HPV-16 E6 promotes cell growth of esophageal cancer via downregulation of miR-125b and activation of Wnt/β-catenin signaling pathway

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 10, 2015, Pages 13687-13694

  Zang, Bao ^a,b   Huang, Guojin ^a,c   Wang, Xiaowei ^b   Zheng, Shiying ^a  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

Esophageal cancer; HPV 16 E6; MiR 125b; Wnt catenin

Indexed keywords

BETA CATENIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; GLYCOGEN SYNTHASE KINASE 3BETA; MICRORNA; MIRN125 MICRORNA, HUMAN; ONCOPROTEIN; REPRESSOR PROTEIN;

CELL PROLIFERATION; CELL TRANSFORMATION; DOWN REGULATION; ESOPHAGUS TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; MALE; METABOLISM; PAPILLOMAVIRUS INFECTION; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; UPREGULATION; VIROLOGY; WNT SIGNALING PATHWAY;

BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMAN PAPILLOMAVIRUS 16; HUMANS; MALE; MICRORNAS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS INFECTIONS; REPRESSOR PROTEINS; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 85013141969     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
2. Hongo M, Nagasaki Y and Shoji T. Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 2009; 24: 729-735.
3. Zeng H, Zheng R, Guo Y, Zhang S, Zou X, Wang N, Zhang L, Tang J, Chen J, Wei K, Huang S, Wang J, Yu L, Zhao D, Song G, Chen J, Shen Y, Yang X, Gu X, Jin F, Li Q, Li Y, Ge H, Zhu F, Dong J, Guo G, Wu M, Du L, Sun X, He Y, Coleman MP, Baade P, Chen W and Yu XQ. Cancer survival in China, 2003-2005: a population-based study. Int J Cancer 2015; 136: 1921-1930.
4. Trottier H and Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006; 24 Suppl 1: S1-15.
5. Hardefeldt HA, Cox MR and Eslick GD. Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infect 2014; 142: 1119-1137.
6. Li M, He XY, Zhang ZM, Li S, Ren LH, Cao RS, Feng YD, Ji YL, Zhao Y and Shi RH. MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis. World J Gastroenterol 2015; 21: 3245-3255.
7. Yong F, Xudong N and Lijie T. Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. Ann Epidemiol 2013; 23: 726-734.
8. Esquela-Kerscher A and Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-269.
9. Jiang Z, Song Q, Yang S, Zeng R, Li X, Jiang C, Ding W, Zhang J and Zheng Y. Serum microRNA-218 is a potential biomarker for esophageal cancer. Cancer Biomark 2015; 15: 381-9.
10. Qi Y, Li X and Zhao S. miR-29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP-2. Neoplasma 2015; 62: 384-390.
11. Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM and Fusco A. Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene 2007; 26: 7590-7595.
12. Zhang Y, Yan LX, Wu QN, Du ZM, Chen J, Liao DZ, Huang MY, Hou JH, Wu QL, Zeng MS, Huang WL, Zeng YX and Shao JY. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res 2011; 71: 3552-3562.
13. Zhao A, Zeng Q, Xie X, Zhou J, Yue W, Li Y and Pei X. MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. J Genet Genomics 2012; 39: 29-35.
14. Peng SC, Liao CT, Peng CH, Cheng AJ, Chen SJ, Huang CG, Hsieh WP and Yen TC. MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma. PLoS One 2014; 9: e102403.
15. Barker N and Clevers H. Catenins, Wnt signaling and cancer. Bioessays 2000; 22: 961-965.
16. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J and Lowy AM. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 2002; 62: 3503-3506.
17. Polakis P. Wnt signaling in cancer. Cold Spring Harb Perspect Biol 2012; 4.
18. Kadowaki T, Shiozaki H, Inoue M, Tamura S, Oka H, Doki Y, Iihara K, Matsui S, Iwazawa T, Nagafuchi A, et al. E-cadherin and alpha-catenin expression in human esophageal cancer. Cancer Res 1994; 54: 291-296.
19. Mizushima T, Nakagawa H, Kamberov YG, Wilder EL, Klein PS and Rustgi AK. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res 2002; 62: 277-282.
20. Nakanishi Y, Ochiai A, Akimoto S, Kato H, Watanabe H, Tachimori Y, Yamamoto S and Hirohashi S. Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions. Oncology 1997; 54: 158-165.
21. Jiang M and Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002; 21: 6041-6048.
22. Yoshinouchi M, Yamada T, Kizaki M, Fen J, Koseki T, Ikeda Y, Nishihara T and Yamato K. In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA. Mol Ther 2003; 8: 762-768.
23. Cheng YW, Wu MF, Wang J, Yeh KT, Goan YG, Chiou HL, Chen CY and Lee H. Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation. Cancer Res 2007; 67: 10686-10693.
24. Li X, Gao C, Yang Y, Zhou F, Li M, Jin Q and Gao L. Systematic review with meta-analysis: the association between human papillomavirus infection and oesophageal cancer. Aliment Pharmacol Ther 2014; 39: 270-281.
25. Nuovo GJ, Wu X, Volinia S, Yan F, di Leva G, Chin N, Nicol AF, Jiang J, Otterson G, Schmittgen TD and Croce C. Strong inverse correlation between microRNA-125b and human papillomavirus DNA in productive infection. Diagn Mol Pathol 2010; 19: 135-143.
26. Katoh M and Katoh M. WNT signaling pathway and stem cell signaling network. Clin Cancer Res 2007; 13: 4042-4045.
27. van Amerongen R, Bowman AN and Nusse R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 2012; 11: 387-400.
28. Cadigan KM and Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997; 11: 3286-3305.
29. Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Hill AA, Akhter MP, Johnson ML, Recker RR, Komm BS and Bex FJ. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006; 281: 31720-31728.
30. Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA and Jaenisch R. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 2008; 3: 132-135.
31. Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG and Baylin SB. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004; 36: 417-422.
32. Carmon KS and Loose DS. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol Cancer Res 2008; 6: 1017-1028.
33. Warrier S, Balu SK, Kumar AP, Millward M and Dharmarajan A. Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells. Oncol Res 2013; 21: 93-102.
34. Ge C, Wu S, Wang W, Liu Z, Zhang J, Wang Z, Li R, Zhang Z, Li Z, Dong S, Wang Y, Xue Y, Yang J, Tan Q, Wang Z and Song X. miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/beta-catenin signalling pathway. Oncotarget 2015; 6: 10964-77.