메뉴 건너뛰기




Volumn 75, Issue , 2017, Pages 157-165

Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

Author keywords

Cannabidiol; Dopamine; Pharmacotherapy; Post traumatic stress disorder; Schizophrenia

Indexed keywords

CANNABIDIOL; DOPAMINE; HALOPERIDOL; NEUROLEPTIC AGENT; SEROTONIN 5A RECEPTOR; DRONABINOL;

EID: 85012066454     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2017.02.006     Document Type: Review
Times cited : (84)

References (79)
  • 1
    • 26844572307 scopus 로고    scopus 로고
    • The effects of antipsychotics on B-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats
    • Alimohamad, H., Sutton, L., Mouyal, J., Rajakumar, N., Rushlow, W.J., The effects of antipsychotics on B-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats. J. Neurochem. 95 (2005), 513–525.
    • (2005) J. Neurochem. , vol.95 , pp. 513-525
    • Alimohamad, H.1    Sutton, L.2    Mouyal, J.3    Rajakumar, N.4    Rushlow, W.J.5
  • 2
    • 0000735519 scopus 로고
    • Cannabis and schizophrenia: a longitudinal study of Swedish conscripts
    • Andréasson, S., Allebeck, P., Engström, A., Rydberg, U., Cannabis and schizophrenia: a longitudinal study of Swedish conscripts. Lancet 26 (1987), 1483–1486.
    • (1987) Lancet , vol.26 , pp. 1483-1486
    • Andréasson, S.1    Allebeck, P.2    Engström, A.3    Rydberg, U.4
  • 3
    • 0035862960 scopus 로고    scopus 로고
    • Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes
    • Asad Khan, A., Antonio, M., Pepio, A.M., Sossin, W.S., Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes. J. Neurosci. 21:2 (2001), 382–391.
    • (2001) J. Neurosci. , vol.21 , Issue.2 , pp. 382-391
    • Asad Khan, A.1    Antonio, M.2    Pepio, A.M.3    Sossin, W.S.4
  • 4
    • 10044247109 scopus 로고    scopus 로고
    • Impact of atypical antipsychotics on quality of life in patients with schizophrenia
    • Awad, A.G., Voruganti, L.N.P., Impact of atypical antipsychotics on quality of life in patients with schizophrenia. CNS Drugs 18 (2004), 877–893.
    • (2004) CNS Drugs , vol.18 , pp. 877-893
    • Awad, A.G.1    Voruganti, L.N.P.2
  • 8
    • 84870053882 scopus 로고    scopus 로고
    • Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of δ-9-tetrahydrocannabinol on midbrain and striatal function
    • Bhattacharyya, S., Atakan, Z., Martin-Santos, R., Crippa, J.A., Kambeitz, J., Prata, D., Williams, S., Brammer, M., Collier, D.A., McGuire, P.K., Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of δ-9-tetrahydrocannabinol on midbrain and striatal function. Mol. Psychiatry 17 (2012), 1152–1155.
    • (2012) Mol. Psychiatry , vol.17 , pp. 1152-1155
    • Bhattacharyya, S.1    Atakan, Z.2    Martin-Santos, R.3    Crippa, J.A.4    Kambeitz, J.5    Prata, D.6    Williams, S.7    Brammer, M.8    Collier, D.A.9    McGuire, P.K.10
  • 9
    • 0018091004 scopus 로고
    • The effects of cannabinoids on body temperature and brain catecholamine synthesis
    • Bloom, A.S., Johnson, K.M., Dewey, W.L., The effects of cannabinoids on body temperature and brain catecholamine synthesis. Res. Commun. Chem. Pathol. Pharmacol. 20 (1978), 51–57.
    • (1978) Res. Commun. Chem. Pathol. Pharmacol. , vol.20 , pp. 51-57
    • Bloom, A.S.1    Johnson, K.M.2    Dewey, W.L.3
  • 10
    • 84900854828 scopus 로고    scopus 로고
    • The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study
    • Bloomfield, M.A., Morgan, C.J., Kapur, S., Curran, H.V., Howes, O.D., The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study. Psychopharmacology 231 (2014), 2251–2259.
