Non-fermentative Gram-negative rods bacteremia in children with cancer: a 14-year single-center experience

Infection

Volumn 45, Issue 3, 2017, Pages 327-334

  Averbuch, D ^a   Avaky, C ^a   Harit, M ^a   Stepensky, P ^a   Fried, I ^a   Ben Ami, T ^a   Temper, V ^a   Peled, Y ^a   Troen, H ^a   Masarwa, R ^a   Abu Ahmad, W ^a   Weintraub, M ^a   Revel Vilk, S ^a   Engelhard, D ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Bacteremia; Cancer; Children; Non fermentative Gram negative rods

Indexed keywords

AMIKACIN; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM;

ACINETOBACTER BAUMANNII; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; CELLULITIS; CHILD; CHILDHOOD CANCER; CHILDHOOD DISEASE; CLINICAL FEATURE; COMPARATIVE STUDY; DISEASE SEVERITY; ECTHYMA; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFANT; INFECTION; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; NON FERMENTATIVE GRAM NEGATIVE RODS BACTEREMIA; OUTCOME ASSESSMENT; PERIANAL ABSCESS; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SEPTIC SHOCK; SINUSITIS; SOFT TISSUE INFECTION; SOLID MALIGNANT NEOPLASM; STENOTROPHOMONAS MALTOPHILIA; TERTIARY CARE CENTER; COMPLICATION; DRUG EFFECTS; GRAM NEGATIVE AEROBIC RODS AND COCCI; INCIDENCE; ISRAEL; MICROBIOLOGY; MORTALITY; MULTIDRUG RESISTANCE; NEOPLASM; PRESCHOOL CHILD; RISK FACTOR; TREATMENT OUTCOME;

ADOLESCENT; BACTEREMIA; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GRAM-NEGATIVE AEROBIC RODS AND COCCI; HUMANS; INCIDENCE; INFANT; ISRAEL; MALE; NEOPLASMS; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 85012873735     PISSN: 03008126     EISSN: 14390973     Source Type: Journal    
DOI: 10.1007/s15010-017-0988-1     Document Type: Article

References (33)

