Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia-species distribution and susceptibility patterns

Supportive Care in Cancer

Volumn 21, Issue 9, 2013, Pages 2417-2426

  Miedema, Karin G E ^a   Winter, Rik H L J ^b   Ammann, Roland A ^c   Droz, Sara ^c   Spanjaard, Lodewijk ^d   De Bont, Eveline S J M ^a   Kamps, Willem A ^a   Van De Wetering, Marianne D ^e   Tissing, Wim J E ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY OF BERN   (Switzerland)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Bacteremia; Cancer; Children; Febrile neutropenia; Susceptibility

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; CARBAPENEM DERIVATIVE; CEFRADINE; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; ERYTHROMYCIN; FLUCLOXACILLIN; GENTAMICIN; IMIPENEM; MACROLIDE; MEROPENEM; PENICILLIN DERIVATIVE; PHENETICILLIN; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; RIFAMPICIN; TETRACYCLINE; TOBRAMYCIN; VANCOMYCIN;

ADOLESCENT; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BACTERIUM; BLOOD CULTURE; CHILD; CHILDHOOD CANCER; FEBRILE NEUTROPENIA; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; NETHERLANDS; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SCHOOL CHILD; SPECIES DISTRIBUTION; STREPTOCOCCUS VIRIDANS INFECTION; SWITZERLAND;

ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTEREMIA; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; FEBRILE NEUTROPENIA; FEMALE; FEVER; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INFANT; MALE; MICROBIAL SENSITIVITY TESTS; NEOPLASMS; NETHERLANDS; SWITZERLAND;

EID: 84881256837     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-013-1797-4     Document Type: Article

References (20)

1. Katz JA, Mustafa MM (1993) Management of fever in granulocytopenic children with cancer. Pediatr Infect Dis J 12(4):330-337
2. Bodey GP, Rodriguez V, Chang HY, Narboni (1978) Fever and infection in leukemic patients: a study of 494 consecutive patients. Cancer 41(4):1610-1622 (Pubitemid 8333322)
3. Bucaneve G, Micozzi A, Menichetti F, Martino P, Dionisi MS, Martinelli G et al (2005) Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 353(10):977-987 (Pubitemid 41262332)
4. Kurt B, Flynn P, Shenep JL, Pounds S, Lensing S, Ribeiro RC et al (2008) Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia. Cancer 113(2):376-382
5. Gafter-Gvili A, Fraser A, Paul M, Vidal L, Lawrie TA, van de Wetering MD, et al. (2012) Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. Cochrane Database Syst Rev (4):CD004386
6. Zinner SH (1999) Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. Clin Infect Dis 29(3):490-494 (Pubitemid 29439940)
7. Hann I, Viscoli C, Paesmans M, Gaya H, Glauser M, International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC) (1997) A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. Br J Haematol 99(3):580-588 (Pubitemid 27519860)
8. Paulus S, Dobson S, Rassekh S, Blondel-Hill E (2009) In vitro inferiority of ceftazidime compared with other beta-lactams for viridans group Streptococcus bacteremia in pediatric oncology patients: implications for antibiotic choices. J Pediatr Hematol Oncol 31(4):267-269
9. Greenberg D, Moser A, Yagupsky P, Peled N, Hofman Y, Kapelushnik J et al (2005) Microbiological spectrum and susceptibility patterns of pathogens causing bacteraemia in paediatric febrile neutropenic oncology patients: comparison between two consecutive time periods with use of different antibiotic treatment protocols. Int J Antimicrob Agents 25(6):469-473 (Pubitemid 40732600)
10. El-Mahallawy HA, El-Wakil M, Moneer MM, Shalaby L (2011) Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer. Pediatr Blood Cancer 57(2):283-288
11. Caselli D, Cesaro S, Ziino O, Zanazzo G, Manicone R, Livadiotti S et al (2010) Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation. Haematologica 95(9):1612-1615
12. Howard DH, Scott RD 2nd, Packard R, Jones D (2003) The global impact of drug resistance. Clin Infect Dis 35(Suppl 1):S4-S10 (Pubitemid 36140464)
13. Agyeman P, Aebi C, Hirt A, Niggli FK, Nadal D, Simon A et al (2011) Predicting bacteremia in children with cancer and fever in chemotherapy-induced neutropenia: results of the prospective multicenter SPOG 2003 FN study. Pediatr Infect Dis J 30(7):e114-e119
14. Nethmap (2011) Available at: http://www.swab.nl/swab/cms3.nsf/uploads/ 35ACD3A546C31716C12578BF002EDC4F/$FILE/NethMap2011.pdf. Accessed 20 Jan 2012
15. Castagnola E, Haupt R, Micozzi A, Caviglia I, Testi AM, Giona F et al (2005) Differences in the proportions of fluoroquinolone-resistant Gram-negative bacteria isolated from bacteraemic children with cancer in two Italian centres. Clin Microbiol Infect 11(6):505-507 (Pubitemid 40744401)
16. Abe M, Kamijo T, Matsuzawa S, Miki J, Nakazawa Y, Sakashita K et al (2009) High incidence of meropenem resistance among alpha-hemolytic streptococci in children with cancer. Pediatr Int 51(1):103-106
17. Patterson JE, Hardin TC, Kelly CA, Garcia RC, Jorgensen JH (2000) Association of antibiotic utilization measures and control of multiple-drug resistance in Klebsiella pneumoniae. Infect Control Hosp Epidemiol 21(7):455-458 (Pubitemid 30620213)
18. Rangaraj G, Granwehr BP, Jiang Y, Hachem R, Raad I (2010) Perils of quinolone exposure in cancer patients: breakthrough bacteremia with multidrug-resistant organisms. Cancer 116(4):967-973
19. Kennedy HF, Morrison D, Kaufmann ME, Jackson MS, Bagg J, Gibson BE et al (2000) Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient. J Med Microbiol 49(4):367-370 (Pubitemid 30189472)
20. Murono K, Hirano Y, Koyano S, Ito K, Fujieda K (2003) Molecular comparison of bacterial isolates from blood with strains colonizing pharynx and intestine in immunocompromised patients with sepsis. J Med Microbiol 52(Pt 6):527-530 (Pubitemid 36774242)