    • (2014) Psychopharmacology , vol.231 , pp. 2251-2259
    • Bloomfield, M.A.1    Morgan, C.J.2    Kapur, S.3    Curran, H.V.4    Howes, O.D.5
  • 11
    • 84894479797 scopus 로고    scopus 로고
    • Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms
    • Bloomfield, M.A., Morgan, C.J., Egerton, A., Kapur, S., Curran, H.V., Howes, O.D., Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms. Biol. Psychiatry 75 (2014), 470–478.
    • (2014) Biol. Psychiatry , vol.75 , pp. 470-478
    • Bloomfield, M.A.1    Morgan, C.J.2    Egerton, A.3    Kapur, S.4    Curran, H.V.5    Howes, O.D.6
  • 12
    • 77955992306 scopus 로고    scopus 로고
    • Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia
    • Bossong, M.G., Niesink, J.M., Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia. Prog. Neurobiol. 92 (2010), 370–385.
    • (2010) Prog. Neurobiol. , vol.92 , pp. 370-385
    • Bossong, M.G.1    Niesink, J.M.2
  • 13
    • 84937733693 scopus 로고    scopus 로고
    • Further human evidence for striatal dopamine release induced by administration of Δ9-tetrahydrocannabinol (THC): selectivity to limbic striatum
    • Bossong, M.G., Mehta, M.A., van Berckel, B.N., Howes, O.D., Kahn, R.S., Stokes, P.R., Further human evidence for striatal dopamine release induced by administration of Δ9-tetrahydrocannabinol (THC): selectivity to limbic striatum. Psychopharmacology 232 (2015), 2723–2729.
    • (2015) Psychopharmacology , vol.232 , pp. 2723-2729
    • Bossong, M.G.1    Mehta, M.A.2    van Berckel, B.N.3    Howes, O.D.4    Kahn, R.S.5    Stokes, P.R.6
  • 14
    • 84966738329 scopus 로고    scopus 로고
    • Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression
    • Bruijnzeel, D., Tandon, R., Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression. Drug Des. Dev. Ther. 10 (2016), 1641–1647.
    • (2016) Drug Des. Dev. Ther. , vol.10 , pp. 1641-1647
    • Bruijnzeel, D.1    Tandon, R.2
  • 16
    • 84887039245 scopus 로고    scopus 로고
    • Cannabis use during adolescent development: susceptibility to psychiatric illness
    • Chadwick, B., Miller, M.L., Hurd, Y.L., Cannabis use during adolescent development: susceptibility to psychiatric illness. Front Psychiatry, 4, 2013, 129.
    • (2013) Front Psychiatry , vol.4 , pp. 129
    • Chadwick, B.1    Miller, M.L.2    Hurd, Y.L.3
  • 17
    • 2342668029 scopus 로고    scopus 로고
    • Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats
    • Cheer, J.F., Wassum, K.M., Heien, M.L., Phillips, P.E., Wightman, R.M., Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J. Neurosci. 24 (2004), 4393–4400.
    • (2004) J. Neurosci. , vol.24 , pp. 4393-4400
    • Cheer, J.F.1    Wassum, K.M.2    Heien, M.L.3    Phillips, P.E.4    Wightman, R.M.5
  • 18
    • 84938677047 scopus 로고    scopus 로고
    • Brexpiprazole: a new dopamine D₂receptor partial agonist for the treatment of schizophrenia and major depressive disorder
    • Citrome, L., Brexpiprazole: a new dopamine D₂receptor partial agonist for the treatment of schizophrenia and major depressive disorder. Drugs Today (Barc) 51 (2015), 397–414.
    • (2015) Drugs Today (Barc) , vol.51 , pp. 397-414
    • Citrome, L.1
  • 21
    • 79958818048 scopus 로고    scopus 로고
    • Paranoid schizophrenia is characterized by increased CB1 receptor binding in the dorsolateral prefrontal cortex
    • Dalton, V.S., Long, L.E., Weickert, C.S., Zavitsanou, K., Paranoid schizophrenia is characterized by increased CB1 receptor binding in the dorsolateral prefrontal cortex. Neuropsychopharmacology 36 (2011), 1620–1630.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1620-1630
    • Dalton, V.S.1    Long, L.E.2    Weickert, C.S.3    Zavitsanou, K.4
  • 22
    • 0035961131 scopus 로고    scopus 로고
    • Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
    • Dean, B., Sundram, S., Bradbury, R., Scarr, E., Copolov, D., Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use. Neuroscience 103 (2001), 9–15.
