Functional reconstitution of a fungal natural product gene cluster by advanced genome editing

ACS Synthetic Biology

Volumn 6, Issue 1, 2017, Pages 62-68

  Weber, Jakob ^a,b   Valiante, Vito ^a   Nødvig, Christina S ^c   Mattern, Derek J ^a,b   Slotkowski, Rebecca A ^a   Mortensen, Uffe H ^c   Brakhage, Axel A ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Aspergillus f umigatus; CRISPR Cas9; Gene editing; Split marker; Trypacidin

Indexed keywords

NATURAL PRODUCT; POLYKETIDE SYNTHASE; TRYPACIDIN; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; MYCOTOXIN;

ARTICLE; ASPERGILLUS FUMIGATUS; CRISPR-CAS9 SYSTEM; DRUG SYNTHESIS; FUNGAL GENE; FUNGAL STRAIN; GENE CLUSTER; GENE EDITING; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; BIOSYNTHESIS; CRISPR CAS SYSTEM; GENETICS; HUMAN; METABOLISM; MULTIGENE FAMILY; PATHOGENICITY; PROCEDURES; SYNTHETIC BIOLOGY;

ASPERGILLUS FUMIGATUS; BIOLOGICAL PRODUCTS; CRISPR-CAS SYSTEMS; GENE EDITING; GENES, FUNGAL; HUMANS; MULTIGENE FAMILY; MYCOTOXINS; POLYKETIDE SYNTHASES; SYNTHETIC BIOLOGY;

EID: 85012831291     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.6b00203     Document Type: Article

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