Trehalose 6,6′-dimycolate - A coat to regulate tuberculosis immunopathogenesis

Tuberculosis

Volumn 93, Issue SUPPL., 2013, Pages

  Welsh, Kerry J ^a   Hunter, Robert L ^a   Actor, Jeffrey K ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Cord; Factor; TDM; Trehalose 6,6 dimycolate; Tuberculosis

Indexed keywords

ANTIBIOTIC AGENT; CORD FACTOR; GLYCOLIPID;

ADAPTIVE IMMUNITY; ANTICOAGULATION; ANTIGEN PRESENTATION; ARTICLE; ASPIRATION PNEUMONIA; BACILLI; GRANULOMA; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LUNG ALVEOLUS MACROPHAGE; LUNG TUBERCULOSIS; MACROPHAGE; MICELLE; MOLECULAR PATHOLOGY; MYCOBACTERIUM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

CORD FACTOR; TREHALOSE 6,6′-DIMYCOLATE; TUBERCULOSIS TDM;

ADJUVANTS, IMMUNOLOGIC; CORD FACTORS; DISEASE PROGRESSION; FEMALE; GRANULOMA, RESPIRATORY TRACT; HUMANS; MALE; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 84891595604     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/S1472-9792(13)70003-9     Document Type: Article

References (98)