    • (2001) Neuroscience , vol.103 , pp. 9-15
    • Dean, B.1    Sundram, S.2    Bradbury, R.3    Scarr, E.4    Copolov, D.5
  • 24
    • 84923298138 scopus 로고    scopus 로고
    • Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study
    • Di Forti, M., Marconi, A., Carra, E., Fraietta, S., Trotta, A., et al. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study. Lancet Psychiatry 2 (2015), 233–238.
    • (2015) Lancet Psychiatry , vol.2 , pp. 233-238
    • Di Forti, M.1    Marconi, A.2    Carra, E.3    Fraietta, S.4    Trotta, A.5
  • 25
    • 84856356408 scopus 로고    scopus 로고
    • Rat models of prenatal and adolescent cannabis exposure
    • Dinieri, J.A., Hurd, Y.L., Rat models of prenatal and adolescent cannabis exposure. Methods Mol. Biol. 829 (2012), 231–242.
    • (2012) Methods Mol. Biol. , vol.829 , pp. 231-242
    • Dinieri, J.A.1    Hurd, Y.L.2
  • 26
    • 84907294899 scopus 로고    scopus 로고
    • Cannabinoid transmission in the prefrontal cortex Bi-phasically controls emotional memory formation via functional interactions with the ventral tegmental area
    • Draycott, B., Loureiro, M., Ahmad, T., Tan, H., Zunder, J., Laviolette, S.R., Cannabinoid transmission in the prefrontal cortex Bi-phasically controls emotional memory formation via functional interactions with the ventral tegmental area. J. Neurosci. 34 (2014), 13096–13109.
    • (2014) J. Neurosci. , vol.34 , pp. 13096-13109
    • Draycott, B.1    Loureiro, M.2    Ahmad, T.3    Tan, H.4    Zunder, J.5    Laviolette, S.R.6
  • 27
    • 84859348838 scopus 로고    scopus 로고
    • AKT/GSK3 signaling pathway and schizophrenia
    • Emamian, E.S., AKT/GSK3 signaling pathway and schizophrenia. Front. Mol. Neurosci., 15(5), 2012, 33.
    • (2012) Front. Mol. Neurosci. , vol.15 , Issue.5 , pp. 33
    • Emamian, E.S.1
  • 29
    • 77950598371 scopus 로고    scopus 로고
    • Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action
    • Freyberg, Z., Ferrando, S.J., Javitch, J.A., Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am. J. Psychiatry 167 (2010), 388–396.
    • (2010) Am. J. Psychiatry , vol.167 , pp. 388-396
    • Freyberg, Z.1    Ferrando, S.J.2    Javitch, J.A.3
  • 30
    • 65849530958 scopus 로고    scopus 로고
    • 5-HT 1A and 5-HT 1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats
    • Fujita, S., Kiguchi, M., Lee, J., Terakado, M., Suga, K., Hatanaka, H., Koshikawa, N., 5-HT 1A and 5-HT 1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats. J. Oral Sci. 50 (2008), 387–395.
    • (2008) J. Oral Sci. , vol.50 , pp. 387-395
    • Fujita, S.1    Kiguchi, M.2    Lee, J.3    Terakado, M.4    Suga, K.5    Hatanaka, H.6    Koshikawa, N.7
  • 31
    • 2442641276 scopus 로고    scopus 로고
    • Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum
    • Guimarães, V.M., Zuardi, A.W., Del Bel, E.A., Guimarães, F.S., Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sci. 75 (2004), 633–638.
    • (2004) Life Sci. , vol.75 , pp. 633-638
    • Guimarães, V.M.1    Zuardi, A.W.2    Del Bel, E.A.3    Guimarães, F.S.4
  • 32
    • 84898949603 scopus 로고    scopus 로고
    • Is the mTOR-signalling cascade disrupted in schizophrenia?
    • Gururajan, A., Van Den Buuse, M., Is the mTOR-signalling cascade disrupted in schizophrenia?. J. Neurochem. 129 (2014), 377–387.
