Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A

Regulatory Toxicology and Pharmacology

Volumn 85, Issue , 2017, Pages 70-78

  von Goetz, N ^a   Pirow, R ^b   Hart, A ^c   Bradley, E ^c   Pocas F ^d   Arcella, D ^e   Lillegard, I T L ^f   Simoneau, C ^g   van Engelen, J ^h   Husoy, T ⁱ   Theobald, A ^e   Leclercq, C ^j  

^a ETH ZURICH   (Switzerland)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^c FOOD AND ENVIRONMENT RESEARCH AGENCY   (United Kingdom)

^d CBQF CENTRO DE BIOTECNOLOGIA E QUÍMICA FINA LABORATÓRIO ASSOCIADO   (Portugal)

^e EUROPEAN FOOD SAFETY AUTHORITY   (Italy)

^f Norwegian Scientific Committee for Food and Environment   (Norway)

^g JOINT RESEARCH CENTRE   (Italy)

^h NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

ⁱ NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^j ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

more..

Author keywords

Aggregate; Backward modeling; Biomonitoring; Bisphenol A; Dietary; EFSA; European food safety authority; Exposure; Multi route; Source to dose modeling

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; COSMETIC; BENZHYDRYL DERIVATIVE; PHENOL DERIVATIVE; POLLUTANT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BACKWARD MODELING; BIOLOGICAL MONITORING; CALCULATION; CANNED FOOD; CHEMICAL ANALYSIS; CHILD; EUROPEAN FOOD SAFETY AUTHORITY; EXPOSURE; FEMALE; FOOD; FOOD SAFETY; HUMAN; INFANT; MATHEMATICAL MODEL; MEDICAL SOCIETY; MIDDLE AGED; PAPER; PRESCHOOL CHILD; RISK ASSESSMENT; SCHOOL CHILD; SKIN ABSORPTION; SOURCE TO DOSE MODELING; TOXICITY TESTING; UNCERTAINTY; YOUNG ADULT; AGED; ANALYSIS; DIET; ENVIRONMENTAL EXPOSURE; EUROPE; FOOD CONTAMINATION; GOVERNMENT; MALE; NEWBORN; POLLUTANT; THEORETICAL MODEL;

ADOLESCENT; ADULT; AGED; BENZHYDRYL COMPOUNDS; CHILD; CHILD, PRESCHOOL; DIET; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; EUROPE; FEMALE; FOOD CONTAMINATION; GOVERNMENT AGENCIES; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; MODELS, THEORETICAL; PAPER; PHENOLS; SKIN ABSORPTION; YOUNG ADULT;

EID: 85012302327     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2017.02.004     Document Type: Article

References (48)

