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4 Moore, E.E., Moore, H.B., Gonzalez, E., et al. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion (Paris) 56:Suppl 2 (2016), S110–S114.
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5
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Acute traumatic coagulopathy
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6
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6 MacLeod, J.B., Lynn, M., McKenney, M.G., et al. Early coagulopathy predicts mortality in trauma. J Trauma 55 (2003), 39–44.
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7
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7 Schochl, H., Frietsch, T., Pavelka, M., Jambor, C., Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 67 (2009), 125–131.
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8
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discussion 443–444
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8 Kashuk, J.L., Moore, E.E., Sawyer, M., et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg 252 (2010), 434–442 discussion 443–444.
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9
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Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
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discussion 370
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9 Cotton, B.A., Harvin, J.A., Kostousouv, V., et al. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg 73 (2012), 365–370 discussion 370.
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10
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Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma
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10 Ives, C., Inaba, K., Branco, B.C., et al. Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma. J Am Coll Surg 215 (2012), 496–502.
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11
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Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients
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11 Cardenas, J.C., Matijevic, N., Baer, L.A., et al. Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients. Shock 41 (2014), 514–521.
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12
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discussion 817
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12 Moore, H.B., Moore, E.E., Gonzalez, E., et al. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 77 (2014), 811–817 discussion 817.
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Moore, H.B.1
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13
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Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients
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discussion 23–25
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13 Chapman, M.P., Moore, E.E., Moore, H.B., et al. Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg 80 (2016), 16–23 discussion 23–25.
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14
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Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock
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14 Moore, H.B., Moore, E.E., Lawson, P.J., et al. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery 158 (2015), 386–392.
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15
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Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients
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15 Moore, H.B., Moore, E.E., Liras, I.N., et al. Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients. J Am Coll Surg 222 (2016), 347–355.
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16
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Hypercoagulability is most prevalent early after injury and in female patients
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discussion 480–481
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16 Schreiber, M.A., Differding, J., Thorborg, P., et al. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma 58 (2005), 475–480 discussion 480–481.
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17 Van Haren, R.M., Thorson, C.M., Valle, E.J., et al. Hypercoagulability after burn injury. J Trauma Acute Care Surg 75 (2013), 37–43.
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18
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Hypercoagulability and other risk factors in trauma intensive care unit patients with venous thromboembolism
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18 Van Haren, R.M., Valle, E.J., Thorson, C.M., et al. Hypercoagulability and other risk factors in trauma intensive care unit patients with venous thromboembolism. J Trauma Acute Care Surg 76 (2014), 443–449.
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19
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Reaction pattern to three stresses–electroplexy, surgery, and myocardial infarction–of fibrinolysis and plasma fibrinogen
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19 Chakrabarti, R., Hocking, E.D., Fearnley, G.R., Reaction pattern to three stresses–electroplexy, surgery, and myocardial infarction–of fibrinolysis and plasma fibrinogen. J Clin Pathol 22 (1969), 659–662.
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20
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20 Greenfield, L.J., Proctor, M.C., Rodriguez, J.L., et al. Posttrauma thromboembolism prophylaxis. J Trauma 42 (1997), 100–103.
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21
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84948976799
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Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation
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discussion 903–904
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21 Moore, H.B., Moore, E.E., Morton, A.P., et al. Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation. J Trauma Acute Care Surg 79 (2015), 897–903 discussion 903–904.
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22
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22 Shakur, H., Roberts, I., Bautista, R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376 (2010), 23–32.
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23
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Do all trauma patients benefit from tranexamic acid?
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23 Valle, E.J., Allen, C.J., Van Haren, R.M., et al. Do all trauma patients benefit from tranexamic acid?. J Trauma Acute Care Surg 76 (2014), 1373–1378.
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24
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The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis
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24 Harvin, J.A., Peirce, C.A., Mims, M.M., et al. The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis. J Trauma Acute Care Surg 78 (2015), 905–909 discussion 909–911.
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Differences between blunt and penetrating trauma after resuscitation with hydroxyethyl starch
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25 Allen, C.J., Valle, E.J., Jouria, J.M., et al. Differences between blunt and penetrating trauma after resuscitation with hydroxyethyl starch. J Trauma Acute Care Surg 77 (2014), 859–864.
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26
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Admission hyperglycemia is associated with different outcomes after blunt versus penetrating trauma
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26 Meizoso, J.P., Ray, J.J., Karcutskie, C.A., et al. Admission hyperglycemia is associated with different outcomes after blunt versus penetrating trauma. J Surg Res 206 (2016), 83–89.
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27 Holcomb, J.B., Fluid resuscitation in modern combat casualty care: lessons learned from Somalia. J Trauma 54:5 Suppl (2003), S46–S51.
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28 McSwain, N.E., Champion, H.R., Fabian, T.C., et al. State of the art of fluid resuscitation 2010: prehospital and immediate transition to the hospital. J Trauma 70:5 Suppl (2011), S2–S10.
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29
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Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
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29 James, M.F., Michell, W.L., Joubert, I.A., et al. Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma). Br J Anaesth 107 (2011), 693–702.
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30 Karcutskie, C.A., Meizoso, J.P., Ray, J.J., et al. Association of mechanism of injury with risk for venous thromboembolism after trauma. JAMA Surg 152 (2017), 35–40.
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31
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Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy
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31 Chapman, M.P., Moore, E.E., Ramos, C.R., et al. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg 75 (2013), 961–967 discussion 967.
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