    • (2014) J. Neurochem. , vol.129 , pp. 377-387
    • Gururajan, A.1    Van Den Buuse, M.2
  • 33
    • 79955964765 scopus 로고    scopus 로고
    • Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia
    • Gururajan, A., Taylor, D.A., Malone, D.T., Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia. Behav. Brain Res. 222 (2011), 299–308.
    • (2011) Behav. Brain Res. , vol.222 , pp. 299-308
    • Gururajan, A.1    Taylor, D.A.2    Malone, D.T.3
  • 34
    • 72149097806 scopus 로고    scopus 로고
    • Home Office Cannabis Potency Study
    • Home Office U.K
    • Hardwick, S., King, L., Home Office Cannabis Potency Study. 2008, Home Office, U.K.
    • (2008)
    • Hardwick, S.1    King, L.2
  • 36
    • 0028788324 scopus 로고
    • 1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens
    • 1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. Eur. J. Pharmacol. 287 (1995), 179–184.
    • (1995) Eur. J. Pharmacol. , vol.287 , pp. 179-184
    • Ichikawa, J.1    Kuroki, T.2    Kitchen, M.T.3    Meltzer, H.Y.4
  • 39
    • 84874413463 scopus 로고    scopus 로고
    • Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus
    • Katsidoni, V., Anagnostou, I., Panagis, G., Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus. Addict. Biol. 18 (2013), 286–296.
    • (2013) Addict. Biol. , vol.18 , pp. 286-296
    • Katsidoni, V.1    Anagnostou, I.2    Panagis, G.3
  • 41
  • 42
    • 33747394810 scopus 로고    scopus 로고
    • The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    • Laviolette, S.R., Grace, A.A., The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. Cell. Mol. Life Sci. 63 (2006), 1597–1613.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 1597-1613
    • Laviolette, S.R.1    Grace, A.A.2
  • 45
    • 32044456989 scopus 로고    scopus 로고
    • Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1
    • Liu, Y., Fanburg, B.L., Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Am. J. Respir. Cell Mol. Biol. 34 (2006), 182–191.
    • (2006) Am. J. Respir. Cell Mol. Biol. , vol.34 , pp. 182-191
    • Liu, Y.1    Fanburg, B.L.2
  • 47
    • 33645029075 scopus 로고    scopus 로고
    • Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
    • Long, L.E., Malone, D.T., Taylor, D.A., Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology 31 (2006), 795–803.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 795-803
    • Long, L.E.1    Malone, D.T.2    Taylor, D.A.3
  • 48
    • 84860736918 scopus 로고    scopus 로고
    • Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort
    • Manrique-Garcia, E., Zammit, S., Dalman, C., Hemmingsson, T., Andreasson, S., Allebeck, P., Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort. Psychol. Med. 42 (2012), 1321–1328.
    • (2012) Psychol. Med. , vol.42 , pp. 1321-1328
    • Manrique-Garcia, E.1    Zammit, S.2    Dalman, C.3    Hemmingsson, T.4    Andreasson, S.5    Allebeck, P.6
  • 49
    • 55249091422 scopus 로고    scopus 로고
    • Schizophrenia: a concise overview of incidence, prevalence, and mortality
    • McGrath, J., Saha, S., Chant, D., Welham, J., Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol. Rev. 30 (2008), 67–76.
    • (2008) Epidemiol. Rev. , vol.30 , pp. 67-76
    • McGrath, J.1    Saha, S.2    Chant, D.3    Welham, J.4
  • 50
    • 84908555675 scopus 로고    scopus 로고
    • Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats
    • Mijangos-Moreno, S., Poot-Aké, A., Arankowsky-Sandoval, G., Murillo-Rodríguez, E., Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neurosci. Res. 84 (2014), 60–63.
    • (2014) Neurosci. Res. , vol.84 , pp. 60-63
    • Mijangos-Moreno, S.1    Poot-Aké, A.2    Arankowsky-Sandoval, G.3    Murillo-Rodríguez, E.4
  • 51
    • 17444393586 scopus 로고    scopus 로고
    • Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice
    • Moreira, F.A., Guimarães, F.S., Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice. Eur. J. Pharmacol. 512 (2005), 199–205.