1. Mikulska M, Viscoli C, Orasch C, Livermore DM, Averbuch D, Cordonnier C, Akova M. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect. 2014;68:321–31.
2. Gudiol C, Bodro M, Simonetti A, Tubau F, Gonzalez-Barca E, Cisnal M, Domingo-Domenech E, Jimenez L, Carratala J. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect. 2013;19:474–9.
3. El-Mahallawy HA, El-Wakil M, Moneer MM, Shalaby L. Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer. Pediatr Blood Cancer. 2011;57:283–8.
4. O’Connor D, Bate J, Wade R, Clack R, Dhir S, Hough R, Vora A, Goulden N, Samarasinghe S. Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003. Blood. 2014;124:1056–61.
5. Bakhshi S, Padmanjali KS, Arya LS. Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes. Pediatr Hematol Oncol. 2008;25:385–92.
6. Cattaneo C, Antoniazzi F, Casari S, Ravizzola G, Gelmi M, Pagani C, D’Adda M, Morello E, Re A, Borlenghi E, Manca N, Rossi G. P. aeruginosa bloodstream infections among hematological patients: an old or new question? Ann Hematol. 2012;91:1299–304.
7. Martino R, Gomez L, Pericas R, Salazar R, Sola C, Sierra J, Garau J. Bacteraemia caused by non-glucose-fermenting gram-negative bacilli and Aeromonas species in patients with haematological malignancies and solid tumours. Eur J Clin Microbiol Infect Dis. 2000;19:320–3.
8. Caselli D, Cesaro S, Ziino O, Zanazzo G, Manicone R, Livadiotti S, Cellini M, Frenos S, Milano GM, Cappelli B, Licciardello M, Beretta C, Arico M, Castagnola E. Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation. Haematologica. 2010;95:1612–5.
9. Castagnola E, Conte M, Parodi S, Papio F, Caviglia I, Haupt R. Incidence of bacteremias and invasive mycoses in children with high risk neuroblastoma. Pediatr Blood Cancer. 2007;49:672–7.
10. Haupt R, Romanengo M, Fears T, Viscoli C, Castagnola E. Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution. Eur J Cancer. 2001;37:2413–9.
11. Haeusler GM, Mechinaud F, Daley AJ, Starr M, Shann F, Connell TG, Bryant PA, Donath S, Curtis N. Antibiotic-resistant Gram-negative bacteremia in pediatric oncology patients–risk factors and outcomes. Pediatr Infect Dis J. 2013;32:723–6.
12. Averbuch D, Orasch C, Cordonnier C, Livermore DM, Mikulska M, Viscoli C, Gyssens IC, Kern WV, Klyasova G, Marchetti O, Engelhard D, Akova M. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica. 2013;98:1826–35.
13. Martino R, Santamaría A, Muñoz L, Pericas R, Altés A, Prats G, Sierra J. Bacteremia by Gram-negative bacilli in patients with hematologic malignancies. Acta Haematol. 1999;102:7–11.
14. Tada K, Kurosawa S, Hiramoto N, Okinaka K, Ueno N, Asakura Y, Kim SW, Yamashita T, Mori SI, Heike Y, Maeshima AM, Tanosaki R, Tobinai K, Fukuda T. Stenotrophomonas maltophilia infection in hematopoietic SCT recipients: high mortality due to pulmonary hemorrhage. Bone Marrow Transplant. 2013;48:74–9.
15. Miedema KG, Winter RH, Ammann RA, Droz S, Spanjaard L, de Bont ES, Kamps WA, van de Wetering MD, Tissing WJ. Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia–species distribution and susceptibility patterns. Support Care Cancer. 2013;21:2417–26.
16. Kagen J, Zaoutis TE, McGowan KL, Luan X, Shah SS. Bloodstream infection caused by Stenotrophomonas maltophilia in children. Pediatr Infect Dis J. 2007;26:508–12.
17. Segal SC, Zaoutis TE, Kagen J, Shah SS. Epidemiology of and risk factors for Acinetobacter species bloodstream infection in children. Pediatr Infect Dis J. 2007;26:920–6.
18. Costa Pde O, Atta EH, Silva AR. Infection with multidrug-resistant gram-negative bacteria in a pediatric oncology intensive care unit: risk factors and outcomes. J Pediatr (Rio J). 2015;91:435–41.
19. Ariffin H, Navaratnam P, Mohamed M, Arasu A, Abdullah WA, Lee CL, Peng LH. Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia. Int J Infect Dis. 2000;4:21–5.
20. Rosa RG, Goldani LZ, dos Santos RP. Risk factors for multidrug-resistant bacteremia in hospitalized cancer patients with febrile neutropenia: a cohort study. Am J Infect Control. 2014;42:74–6.
21. Gudiol C, Tubau F, Calatayud L, Garcia-Vidal C, Cisnal M, Sanchez-Ortega I, Duarte R, Calvo M, Carratala J. Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother. 2011;66:657–63.
22. Kang C-I, Song J-H, Chung DR, Peck KR, Yeom J-S, Son JS, Wi YM. Bloodstream infections in adult patients with cancer: clinical features and pathogenic significance of Staphylococcus aureus bacteremia. Support Care Cancer. 2012;20:2371–8.
23. Chiang MC, Kuo SC, Chen SJ, Yang SP, Lee YT, Chen TL, Fung CP. Clinical characteristics and outcomes of bacteremia due to different genomic species of Acinetobacter baumannii complex in patients with solid tumors. Infection. 2012;40:19–26.
24. Styczynski J, Czyzewski K, Wysocki M, Gryniewicz-Kwiatkowska O, Kolodziejczyk-Gietka A, Salamonowicz M, Hutnik L, Zajac-Spychala O, Zaucha-Prazmo A, Chelmecka-Wiktorczyk L, Siewiera K, Fraczkiewicz J, Malas Z, Tomaszewska R, Irga-Jaworska N, Plonowski M, Ociepa T, Pierlejewski F, Gamrot Z, Urbanek-Dadela A, Gozdzik J, Stolpa W, Dembowska-Baginska B, Perek D, Matysiak M, Wachowiak J, Kowalczyk J, Balwierz W, Kalwak K, Chybicka A, Badowska W, Szczepanski T, Drozynska E, Krawczuk-Rybak M, Urasinski T, Mlynarski W, Woszczyk M, Karolczyk G, Sobol-Milejska G, Gil L. Increased risk of infections and infection-related mortality in children undergoing haematopoietic stem cell transplantation compared to conventional anticancer therapy: a multicentre nationwide study. Clin Microbiol Infect. 2016;22:179 e1–e10.
25. Ammann RA, Laws HJ, Schrey D, Ehlert K, Moser O, Dilloo D, Bode U, Wawer A, Schrauder A, Cario G, Laengler A, Graf N, Furtwangler R, Simon A. Bloodstream infection in paediatric cancer centres–leukaemia and relapsed malignancies are independent risk factors. Eur J Pediatr. 2015;174:675–86.
26. Dix D, Cellot S, Price V, Gillmeister B, Ethier M-C, Johnston DL, Lewis V, Michon B, Mitchell D, Stobart K, Yanofsky R, Portwine C, Silva M, Bowes L, Zelcer S, Brossard J, Traubici J, Allen U, Beyene J, Sung L. Association between corticosteroids and infection, sepsis, and infectious death in pediatric acute myeloid leukemia (AML): results From the Canadian Infections in AML Research Group. Clin Infect Dis. 2012;55:1608–14.
27. Castagnola E, Caviglia I, Pistorio A, Fioredda F, Micalizzi C, Viscoli C, Haupt R. Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution. Eur J Cancer. 2005;41:1439–45.
28. Bochennek K, Hassler A, Perner C, Gilfert J, Schoning S, Klingebiel T, Reinhardt D, Creutzig U, Lehrnbecher T. Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004. Blood Cancer J. 2016;6:e382.
29. Castagnola E, Garre ML, Bertoluzzo L, Pignatelli S, Pavanello M, Caviglia I, Caruso S, Bagnasco F, Moroni C, Tacchella A, Haupt R. Epidemiology of febrile neutropenia in children with central nervous system tumor: results from a single center prospective study. J Pediatr Hematol Oncol. 2011;33:e310–5.
30. Mueller EL, Croop J, Carroll AE. Fever and neutropenia hospital discharges in children with cancer: a 2012 update. Pediatr Hematol Oncol. 2016;33:39–48.
31. Mueller EL, Walkovich KJ, Mody R, Gebremariam A, Davis MM. Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009. BMC Cancer. 2015;15:388.
32. Lehrnbecher T, Phillips R, Alexander S, Alvaro F, Carlesse F, Fisher B, Hakim H, Santolaya M, Castagnola E, Davis BL, Dupuis LL, Gibson F, Groll AH, Gaur A, Gupta A, Kebudi R, Petrilli S, Steinbach WJ, Villarroel M, Zaoutis T, Sung L. Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. J Clin Oncol. 2012;30:4427–38.
33. Bartholomew F, Aftandilian C, Andrews J, Gutierrez K, Luna-Fineman S, Jeng M. Evaluation of febrile, nonneutropenic pediatric oncology patients with central venous catheters who are not given empiric antibiotics. J Pediatr. 2015;166:157–62.