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These authors report that colonization of a murine host with symbiotic non-toxigenic Bacteroides fragilis can limit acquisition of pathogenic enterotoxigenic B. fragilis and prevent intestinal inflammatory disease.
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58 Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermudez-Humaran, L.G., Gratadoux, J.J., Blugeon, S., Bridonneau, C., Furet, J.P., Corthier, G., et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 105 (2008), 16731–16736.
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These authors gain insights to mechanisms underlying beneficial effects using a novel gnotobiotic diassociation rodent model in which E. coli primed the gastrointestinal tract allowing a stable establishment of the extreme oxygen-sensitive F. prausnitzii. Metabolic profiling along the GI tract and in the peripheral blood identified signature metabolites linked to anti-inflammatory effects.
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59•• Miquel, S., Leclerc, M., Martin, R., Chain, F., Lenoir, M., Raguideau, S., Hudault, S., Bridonneau, C., Northen, T., Bowen, B., et al. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii. MBio, 6, 2015 These authors gain insights to mechanisms underlying beneficial effects using a novel gnotobiotic diassociation rodent model in which E. coli primed the gastrointestinal tract allowing a stable establishment of the extreme oxygen-sensitive F. prausnitzii. Metabolic profiling along the GI tract and in the peripheral blood identified signature metabolites linked to anti-inflammatory effects.
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