Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients

Journal of Infection

Volumn 68, Issue 4, 2014, Pages 321-331

  Mikulska, Małgorzata ^a   Viscoli, Claudio ^a   Orasch, Christina ^b   Livermore, David M ^c   Averbuch, Diana ^d   Cordonnier, Catherine ^e   Akova, Murat ^f  

^a UNIVERSITY OF GENOA   (Italy)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e HENRI MONDOR HOSPITAL   (France)

^f HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Antimicrobial resistance; Bloodstream infection; Cancer; Multidrug resistant (MDR) bacteria; Sepsis; Transplantation

Indexed keywords

AMINOGLYCOSIDE; CARBAPENEM; CEFTAZIDIME; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACINETOBACTER; AGE DISTRIBUTION; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BACTEREMIA; BACTERIUM ISOLATION; BLOODSTREAM INFECTION; CANCER PATIENT; COAGULASE NEGATIVE STAPHYLOCOCCUS; ENTEROBACTERIACEAE; ENTEROCOCCUS; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HEMATOLOGY; HUMAN; LEUKEMIA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA; QUESTIONNAIRE; STAPHYLOCOCCUS AUREUS;

ANTIMICROBIAL RESISTANCE; BLOODSTREAM INFECTION; CANCER; MULTIDRUG RESISTANT (MDR) BACTERIA; SEPSIS; TRANSPLANTATION;

ADULT; BACTEREMIA; BACTERIA; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; HEMATOLOGIC NEOPLASMS; HUMANS; NEOPLASMS; QUESTIONNAIRES;

EID: 84895921852     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2013.12.006     Document Type: Article

References (59)