1. WHO WHO Global Tuberculosis Report 2012 2012 World Health Organization Geneva
2. R Dubos, G Dubos The White Plague. Tuberculosis, Man, and Society 1987 Rutgers Univesity Press Brunswick, NJ
3. NM Parrish, JD Dick, WR Bishai Mechanisms of latency in Mycobacterium tuberculosis Trends Microbiol 6 1998 107 112
4. A Alcais, C Fieschi, L Abel, JL Casanova Tuberculosis in children and adults: two distinct genetic diseases J Exp Med 202 2005 1617 1621
5. RJ Anderson Chemical Investigation of Biologically Active Lipoids of Tubercle Bacilli Proc Natl Acad Sci U S A 15 1929 628 633
6. GS Besra, D Chatterjee Lipids and carbohydrates of Mycobacterium tuberculosis. BR Bloom Tuberculosis: pathogenesis, protection, and control 1994 ASM Press Washington, D.C.
7. RE Lee, PJ Brennan, GS Besra Mycobacterium tuberculosis cell envelope Curr Top Microbiol Immunol 215 1996 1 27
8. RL Hunter, MR Olsen, C Jagannath, JK Actor Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease Ann Clin Lab Sci 36 2006 371 386
9. PC Karakousis, WR Bishai, SE Dorman Mycobacterium tuberculosis cell envelope lipids and the host immune response Cell Microbiol 6 2004 105 116
10. RL Hunter, M Olsen, C Jagannath, JK Actor Trehalose 6,6′-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice Am J Pathol 168 2006 1249 1261
11. H Bloch Studies on the virulence of tubercle bacilli; isolation and biological properties of a constituent of virulent organisms J Exp Med 91 1950 197 218
12. H Bloch Virulence of mycobacteria Bibl Tuberc 9 1955 49 61
13. H Bloch, H Noll Studies on the virulence of Tubercle bacilli; the effect of cord factor on murine tuberculosis Br J Exp Pathol 36 1955 8 17
14. H Noll, H Bloch Studies on the chemistry of the cord factor of Mycobacterium tuberculosis J Biol Chem 214 1955 251 265
15. H Noll, H Bloch, J Asselineau, E Lederer The chemical structure of the cord factor of Mycobacterium tuberculosis Biochimica et biophysica acta 20 1956 299 309
16. CE Barry 3rd, RE Lee, K Mdluli, AE Sampson, BG Schroeder, RA Slayden, Y Yuan Mycolic acids: structure, biosynthesis and physiological functions Prog Lipid Res 37 1998 143 179
17. Y Fujita, T Naka, MR McNeil, I Yano Intact molecular characterization of cord factor (trehalose 6,6′-dimycolate) from nine species of mycobacteria by MALDI-TOF mass spectrometry Microbiology 151 2005 3403 3416
18. Y Fujita, Y Okamoto, Y Uenishi, M Sunagawa, T Uchiyama, I Yano Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice Microb Pathog 43 2007 10 21
19. DG Russell, PJ Cardona, MJ Kim, S Allain, F Altare Foamy macrophages and the progression of the human tuberculosis granuloma Nature Immunology 10 2009 943 948
20. AM Cooper, A Solache, SA Khader Interleukin-12 and tuberculosis: an old story revisited Curr Opin Immunol 19 2007 441 447
21. JK Actor, RL Hunter, C Jagannath ImmunoPathology of Tuberculosis DS Zander HH Popper J Jagirdar AK Haque PT Cagle R Barrios Molecular Pathology of Lung Diseases 2008 Springer New York, NY
22. KJ Welsh, SA Risin, JK Actor, RL Hunter Immunopathology of postprimary tuberculosis: increased T-regulatory cells and DEC-205-positive foamy macrophages in cavitary lesions Clin Dev Immunol 2011 2011 307631
23. RL Hunter, C Jagannath, JK Actor Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs Tuberculosis (Edinb) 87 2007 267 278
24. RL Hunter On the pathogenesis of post primary tuberculosis: the role of bronchial obstruction in the pathogenesis of cavities Tuberculosis (Edinb) 91 Suppl 1 2011 S6 10
25. C Paige, WR Bishai Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view Cell Microbiol 12 2010 301 309
26. LY Armitige, C Jagannath, AR Wanger, SJ Norris Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages Infect Immun 68 2000 767 778
27. V Rao, N Fujiwara, SA Porcelli, MS Glickman Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule J Exp Med 201 2005 535 543
28. J Indrigo, RL Hunter Jr., JK Actor Cord factor trehalose 6,6′-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages Microbiology 149 2003 2049 2059
29. BJ Spargo, LM Crowe, T Ioneda, BL Beaman, JH Crowe Cord factor (alpha, alpha-trehalose 6,6′-dimycolate) inhibits fusion between phospholipid vesicles Proc Natl Acad Sci U S A 88 1991 737 740
