOR; URIDINE DIPHOSPHATE; AGRP PROTEIN, MOUSE; PURINERGIC P2 RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; BRAIN SLICE; CONTROLLED STUDY; FAT MASS; FEMALE; FOOD INTAKE; HYPERPHAGIA; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MALE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; OBESITY; PATCH CLAMP TECHNIQUE; PROTEIN FUNCTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; DIET; DISEASE MODEL; DRUG EFFECTS; EATING; FEEDING BEHAVIOR; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; PROCEDURES;

AGOUTI-RELATED PROTEIN; ANIMALS; DIET; DISEASE MODELS, ANIMAL; EATING; FEEDING BEHAVIOR; HYPERPHAGIA; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NEURONS; OBESITY; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; URIDINE DIPHOSPHATE;

EID: 85013223225     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.01.047     Document Type: Article

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