1. Drgona L., Paul M., Bucaneve G., Calandra T., Menichetti F. The need for aminoglycosides in combination with beta-lactams for high-risk, febrile neutropaenic patients with leukaemia. Eur J Cancer Suppl 2007, 5:13-22.
2. EORTC International Antimicrobial Therapy Cooperative Group Gram-positive bacteraemia in granulocytopenic cancer patients. Eur J Cancer 1990, 26:569-574.
3. Klastersky J. Science and pragmatism in the treatment and prevention of neutropenic infection. J Antimicrob Chemother 1998, 41(Suppl. D):13-24.
4. Ortega M., Rovira M., Almela M., Marco F., de la Bellacasa J.P., Martinez J.A., et al. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann Hematol 2005, 84:40-46.
5. Collin B.A., Leather H.L., Wingard J.R., Ramphal R. Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis 2001, 33:947-953.
6. Haupt R., Romanengo M., Fears T., Viscoli C., Castagnola E. Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution. Eur J Cancer 2001, 37:2413-2419.
7. Oliveira A.L., de Souza M., Carvalho-Dias V.M., Ruiz M.A., Silla L., Tanaka P.Y., et al. Epidemiology of bacteremia and factors associated with multi-drug-resistant Gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transplant 2007, 39:775-781.
8. Jacobson K., Rolston K., Elting L., LeBlanc B., Whimbey E., Ho D.H. Susceptibility surveillance among Gram-negative bacilli at a cancer center. Chemotherapy 1999, 45:325-334.
9. Kamboj M., Chung D., Seo S.K., Pamer E.G., Sepkowitz K.A., Jakubowski A.A., et al. The changing epidemiology of vancomycin-resistant Enterococcus (VRE) bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Biol Blood Marrow Transplant 2010, 16:1576-1581.
10. Almyroudis N.G., Fuller A., Jakubowski A., Sepkowitz K., Jaffe D., Small T.N., et al. Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis 2005, 7:11-17.
11. Cappellano P., Viscoli C., Bruzzi P., Van Lint M.T., Pereira C.A., Bacigalupo A. Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantation. New Microbiol 2007, 30:89-99.
12. Dettenkofer M., Wenzler-Rottele S., Babikir R., Bertz H., Ebner W., Meyer E., et al. Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project. Clin Infect Dis 2005, 40:926-931.
13. Mikulska M., Del Bono V., Raiola A.M., Bruno B., Gualandi F., Occhini D., et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of Gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant 2009, 15:47-53.
14. Poutsiaka D.D., Price L.L., Ucuzian A., Chan G.W., Miller K.B., Snydman D.R. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant 2007, 40:63-70.
15. Trecarichi E.M., Tumbarello M., Caira M., Candoni A., Cattaneo C., Pastore D., et al. Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematological malignancies. Haematologica 2011, 96:e1-e3.
16. Busca A., Cavecchia I., Locatelli F., D'Ardia S., De Rosa F.G., Marmont F., et al. Blood stream infections after allogeneic stem cell transplantation: a single-center experience with the use of levofloxacin prophylaxis. Transpl Infect Dis 2011, 14:40-48.
17. Cattaneo C., Quaresmini G., Casari S., Capucci M.A., Micheletti M., Borlenghi E., et al. Recent changes in bacterial epidemiology and the emergence of fluoroquinolone-resistant Escherichia coli among patients with haematological malignancies: results of a prospective study on 823 patients at a single institution. J Antimicrob Chemother 2008, 61:721-728.
18. Chen C.Y., Tsay W., Tang J.L., Tien H.F., Chen Y.C., Chang S.C., et al. Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia. Epidemiol Infect 2010, 138:1044-1051.
19. Chong Y., Yakushiji H., Ito Y., Kamimura T. Cefepime-resistant Gram-negative bacteremia in febrile neutropenic patients with hematological malignancies. Int J Infect Dis 2010, 14(Suppl. 3):e171-e175.
20. Paul M., Gafter-Gvili A., Leibovici L., Bishara J., Levy I., Yaniv I., et al. The epidemiology of bacteremia with febrile neutropenia: experience from a single center, 1988-2004. Isr Med Assoc J 2007, 9:424-429.
21. Yazaki M., Atsuta Y., Kato K., Kato S., Taniguchi S., Takahashi S., et al. Incidence and risk factors of early bacterial infections after unrelated cord blood transplantation. Biol Blood Marrow Transplant 2009, 15:439-446.
22. Gudiol C., Tubau F., Calatayud L., Garcia-Vidal C., Cisnal M., Sanchez-Ortega I., et al. Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 2011, 66:657-663.
23. Guven G.S., Uzun O., Cakir B., Akova M., Unal S. Infectious complications in patients with hematological malignancies consulted by the Infectious Diseases team: a retrospective cohort study (1997-2001). Support Care Cancer 2006, 14:52-55.
24. Horasan E.S., Ersoz G., Tombak A., Tiftik N., Kaya A. Bloodstream infections and mortality-related factors in febrile neutropenic cancer patients. Med Sci Monit 2011, 17:CR304-CR309.
25. Kanafani Z.A., Dakdouki G.K., El-Chammas K.I., Eid S., Araj G.F., Kanj S.S. Bloodstream infections in febrile neutropenic patients at a tertiary care center in Lebanon: a view of the past decade. Int J Infect Dis 2007, 11:450-453.
26. Klastersky J., Ameye L., Maertens J., Georgala A., Muanza F., Aoun M., et al. Bacteraemia in febrile neutropenic cancer patients. Int J Antimicrob Agents 2007, 30(Suppl. 1):S51-S59.
27. Malagola M., Peli A., Damiani D., Candoni A., Tiribelli M., Martinelli G., et al. Incidence of bacterial and fungal infections in newly diagnosed acute myeloid leukaemia patients younger than 65yr treated with induction regimens including fludarabine: retrospective analysis of 224 cases. Eur J Haematol 2008, 81:354-363.
28. Jathavedam A., Feldman D.R., Ishill N., Turkula S., Patil S., Bosl G.J., et al. Infectious complications from high-dose chemotherapy and autologous stem cell transplantation for metastatic germ cell tumors. Biol Blood Marrow Transplant 2008, 14:595-600.
29. Moreno A., Cervera C., Gavalda J., Rovira M., de la Camara R., Jarque I., et al. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant 2007, 7:2579-2586.
30. Norgaard M., Larsson H., Pedersen G., Schonheyder H.C., Sorensen H.T. Risk of bacteraemia and mortality in patients with haematological malignancies. Clin Microbiol Infect 2006, 12:217-223.
