Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia

Critical Care

Volumn 21, Issue 1, 2017, Pages

  Zhou, Xiang ^a   Liu, Dawei ^a   Su, Longxiang ^a   Yao, Bo ^b   Long, Yun ^a   Wang, Xiaoting ^a   Chai, Wenzhao ^a   Cui, Na ^a   Wang, Hao ^a   Rui, Xi ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Hemodynamic therapy; Lactate kinetics; ScvO2; Sepsis; Septic shock

Indexed keywords

ANTIBIOTIC AGENT; BILIRUBIN; DOBUTAMINE; GLUCOCORTICOID; INOTROPIC AGENT; LACTIC ACID; NORADRENALIN; VASODILATOR AGENT; OXYGEN;

ADULT; ADVERSE OUTCOME; ARTICLE; ARTIFICIAL VENTILATION; BLOOD OXYGEN TENSION; CLINICAL OUTCOME; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART RATE; HEMODYNAMIC THERAPY; HEMODYNAMICS; HUMAN; HUMAN CELL; HYPERLACTATEMIA; INTENSIVE CARE UNIT; KINETICS; LENGTH OF STAY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SEPSIS; SEPTIC SHOCK; SURVIVAL TIME; TREATMENT RESPONSE; VENOUS BLOOD; AGED; BLOOD; CHI SQUARE DISTRIBUTION; CHINA; COMPLICATION; MIDDLE AGED; NONPARAMETRIC TEST; ORGANIZATION AND MANAGEMENT; PHYSIOLOGY; PRACTICE GUIDELINE; PROCEDURES; PROSPECTIVE STUDY; RESUSCITATION; STANDARDS; TREATMENT OUTCOME;

ADULT; AGED; CHI-SQUARE DISTRIBUTION; CHINA; FEMALE; GUIDELINES AS TOPIC; HEART RATE; HEMODYNAMICS; HUMANS; HYPERLACTATEMIA; INTENSIVE CARE UNITS; KINETICS; LACTIC ACID; MALE; MIDDLE AGED; OXYGEN; PROSPECTIVE STUDIES; RESUSCITATION; SEPSIS; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 85013011615     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-017-1617-1     Document Type: Article

References (27)

1. Jawad I, Luksic I, Rafnsson SB. Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. J Glob Health. 2012;2(1):010404.
2. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, Vincent JL, Townsend S, Lemeshow S, Dellinger RP. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis. 2012;12(12):919-24.
3. Cuthbertson BH, Elders A, Hall S, Taylor J, MacLennan G, Mackirdy F, Mackenzie SJ, Scottish Critical Care Trials Group, Scottish Intensive Care Society Audit Group. Mortality and quality of life in the five years after severe sepsis. Crit Care. 2013;17(2):R70.
4. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-77.
5. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858-73.
6. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36(1):296-327.
7. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228.
8. Pro CI, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370(18):1683-93.
9. Investigators A, Group ACT, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371(16):1496-506.
10. Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015;372(14):1301-11.
11. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S, Emergency Medicine Shock Research Network (EMShockNet) Investigators. Multicenter study of early lactate kinetics as a determinant of survival in patients with presumed sepsis. Shock. 2009;32(1):35-9.
12. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, Tomlanovich MC. Early lactate kinetics is associated with improved outcome in severe sepsis and septic shock. Crit Care Med. 2004;32(8):1637-42.
13. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Heffner AC, Kline JA, Jones AE, Emergency Medicine Shock Research Network (EMSHOCKNET). Prognostic value and agreement of achieving lactate kinetics or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med. 2012;19(3):252-8.
14. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate kinetics vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010;303(8):739-46.
15. Walker CA, Griffith DM, Gray AJ, Datta D, Hay AW. Early lactate kinetics in septic patients with elevated lactate levels admitted from the emergency department to intensive care: time to aim higher? J Crit Care. 2013;28(5):832-7.
16. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644-55.
17. Rhodes A, Phillips G, Beale R, Cecconi M, Chiche JD, De Backer D, Divatia J, Du B, Evans L, Ferrer R, et al. The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Med. 2015;41(9):1620-8.
18. Coz YA. Protocol-based care for early septic shock. N Engl J Med. 2014;371(4):384-5.
19. Manaktala S, Claypool SR. Early, goal-directed resuscitation for septic shock. N Engl J Med. 2015;373(6):577.
20. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI, Emergency Medicine Shock Research Network Investigators. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010;55(1):40-6. e41.
21. Textoris J, Fouche L, Wiramus S, Antonini F, Tho S, Martin C, Leone M. High central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality. Crit Care. 2011;15(4):R176.
22. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest. 1991;99(4):956-62.
23. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 2009;37(5):1670-7.
24. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J, Lactate Study Group. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med. 2010;182(6):752-61.
25. Tian HH, Han SS, Lv CJ, Wang T, Li Z, Hao D, Shang QM, Wang XZ. The effect of early goal lactate kinetics rate on the outcome of septic shock patients with severe pneumonia. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012;24(1):42-5.
26. Vincent JL. Serial blood lactate levels reflect both lactate production and clearance. Crit Care Med. 2015;43(6):e209.
27. Vincent JL. Lactic acidosis. N Engl J Med. 2015;372(11):1077-8.