Genetic variants in the Vitamin D pathway, 25(OH)D Levels, and mortality in a large population-based cohort study

Journal of Clinical Endocrinology and Metabolism

Volumn 102, Issue 2, 2017, Pages 470-477

  Ordoñez Mena, Jose Manuel ^a,b,c   Maalmi, Haifa ^a,b   Schottker, Ben ^a,b   Saum, Kai Uwe ^a   Holleczek, Bernd ^d   Wang, Thomas J ^e   Burwinkel, Barbara ^a,b   Brenner, Hermann ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d SAARLAND CANCER REGISTRY   (Germany)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL 24 HYDROXYLASE; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGED; ALLELE; CAUSE OF DEATH; COHORT ANALYSIS; CONTROLLED STUDY; CYP24A1 GENE; CYP2R1 GENE; DHCR7 GENE; FEMALE; GC GENE; GENE; GENETIC VARIABILITY; GENOTYPE; GERMANIC PEOPLE; HUMAN; MALE; MORTALITY; POPULATION RESEARCH; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; VDR GENE; ANALOGS AND DERIVATIVES; BLOOD; EPIDEMIOLOGY; EXERCISE; GENETIC PREDISPOSITION; GENETICS; GERMANY; MIDDLE AGED; PHYSIOLOGY; SIGNAL TRANSDUCTION; VITAMIN D DEFICIENCY;

AGED; ALLELES; EXERCISE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 85012066532     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-2468     Document Type: Review

References (32)

1. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: A meta-analysis of prospective cohort studies. Am J Clin Nutr. 2012;95(1):91-100.
2. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: A systematic review. Lancet Diabetes Endocrinol. 2014; 2(1):76-89.
3. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: Lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726-776.
4. Querfeld U. Vitamin D and inflammation. Pediatr Nephrol. 2013; 28(4):605-610.
5. Fleet JC, DeSmet M, Johnson R, Li Y. Vitamin D and cancer: A review of molecular mechanisms. Biochem J. 2012;441(1):61-76.
6. Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: Systematic review of clinical studies. J Steroid Biochem Mol Biol. 2013;136:321-329.
7. Afzal S, Nordestgaard BG. Low vitamin D and hypertension: A causal association?. Lancet Diabetes Endocrinol. 2014;2(9): 682-684.
8. Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, Njølstad I, Løchen ML, Figenschau Y, Berg JP, Svartberg J, Grimnes G. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study. PLoS One. 2012;7(5):e37295.
9. Trummer O, Pilz S, Hoffmann MM,Winkelmann BR, Boehm BO, März W, Pieber TR, Obermayer-Pietsch B, Renner W. Vitamin D and mortality: A Mendelian randomization study. Clin Chem. 2013;59(5):793-797.
10. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ. 2014;349:g6330.
11. de Jongh RT, Lips P, Rijs KJ, van Schoor NM, Kramer MH, Vandenbroucke JP, Dekkers OM. Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals. Eur J Endocrinol. 2011;164(1):75-82.
12. Levin GP, Robinson-Cohen C, de Boer IH, Houston DK, Lohman K, Liu Y, Kritchevsky SB, Cauley JA, Tanaka T, Ferrucci L, Bandinelli S, Patel KV, Hagström E, Michäelsson K, Melhus H, Wang T, Wolf M, Psaty BM, Siscovick D, Kestenbaum B. Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA. 2012;308(18):1898-1905.
13. Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RG, van Heemst D. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging. 2009;30(3): 466-473.
14. Schöttker B, Haug U, Schomburg L, Köhrle J, Perna L, Müller H, Holleczek B, Brenner H. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr. 2013;97(4):782-793.
15. RaumE,RothenbacherD, LöwM, StegmaierC,ZieglerH, Brenner H. Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: A life course approach. Eur J Cardiovasc Prev Rehabil. 2007;14(6):809-814.
16. Schöttker B, Jansen EH, Haug U, Schomburg L, Köhrle J, Brenner H. Standardization ofmisleading immunoassay based 25-hydroxyvitamin D levels with liquid chromatography tandem-mass spectrometry in a large cohort study. PLoS One. 2012;7(11):e48774.
17. Perna L, Haug U, Schöttker B, Müller H, Raum E, Jansen EH, Brenner H. Public health implications of standardized 25-hydroxyvitamin D levels: A decrease in the prevalence of vitamin D deficiency among older women in Germany. Prev Med. 2012;55(3):228-232.
18. Zerwekh JE. Blood biomarkers of vitaminDstatus.AmJ Clin Nutr. 2008;87(4): 1087S-1091S.
19. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Jarvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD. Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet. 2010;376(9736):180-188.
20. Wang Y, Jacobs EJ, McCullough ML, Rodriguez C, Thun MJ, Calle EE, Flanders WD. Comparing methods for accounting for seasonal variability in a biomarker when only a single sample is available: Insights from simulations based on serum 25-hydroxyvitamin d. Am J Epidemiol. 2009;170(1):88-94.
21. WHO Scientific Group on Prevention and Management of Osteoporosis. Prevention and management of osteoporosis: Report of a WHO scientific group. Geneva, Switzerland: WHO; 2003:921.
22. Schöttker B, Ball D, Gellert C, Brenner H. Serum 25-hydroxyvitamin D levels and overall mortality. A systematic review and meta-analysis of prospective cohort studies. Ageing Res Rev. 2013; 12(2):708-718.
23. Schöttker B, Jorde R, Peasey A, Thorand B, Jansen EH, Groot Ld, StreppelM, Gardiner J, Ordóñez-Mena JM, Perna L,Wilsgaard T, Rathmann W, Feskens E, Kampman E, Siganos G, Njølstad I, Mathiesen EB, Kubínová R, Pająk A, Topor-Madry R, Tamosiunas A, Hughes M, Kee F, Bobak M, Trichopoulou A, Boffetta P, Brenner H; Consortiumon Health and Ageing: Network of Cohorts in Europe and the United States. Vitamin D and mortality: Metaanalysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ. 2014;348: G3656.
24. Burns PB, Rohrich RJ, Chung KC. The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg. 2011;128(1): 305-310.
25. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: Umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014;348:g2035.
26. Guessous I. Role of vitamin D deficiency in extraskeletal complications: Predictor of health outcome or marker of health status?. Biomed Res Int. 2015;2015:563403.
27. Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Wetterslev J, Simonetti RG, Bjelakovic M, Gluud C. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2014;1(1):CD007470.
28. Brøndum-Jacobsen P, Benn M, Afzal S, Nordestgaard BG. No evidence that genetically reduced 25-hydroxyvitamin D is associated with increased risk of ischaemic heart disease or myocardial infarction: A Mendelian randomization study. Int J Epidemiol. 2015;44(2):651-661.
29. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, Jacobs KB, Li Q, Weinstein SJ, Purdue M, Virtamo J, Horst R, Wheeler W, Chanock S, Hunter DJ, Hayes RB, Kraft P, Albanes D. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet. 2010;19(13):2739-2745.
30. Bu FX, Armas L, Lappe J, Zhou Y, Gao G, Wang HW, Recker R, Zhao LJ. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet. 2010;128(5):549-556.
31. Yang B, Lu C, Wu Q, Zhang J, Zhao H, Cao Y. Parathyroid hormone, cardiovascular and all-cause mortality: A meta-analysis. Clin Chim Acta. 2016;455:154-160.
32. van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA. Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies. Am Heart J. 2013;165(5): 655-664, 664.e1-5.