1. Angerer, J., Ewers, U., Wilhelm, M., Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 210 (2007), 201–228.
2. ANSES (Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail), Rapport d'étude de l'Anses relatif à “Substitution du bisphénol A - L'identification des dangers des substituts potentiels au bisphénol A - Etat des lieux sur les alternatives au bisphénol A” en complément du rapport de l'Anses relatif à l’évaluation des risques liés au Bisphénol A (BPA) pour la santé humaine et aux données toxicologiques et d'usage des bisphénols S, F, M, B, AP, AF, et BADGE Avis signé le 25/03/2013. 2013 https://www.anses.fr/fr/system/files/CHIM2009sa0331Ra-3.pdf.
3. Arcella D, 2016, personal communication.
4. Aylward, L.L., Hays, S.M., Smolders, R., Koch, H.M., Cocker, J., Jones, K., Warren, N., Levy, L., Bevan, R., Sources of variability in biomarker concentrations. Journal of Toxicology and environmental health B 17 (2014), 45–61, 10.1080/10937404.2013.864250.
5. Beausoleil, et al. Low dose effects and non-monotonic dose responses for endocrine active chemicals: science to practice workshop: workshop summary. Chemosphere 93 (2013), 847–856, 10.1016/j.chemosphere.2013.06.043.
6. Biedermann, S., Tschudin, P., Grob, K., Transfer of bisphenol A from thermal printer paper to the skin. Anal. Bioanal. Chem. 398 (2010), 571–576, 10.1007/s00216-010-3936-9.
7. Cacho, J.I., Campillo, N., Viñas, P., Hernández-Córdoba, M., Stir bar sorptive extraction coupled to gas chromatography–mass spectrometry for the determination of bisphenols in canned beverages and filling liquids of canned vegetables. J. Chromatogr. A 1247 (2012), 146–153, 10.1016/j.chroma.2012.05.064.
8. Calafat, A.M., Ye, X., Wong, L.Y., Reidy, J.A., Needham, L.L., Exposure of the US population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ. Health Perspect. 116 (2008), 39–44.
9. Christensen, K.L., Lorber, M., Koch, H.M., Kolossa-Gehring, M., Morgan, M.K., Population variability of phthalate metabolites and bisphenol A concentrations in spot urine samples versus 24- or 48-h collections. J. Expo. Sci. Environ. Epidemiol. 22 (2012), 632–640, 10.1038/jes.2012.52.
10. Delmaar, J.E., van der Zee Park, M., van Engelen, J.G.M., ConsExpo - Consumer Exposure and Uptake Models. RIVM. Report 320104004, 2005.
11. Demierre, A.L., Peter, R., Oberli, A., Bourqui-Pittet, M., Dermal penetration of bisphenol A in human skin contributes marginally to total exposure. Toxicol. Lett. 213 (2012), 305–308, 10.1016/j.toxlet.2012.07.001.
12. Doerge, D.R., Twaddle, N.C., Woodling, K.A., Fisher, J.W., Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Toxicol. Appl. Pharmacol. 248 (2010), 1–11.
13. ECHA (European Chemicals Agency), Opinion on the Annex XV Dossier Proposing Restrictions on Bisphenol a. available at: 2015 https://www.echa.europa.eu/documents/10162/209030fc-ca4b-4745-97b6-98bfc4d6bdd3 accessed on 27.09.2016.
14. EFSA (European Food Safety Authority), Guidance of the Scientific Committee on a request from EFSA related to uncertainties in dietary exposure assessment. EFSA J. 438 (2006), 1–54.
15. EFSA (European Food Safety Authority), Scientific Report of EFSA: management of left-censored data in dietary exposure assessment of chemical substances. EFSA J., 8(3), 2010, 10.2903/j.efsa.2010.1557 1557, 96 pp.
16. EFSA (European Food Safety Authority), Use of the EFSA comprehensive european food consumption database in exposure assessment. EFSA J., 9(3), 2011, 2097, 10.2903/j.efsa.2011.2097.
17. EFSA CEF Panel, Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. 2015 EFSA J., 13(1), 2015, 10.2903/j.efsa.2015.3978 3978, 23 pp.
18. EFSA CEF Panel, Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Part I – Exposure assessment. 2015 EFSA J., 13(1), 2015 3978, 396 pp.
19. EFSA CEF Panel, Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: PART II – Toxicological assessment and risk characterisation. 2015 EFSA J., 13(1), 2015 3978, 621 pp.
20. EU commission regulation No 321/2011 of 1 April 2011, amending Regulation (EU) No 10/2011 as regards the restriction of use of Bisphenol A in plastic infant feeding bottles.
21. Geens, T., Roosens, L., Neels, H., Covaci, A., Assessment of human exposure to bisphenol-A, triclosan and tetrabromobisphenol-A through indoor dust intake in Belgium. Chemosphere 76 (2009), 755–760, 10.1016/j.chemosphere.2009.05.024.
22. Geens, T., Goeyens, L., Covaci, A., Are potential sources for human exposure to bisphenol-A overlooked?. Int. J. Hyg. Environ. Health 214 (2011), 339–347, 10.1016/j.ijheh.2011.04.005.
23. Hengstler, J.G., Foth, H., Gebel, T., Kramer, P.J., Lilienblum, W., Schweinfurth, H., Völkel, W., Wollin, K.M., Gundert-Remy, U., Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. Crit. Rev. Toxicol. 41 (2011), 263–291.
24. JRC, ExpoFacts Database. available at: 2016 http://expofacts.jrc.ec.europa.eu/ accessed on 10.06.2016.
25. Kang, Y.G., Kim, J.Y., Kim, J., Won, P.J., Nam, J.H., Release of bisphenol A from resin composite used to bond orthodontic lingual retainers. Am. J. Orthod. Dentofac. Orthop. 140 (2011), 779–789, 10.1016/j.ajodo.2011.04.022.