30. J Indrigo, RL Hunter Jr., JK Actor Influence of trehalose 6,6′-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages Microbiology 148 2002 1991 1998
31. S Axelrod, H Oschkinat, J Enders, B Schlegel, V Brinkmann, SH Kaufmann, A Haas, UE Schaible Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide Cell Microbiol 10 2008 1530 1545
32. MK Katti, G Dai, LY Armitige, C Rivera Marrero, S Daniel, CR Singh, DR Lindsey, S Dhandayuthapani, RL Hunter, C Jagannath The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells Cell Microbiol 10 2008 1286 1303
33. CL Silva, SM Ekizlerian, RA Fazioli Role of cord factor in the modulation of infection caused by mycobacteria Am J Pathol 118 1985 238 247
34. C Kan-Sutton, C Jagannath, RL Hunter Jr. Trehalose 6,6′-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages Microbes Infect 11 2009 40 48
35. DN Dao, K Sweeney, T Hsu, SS Gurcha, IP Nascimento, D Roshevsky, GS Besra, J Chan, SA Porcelli, WR Jacobs Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production PLoS pathogens 4 2008 e1000081
36. G Trinchieri Interleukin-12 and its role in the generation of TH1 cells Immunol Today 14 1993 335 338
37. A O'Garra, K Murphy Role of cytokines in determining T-lymphocyte function Curr Opin Immunol 6 1994 458 466
38. K Sakamoto, MJ Kim, ER Rhoades, RE Allavena, S Ehrt, HC Wainwright, DG Russell, KH Rohde Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases Infect Immun 81 2013 764 776
39. CM Roche, A Smith, DR Lindsey, A Meher, K Schluns, A Arora, LY Armitige, C Jagannath The ΔfbpA attenuated candidate vaccine from Mycobacterium tuberculosis, H37Rv primes for a stronger T-bet dependent Th1 immunity in mice Tuberculosis (Edinb) 91 Suppl 1 2011 S96 104
40. RH Copenhaver, E Sepulveda, LY Armitige, JK Actor, A Wanger, SJ Norris, RL Hunter, C Jagannath A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential Infect Immun 72 2004 7084 7095
41. T Baba, Y Natsuhara, K Kaneda, I Yano Granuloma formation activity and mycolic acid composition of mycobacterial cord factor Cell Mol Life Sci 53 1997 227 232
42. Y Fujita, T Naka, T Doi, I Yano Direct molecular mass determination of trehalose monomycolate from 11 species of mycobacteria by MALDI-TOF mass spectrometry Microbiology 151 2005 1443 1452
43. R Ryll, Y Kumazawa, I Yano Immunological properties of trehalose dimycolate (cord factor) and other mycolic acid-containing glycolipids-a review Microbiol Immunol 45 2001 801 811
44. RL Perez, J Roman, S Roser, C Little, M Olsen, J Indrigo, RL Hunter, JK Actor Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6,6′- dimycolate J Interferon Cytokine Res 20 2000 795 804
45. KJ Welsh, AN Abbott, SA Hwang, J Indrigo, LY Armitige, MR Blackburn, RL Hunter Jr., JK Actor A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6′-dimycolate induced granulomatous response Microbiology 154 2008 1813 1824
46. CA Behling, RL Perez, MR Kidd, GW Staton Jr., RL Hunter Induction of pulmonary granulomas, macrophage procoagulant activity, and tumor necrosis factor-alpha by trehalose glycolipids Ann Clin Lab Sci 23 1993 256 266
47. Y Sakai, K Uchida, H Nakayama Histopathological features and expression profiles of cytokines, chemokines and SOCS family proteins in trehalose 6,6′-dimycolate-induced granulomatous lesions Inflamm Res 60 2011 371 378
48. AN Abbott, TV Guidry, KJ Welsh, AM Thomas, MA Kling, RL Hunter, JK Actor 11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6′- dimycolate Neuroimmunomodulation 16 2009 147 154
49. CW Borders, A Courtney, K Ronen, M Pilar Laborde-Lahoz, TV Guidry, SA Hwang, M Olsen, RL Hunter Jr., TJ Hollmann, RA Wetsel, JK Actor Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate Scand J Immunol 62 2005 123 130
50. H Takimoto, H Maruyama, KI Shimada, R Yakabe, I Yano, Y Kumazawa Interferon-gamma independent formation of pulmonary granuloma in mice by injections with trehalose dimycolate (cord factor), lipoarabinomannan and phosphatidylinositol mannosides isolated from Mycobacterium tuberculosis Clin Exp Immunol 144 2006 134 141
51. TV Guidry, RL Hunter Jr., JK Actor CD3+ cells transfer the hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate in mice Microbiology 152 2006 3765 3775
