Early lactate clearance in septic patients with elevated lactate levels admitted from the emergency department to intensive care: Time to aim higher?

Journal of Critical Care

Volumn 28, Issue 5, 2013, Pages 832-837

  Walker, Craig A ^a   Griffith, David M ^a   Gray, Alasdair J ^a   Datta, Deepankar ^a   Hay, Alasdair W ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Lactate clearance; Mortality; Predict; Sepsis

Indexed keywords

LACTIC ACID;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLEARANCE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; EMERGENCY PATIENT; EMERGENCY WARD; FEMALE; HUMAN; INTENSIVE CARE; LACTATE BLOOD LEVEL; LACTATE CLEARANCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SEPTIC SHOCK; TIME OF DEATH;

LACTATE CLEARANCE; MORTALITY; PREDICT; SEPSIS;

ADULT; AGED; AGED, 80 AND OVER; APACHE; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LACTIC ACID; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SCOTLAND; SEPSIS; SHOCK, SEPTIC; TIME FACTORS;

EID: 84883557936     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2013.02.004     Document Type: Article

References (18)

1. Vincent J.L., Sakr Y., Sprung C.L., Ranieri V.M., Reinhart K., et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006, 34(2):344-353.
2. Martin G.S., Mannino D.M., Eaton S., Moss M. The epidemiology of sepsis in the united states from 1979 through 2000. N Engl J Med 2003, 348(16):1546-1554.
3. Bakker J., Coffernils M., Leon M., Gris P., Vincent J.L. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991, 99(4):956-962.
4. Mikkelsen M.E., Miltiades A.N., Gaieski D.F., Goyal M., Fuchs B.D., Shah C.V., et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37(5):1670-1677.
5. Arnold R.C., Shapiro N.I., Jones A.E., Schorr C., Pope J., Casner E., et al. Emergency Medicine Shock Research Network (EMShockNet) Investigators. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009, 32(1):35-39.
6. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345(19):1368-1377.
7. Dellinger R.P., Levy M.M., Rhodes A., Annane D., Gerlach H., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41(2):580-637.
8. Jones A.E., Shapiro N.I., Trzeciak S., Arnold R.C., Claremont H.A., Kline J.A. Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs. central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010, 303(8):739-746.
9. Nguyen H.B., Rivers E.P., Knoblich B.P., Jacobsen G., Muzzin A., Ressler J.A., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32(8):1637-1642.
10. Audit of Critical Care in Scotland 2011, Reporting on 2010 Scottish Intensive Care Society Audit Group (SICSAG). http://www.sicsag.scot.nhs.uk/Publications/SICSAG-report_2011-webversion.pdf.
11. Millar B. Ward Watcher (Version 11.81) [Computer Program] 2010, Critical Care Audit Group Ltd, Scotland.
12. Youden W.J. An index for rating diagnostic tests. Cancer 1950, 3:32-35.
13. Development Core Team R: A language and environment for statistical computing 2010, R Foundation for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0, URL. http://www.R-project.org/.
14. Bakker J., et al. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 1996, 171(2):221-226.
15. Yang C.S., Qiu H.B., Huang Y.Z., Xie J.F., Mo M., Liu S.Q., et al. Prospective research on the prognosis of septic shock based on the change of lactate concentration in arterial blood. Chung Hua Wai Ko Tsa Chih 2009, 47(9):685-688.
16. Nguyen H.B., Kuan W.S., Batech M., Shrikhande P., Mahadevan M., Li C.H., et al. Asia Network to Regulate Sepsis Care (ATLAS) Investigators. Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as bundle item: a multi-national evaluation. Crit Care 2011, 15:R229.
17. Jansen T.C., van Bommel J., Schoonderbeek F.J., Sleeswijk Visser S.J., van der Klooster J.M., Lima A.P., et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010 Sep 15, 182(6):752-761.
18. Tian H., Han S., Lv C., Wang T., Li Z., Hao D., et al. The effect of early goal lactate clearance rate on the outcome of septic shock patients with severe pneumonia. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2012, 24(1):42-45.