26. KEMI (Swedish Chemicals Agency), Bisfenol a I Leksaker Och Barnartiklar. 6/12. KEMI, Sundbyberg, Sweden. 2012, 55 (in Swedish).
27. KEMI (Swedish Chemicals Agency), Emission of Bisphenol a (BPA) from Restored Drinking Water Pipes—report from a Governmental aC. 7/13. KEMI, Sundbyberg, Sweden., 2013, 86.
28. Klecka, G.M., Staples, C.A., Clark, K.E., Van Der Hoeven, N., Thomas, D.E., Hentges, S.G., Exposure analysis of bisphenol A in surface water systems in North America and Europe. Environ. Sci. Technol. 43 (2009), 6145–6615.
29. Lakind, J.S., Naiman, D.Q., Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003–2004 NHANES urinary BPA data. J. Expo. Sci. Environ. Epidemiol. 18 (2008), 608–615 http://dx.doi.org/10.1038/jesee.2008.20.
30. Lassen, C., Mikkelsen, H.S., Brandt, U.K., Migration of Bisphenol a from Cash Register Receipts and Baby Dummies. Survey of Chemical Substances in Consumer Product, 110 2011 Danish Ministry of the Environment. 2011, Environmental Protection Agency, Copenhagen, Denmark, 67 accessible at http://www2.mst.dk/udgiv/publications/2011/04/978-87-92708-93-9.pdf.
31. Lorenz, C., von Goetz, N., Scheringer, M., Wormuth, M., Hungerbühler, K., Exposure of German consumers to engineered nanoparticles in cosmetics and personal care products. Nanotoxicology 5:1 (2011), 12–29, 10.3109/17435390.2010.484554.
32. Manová, E., von Goetz, N., Keller, C., Siegrist, M., Hungerbühler, K., Use patterns of leave-on personal care products among Swiss-German children, adolescents, and adults. Int. J. Environ. Res. Public Health 10 (2013), 2778–2798, 10.3390/ijerph10072778.
33. Meek, B., Boobis, A., Crofton, K., Heinemeyer, G., van Raaij, M., Vickers, C., Risk assessment of combined exposure to multiple chemicals: a WHO/IPCS framework. Regul. Toxicol. Pharmacol. 60 (2011), S1–S14, 10.1016/j.yrtph.2011.03.010.
34. Merchant Research and Consulting Ltd, http://mcgroup.co.uk/news/20131108/bpa-production-grew-372000-tonnes.html, 2013 accessed on 11.06.2015.
35. Merten, C., Ferrari, P., Bakker, M., Boss, A., Hearty, A., Leclercq, C., Lindtner, O., Tlustos, C., Verger, P., Volatier, J.L., Arcella, D., Methodological characteristics of the national dietary surveys carried out in the european union as included in the european food safety authority (EFSA) comprehensive european food consumption database. Food Addit. Contam. 28:8 (2011), 979–995, 10.1080/19440049.2011.576440.
36. Östberg, T., Noaksson, E., BPA I Svenska Kvitton. Proceedings of the Tillämpad Grön KemI, Jämtlands Läns Landsting. (In Swedish), 2010.
37. PRWeb, http://www.prweb.com/releases/2014/04/prweb11761146.htm, 2014 accessed on 11.06.2015.
38. Teeguarden, J.G., Twaddle, N.V., Churchwell, M.I., Yang, X., Fisher, J.W., Seryak, L.M., Doerge, D.R., 24-hour human urine and serum profiles of bisphenol A: evidence against sublingual absorption following ingestion in soup. Toxicol. Appl. Pharmacol. 288 (2015), 131–142.
39. Thayer, K.A., Taylor, K.W., Garantziotis, S., Schurman, S.H., Kissling, G.E., Hunt, D., Herbert, B., Church, R., Jankowich, R., Churchwell, M.I., Scheri, R.C., Birnbaum, L.S., Bucher, J.R., Bisphenol A, Bisphenol S, and 4-Hydroxyphenyl 4-Isoprooxyphenylsulfone (BPSIP) in urine and blood of cashiers. Environ. Health Perspect. 124:4 (2016), 437–444.
40. Thayer, K.A., Doerge, D.R., Hunt, D., Schurman, S.H., Twaddle, N.C., Churchwell, M.I., Garantziotis, S., Kissling, G.E., Easterling, M.R., Bucher, J.R., Birnbaum, L.S., Pharmacokinetics of bisphenol A in humans following a single oral administration. Environ. Int. 83 (2015), 107–115.
41. Trudel, D., Tlustos, C., von Goetz, N., Scheringer, M., Hungerbühler, K., PBDE exposure from food in Ireland: optimising data exploitation in probabilistic exposure modelling. J. Expo. Sci. Environ. Epidemiol. 21 (2011), 565–575, 10.1038/jes.2010.41.
42. UNEP-WHO, State of the Science of Endocrine Disrupting Chemicals 2012, Summary for Decision Makers. 2013 available at: http://www.unep.org/pdf/WHO_HSE_PHE_IHE_2013.1_eng.pdf accessed on 10.06.2016.
43. US-EPA, Exposure Factors Handbook, Edition (Final). U.S. 2011, Environmental Protection Agency, Washington, DC EPA/600/R-09/052F, available online at: http://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252 accessed on 14.06.2016.
44. Völkel, W., Colnot, T., Csanady, G.A., Filser, J.G., Dekant, W., Metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem. Res. Toxicol. 15 (2002), 1281–1287.
45. Von Goetz, N., Wormuth, M., Scheringer, M., Hungerbühler, K., Bisphenol A: how the most relevant exposure sources contribute to total consumer exposure. Risk Anal. 30:3 (2010), 473–487, 10.1111/j.1539-6924.2009.01345.x.
46. WHO, Principles and Methods for Risk Assessment of Chemicals in Food, Chapter 6: Dietary Exposure Assessment of Chemicals in Food. 2009 available online at: http://www.who.int/foodsafety/publications/chemical-food/en/ accessed on 27.09.2016.
47. WUR (Rijkswaterstaat Institute for Coastal and Marine Management (RIKZ)), Chemical Study on Bisphenol a. RIKZ/2001.027. 2001, 94 Available online http://edepot.wur.nl/174301.
48. Ye, Y., Wong, L.Y., Bishop, A.M., Calafat, A.M., Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections. Environ. Health Perspect. 119 (2011), 983–988.