52. TV Guidry, RL Hunter Jr., JK Actor Mycobacterial glycolipid trehalose 6,6′-dimycolate-induced hypersensitive granulomas: contribution of CD4+ lymphocytes Microbiology 153 2007 3360 3369
53. A Bekierkunst, E Yarkoni Granulomatous hypersensitivity to trehalose-6,6′-dimycolate (cord factor) in mice infected with BCG Infect Immun 7 1973 631 638
54. H Yamagami, T Matsumoto, N Fujiwara, T Arakawa, K Kaneda, I Yano, K Kobayashi Trehalose 6,6′-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in mice Infect Immun 69 2001 810 815
55. A Tabata, K Kaneda, H Watanabe, T Abo, I Yano Kinetics of organ-associated natural killer cells and intermediate CD3 cells during pulmonary and hepatic granulomatous inflammation induced by mycobacterial cord factor Microbiol Immunol 40 1996 651 658
56. R Oiso, N Fujiwara, H Yamagami, S Maeda, S Matsumoto, S Nakamura, N Oshitani, T Matsumoto, T Arakawa, K Kobayashi Mycobacterial trehalose 6,6′-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein Microb Pathog 39 2005 35 43
57. I Matsunaga, M Sugita Lipid-specific immune responses against tuberculosis: from basic science to medical application Curr Immunol Rev 3 2007 145 150
58. R Ryll, K Watanabe, N Fujiwara, H Takimoto, R Hasunuma, Y Kumazawa, M Okada, I Yano Mycobacterial cord factor, but not sulfolipid, causes depletion of NKT cells and upregulation of CD1d1 on murine macrophages Microbes Infect 3 2001 611 619
59. JK Actor, M Olsen, RL Hunter Jr., YJ Geng Dysregulated response to mycobacterial cord factor trehalose-6,6′-dimycolate in CD1D-/- mice J Interferon Cytokine Res 21 2001 1089 1096
60. TV Guidry, M Olsen, KS Kil, RL Hunter Jr., YJ Geng, JK Actor Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6′-dimycolate J Interferon Cytokine Res 24 2004 362 371
61. DG Russell Who puts the tubercle in tuberculosis? Nat Rev Microbiol 5 2007 39 47
62. BM Saunders, AM Cooper Restraining mycobacteria: role of granulomas in mycobacterial infections Immunol Cell Biol 78 2000 334 341
63. GJ Churchyard, G Kaplan, D Fallows, RS Wallis, P Onyebujoh, GA Rook Advances in immunotherapy for tuberculosis treatment Clin Chest Med 30 2009 769 782 ix.
64. LG Wayne, CD Sohaskey Nonreplicating persistence of mycobacterium tuberculosis Annu Rev Microbiol 55 2001 139 163
65. E Roy, DB Lowrie, SR Jolles Current strategies in TB immunotherapy Curr Mol Med 7 2007 373 386
66. N Agarwal, G Lamichhane, R Gupta, S Nolan, WR Bishai Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase Nature 460 2009 98 102
67. H Bloch Studies on the virulence of tubercle bacilli: Isolation and biological properties of a constituent of virulent organisms J Exp Med 91 1950 197 219
68. J Seggev, MB Goren, RI Carr, CH Kirkpatrick Interstitial and hemorrhagic pneumonitis induced by mycobacterial trehalose dimycolate Am J Path 106 1982 348 355
69. JS Seggev, MB Goren, RI Carr, E Rubenstein, CH Kirkpatrick Pathogenesis of trehalose dimycolate-induced interstitial pneumonitis. IV. Evidence against roles for immunoglobulins and the complement system Exp Lung Res 14 1988 431 444
70. JS Seggev, MB Goren, CH Kirkpatrick The pathogenesis of trehalose dimycolate-induced interstitial pneumonitis. III. Evidence for a role for T lymphocytes Cellular immunology 85 1984 428 435
71. JS Seggev, CH Kirkpatrick, MB Goren The pathogenesis of interstitial pneumonitis induced by trehalose dimycolate. II. Reserpine prevents formation of lesions Am Rev Respir Dis 129 1984 840 843
72. E Yarkoni, HJ Rapp Influence of surfactant concentration on the antitumor activity of emulsified components of mycobacteria Cancer Res 40 1980 975 978
73. RE Geisel, K Sakamoto, DG Russell, ER Rhoades In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates J Immunol 174 2005 5007 5015
74. GS Retzinger Dissemination of beads coated with trehalose 6,6′-dimycolate: A possible role for coagulation in the dissemination process Exp Molec Pathol 46 1987 190 198
75. RW Schabbing, A Garcia, RL Hunter Characterization of the trehalose 6,6′-dimycolate surface monolayer by scanning tunneling microscopy Infect Immun 62 1994 754 756