31. Ritchie S., Palmer S., Ellis-Pegler R. High-risk febrile neutropenia in Auckland 2003-2004: the influence of the microbiology laboratory on patient treatment and the use of pathogen-specific therapy. Intern Med J 2007, 37:26-31.
32. Rolston K.V., Yadegarynia D., Kontoyiannis D.P., Raad I.I., Ho D.H. The spectrum of Gram-positive bloodstream infections in patients with hematologic malignancies, and the invitro activity of various quinolones against Gram-positive bacteria isolated from cancer patients. Int J Infect Dis 2006, 10:223-230.
33. Safdar A., Rodriguez G.H., Balakrishnan M., Tarrand J.J., Rolston K.V. Changing trends in etiology of bacteremia in patients with cancer. Eur J Clin Microbiol Infect Dis 2006, 25:522-526.
34. Trecarichi E.M., Tumbarello M., Spanu T., Caira M., Fianchi L., Chiusolo P., et al. Incidence and clinical impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies. J Infect 2009, 58:299-307.
35. Tumbarello M., Spanu T., Caira M., Trecarichi E.M., Laurenti L., Montuori E., et al. Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagn Microbiol Infect Dis 2009, 64:320-326.
36. Velasco E., Byington R., Martins C.A., Schirmer M., Dias L.M., Goncalves V.M. Comparative study of clinical characteristics of neutropenic and non-neutropenic adult cancer patients with bloodstream infections. Eur J Clin Microbiol Infect Dis 2006, 25:1-7.
37. Yoshida M., Akiyama N., Fujita H., Miura K., Miyatake J., Handa H., et al. Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group. Int J Hematol 2011, 93:66-73.
38. Prabhash K., Medhekar A., Ghadyalpatil N., Noronha V., Biswas S., Kurkure P., et al. Blood stream infections in cancer patients: a single center experience of isolates and sensitivity pattern. Indian J Cancer 2010, 47:184-188.
39. Huang C. Antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern Taiwan 2011.
40. Al-Tonbary Y.A., Soliman O.E., Sarhan M.M., Hegazi M.A., El-Ashry R.A., El-Sharkawy A.A., et al. Nosocomial infections and fever of unknown origin in pediatric hematology/oncology unit: a retrospective annual study. World J Pediatr 2011, 7:60-64.
41. Sayed H.A., El-Mahallawy H.A., Kaddah A.M., Ismael H.T., Talaat S.M. Profile of infections in newly diagnosed patients with acute leukemia during the induction phase of treatment. J Egypt Natl Canc Inst 2009, 21:315-322.
42. Simon A., Ammann R.A., Bode U., Fleischhack G., Wenchel H.M., Schwamborn D., et al. Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hospitals in Germany and Switzerland. BMC Infect Dis 2008, 8:70.
43. Laws H.J., Schneider D.T., Janssen G., Wessalowski R., Dilloo D., Meisel R., et al. Trends in infections in children with malignant disease in 2000: comparison of data of 1980/81. Pediatr Hematol Oncol 2007, 24:343-354.
44. Katsimpardi K., Papadakis V., Pangalis A., Parcharidou A., Panagiotou J.P., Soutis M., et al. Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment. Support Care Cancer 2006, 14:277-284.
45. Asturias E.J., Corral J.E., Quezada J. Evaluation of six risk factors for the development of bacteremia in children with cancer and febrile neutropenia. Curr Oncol 2010, 17:59-63.
46. Bakhshi S., Padmanjali K.S., Arya L.S. Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes. Pediatr Hematol Oncol 2008, 25:385-392.
47. Greenberg D., Moser A., Yagupsky P., Peled N., Hofman Y., Kapelushnik J., et al. Microbiological spectrum and susceptibility patterns of pathogens causing bacteraemia in paediatric febrile neutropenic oncology patients: comparison between two consecutive time periods with use of different antibiotic treatment protocols. Int J Antimicrob Agents 2005, 25:469-473.
48. Castagnola E., Caviglia I., Pistorio A., Fioredda F., Micalizzi C., Viscoli C., et al. Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution. Eur J Cancer 2005, 41:1439-1445.
49. Castagnola E., Haupt R., Micozzi A., Caviglia I., Testi A.M., Giona F., et al. Differences in the proportions of fluoroquinolone-resistant Gram-negative bacteria isolated from bacteraemic children with cancer in two Italian centres. Clin Microbiol Infect 2005, 11:505-507.
50. Castagnola E., Fontana V., Caviglia I., Caruso S., Faraci M., Fioredda F., et al. A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation. Clin Infect Dis 2007, 45:1296-1304.
51. Castagnola E., Bagnasco F., Faraci M., Caviglia I., Caruso S., Cappelli B., et al. Incidence of bacteremias and invasive mycoses in children undergoing allogeneic hematopoietic stem cell transplantation: a single center experience. Bone Marrow Transplant 2008, 41:339-347.
52. Castagnola E., Rossi M.R., Cesaro S., Livadiotti S., Giacchino M., Zanazzo G., et al. Incidence of bacteremias and invasive mycoses in children with acute non-lymphoblastic leukemia: results from a multi-center Italian study. Pediatr Blood Cancer 2010, 55:1103-1107.
53. Agyeman P., Aebi C., Hirt A., Niggli F.K., Nadal D., Simon A., et al. Predicting bacteremia in children with cancer and fever in chemotherapy-induced neutropenia: results of the prospective multicenter SPOG 2003 FN study. Pediatr Infect Dis J 2011, 30:e114-e119.
54. Kersun L.S., Propert K.J., Lautenbach E., Bunin N., Demichele A. Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxis. Pediatr Blood Cancer 2005, 45:162-169.
55. Caselli D., Cesaro S., Ziino O., Zanazzo G., Manicone R., Livadiotti S., et al. Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation. Haematologica 2010, 95:1612-1615.
56. Gudiol C., Bodro M., Simonetti A., Tubau F., Gonzalez-Barca E., Cisnal M., et al. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect 2012, 19:474-479.
57. EARSS The European Antimicrobial Resistance Surveillance System (EARSS) annual report; on-going surveillance of S. pneumoniae, S. aureus, E. coli, E. faecium, E. faecalis, K. pneumoniae, P. aeruginosa 2008, Available at:. http://www.hpsc.ie/hpsc/A-Z/MicrobiologyAntimicrobialResistance/EuropeanAntimicrobialResistanceSurveillanceSystemEARSS/.
58. Spellberg B., Guidos R., Gilbert D., Bradley J., Boucher H.W., Scheld W.M., et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis 2008, 46:155-164.
59. Talbot G.H. The antibiotic development pipeline for multidrug-resistant Gram-negative bacilli: current and future landscapes. Infect Control Hosp Epidemiol 2010, 31(Suppl. 1):S55-S58.