76. CA Behling, B Bennett, K Takayama, RL Hunter Development of a trehalose 6,6′-dimycolate model which explains cord formation by Mycobacterium tuberculosis Infect Immun 61 1993 2296 2303
77. K Sakamoto, RE Geisel, MJ Kim, BT Wyatt, LB Sellers, ST Smiley, AM Cooper, DG Russell, ER Rhoades Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection Infect Immun 78 2010 1004 1011
78. Y Sakamoto, MB Goren, CH Kirkpatrick Phenotypes of infiltrating cells in trehalose dimycolate-induced interstitial pneumonitis Infect Immun 57 1989 2098 2106
79. DM Bowdish, K Sakamoto, MJ Kim, M Kroos, S Mukhopadhyay, CA Leifer, K Tryggvason, S Gordon, DG Russell MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis PLoS Pathogens 5 2009 e1000474
80. E Ishikawa, T Ishikawa, YS Morita, K Toyonaga, H Yamada, O Takeuchi, T Kinoshita, S Akira, Y Yoshikai, S Yamasaki Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle J Exp Med 206 2009 2879 2888
81. H Schoenen, B Bodendorfer, K Hitchens, S Manzanero, K Werninghaus, F Nimmerjahn, EM Agger, S Stenger, P Andersen, J Ruland, GD Brown, C Wells, R Lang Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate J Immunol 184 2010 2756 2760
82. K Werninghaus, A Babiak, O Gross, C Holscher, H Dietrich, EM Agger, J Mages, A Mocsai, H Schoenen, K Finger, F Nimmerjahn, GD Brown, C Kirschning, A Heit, P Andersen, H Wagner, J Ruland, R Lang Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation J Exp Med 206 2009 89 97
83. F Behler, K Steinwede, L Balboa, B Ueberberg, R Maus, G Kirchhof, S Yamasaki, T Welte, UA Maus Role of Mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice J Immunol 189 2012 3121 3129
84. L Heitmann, H Schoenen, S Ehlers, R Lang, C Holscher Mincle is not essential for controlling Mycobacterium tuberculosis infection Immunobiology 218 2013 506 516
85. Y Miyake, K Toyonaga, D Mori, S Kakuta, Y Hoshino, A Oyamada, H Yamada, KI Ono, M Suyama, Y Iwakura, Y Yoshikai, S Yamasaki C-type Lectin MCL Is an FcRgamma-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor Immunity 38 2013 1050 1062
86. D Carletti, DM da Fonseca, AF Gembre, AP Masson, LW Campos, LC Leite, AR Pires, J Lannes-Vieira, CL Silva, VL Bonato, C Horn A single dose of a DNA vaccine encoding Apa co-encapsulated with 6,6′ -trehalose dimycolate in microspheres conferred long-term protection against tuberculosis in BCG-primed mice Clin Vaccine Immunol 20 2013 1162 1169
87. I Azuma, T Seya Development of immunoadjuvants for immunotherapy of cancer Int Immunopharmacol 1 2001 1249 1259
88. RL Hunter Pathology of post primary tuberculosis of the lung: an illustrated critical review Tuberculosis (Edinb) 91 2011 497 509
89. RL Hunter On the pathogenesis of post primary tuberculosis: The role of bronchial obstruction in the pathogenesis of cavities Tuberculosis (Edinb) 91 Suppl 1 2011 S6 S10
90. J Coon, RL Hunter Selective induction of delayed type hypersensitivity by a lipid-conjugated protein antigen which is localized in thymus dependent lymphoid tissue J Immunol 110 1973 183 190
91. SS Syed, RL Hunter Jr. Studies on the toxic effects of quartz and a mycobacterial glycolipid, trehalose 6,6′-dimycolate Ann Clin Lab Sci 27 1997 375 383
92. A Dannenberg Tuberculosis and nontuberculosis mycobacterial infections D Schlossberg Pathophysiology: basic aspects 1999 W. B. Saunders Philadelphia 26 27
93. A Rich The pathogenesis of tuberculosis 1951 Charles C. Thomas Sringfield
94. ER Rhoades, RE Geisel, BA Butcher, S McDonough, DG Russell Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components Tuberculosis (Edinb) 85 2005 159 176
95. RL Hunter, L Armitige, C Jagannath, JK Actor TB research at UT-Houston-a review of cord factor: new approaches to drugs, vaccines and the pathogenesis of tuberculosis Tuberculosis (Edinb) 89 Suppl 1 2009 S18 S25
96. JK Actor Mycobacterial TDM: A Coat to Modulate Post Primary Pathogenesis? Mycobacterial Diseases 2 2012 e106
97. W Pagel, W Pagel Zur Histochemie der Lungentuberkulose, mit besonderer Berucksichtung der Fettsubstanzen und Lipoide. (Fat and lipoid content to tuberculous tissue. Histochemical investigation.) Virchows Arch path Anat 256 1925 629 640
98. Brennan PJ, Brigl M, Brenner MB. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol;13:101-17.