    • (2005) Eur. J. Pharmacol. , vol.512 , pp. 199-205
    • Moreira, F.A.1    Guimarães, F.S.2
  • 53
    • 84964091075 scopus 로고    scopus 로고
    • AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers
    • Morgan, C.J., Freeman, T.P., Powell, J., Curran, H.V., AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers. Transl. Psychiatry, 16(February (6)), 2016, e738, 10.1038/tp.2015.219.
    • (2016) Transl. Psychiatry , vol.16 , Issue.February (6) , pp. e738
    • Morgan, C.J.1    Freeman, T.P.2    Powell, J.3    Curran, H.V.4
  • 54
    • 79952438369 scopus 로고    scopus 로고
    • Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats
    • Murillo-Rodríguez, E., Palomero-Rivero, M., Millán-Aldaco, D., Mechoulam, R., Drucker-Colín, R., Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats. Life Sci. 88 (2011), 504–511.
    • (2011) Life Sci. , vol.88 , pp. 504-511
    • Murillo-Rodríguez, E.1    Palomero-Rivero, M.2    Millán-Aldaco, D.3    Mechoulam, R.4    Drucker-Colín, R.5
  • 55
    • 84977098185 scopus 로고    scopus 로고
    • Cannabidiol modulates fear memory formation through interactions with serotonergic transmission in the mesolimbic system
    • Epub ahead of print
    • Norris, C., Loureiro, M., Kramar, C., Zunder, J., Renard, J., Rushlow, W., Laviolette, S.R., Cannabidiol modulates fear memory formation through interactions with serotonergic transmission in the mesolimbic system. Neuropsychopharmacology(June), 2016, 10.1038/npp.2016.93 Epub ahead of print.
    • (2016) Neuropsychopharmacology , Issue.June
    • Norris, C.1    Loureiro, M.2    Kramar, C.3    Zunder, J.4    Renard, J.5    Rushlow, W.6    Laviolette, S.R.7
  • 56
    • 84899541896 scopus 로고    scopus 로고
    • Amphetamine sensitization alters reward processing in the human striatum and amygdala
    • O'Daly, O.G., Joyce, D., Tracy, D.K., Azim, A., Stephan, K.E., Murray, R.M., Shergill, S.S., Amphetamine sensitization alters reward processing in the human striatum and amygdala. PLoS One, 9(April (4)), 2014, e93955.
    • (2014) PLoS One , vol.9 , Issue.April (4) , pp. e93955
    • O'Daly, O.G.1    Joyce, D.2    Tracy, D.K.3    Azim, A.4    Stephan, K.E.5    Murray, R.M.6    Shergill, S.S.7
  • 58
    • 33645502759 scopus 로고    scopus 로고
    • The pharmacology of cannabinoid receptors and their ligands: an overview
    • Pertwee, R.G., The pharmacology of cannabinoid receptors and their ligands: an overview. Int. J. Obes. 30 (2006), S13–S18.
    • (2006) Int. J. Obes. , vol.30 , pp. S13-S18
    • Pertwee, R.G.1
  • 59
    • 0018954391 scopus 로고
    • Effects of cannabinoids on catecholamine uptake and release in hypothalamic and striatal synaptosomes
    • Poddar, M.K., Dewey, W.L., Effects of cannabinoids on catecholamine uptake and release in hypothalamic and striatal synaptosomes. J. Pharmacol. Exp. Ther. 214 (1980), 63–67.
    • (1980) J. Pharmacol. Exp. Ther. , vol.214 , pp. 63-67
    • Poddar, M.K.1    Dewey, W.L.2
  • 61
    • 39049124647 scopus 로고    scopus 로고
    • Potency of D9–THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology
    • Potter, D.J., Clark, P., Brown, M.B., Potency of D9–THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. J. Forensic Sci. 53 (2008), 90–94.
    • (2008) J. Forensic Sci. , vol.53 , pp. 90-94
    • Potter, D.J.1    Clark, P.2    Brown, M.B.3
  • 62
    • 77955931468 scopus 로고    scopus 로고
    • Antipsychotic dosing: how much but also how often?
    • Remington, G., Kapur, S., Antipsychotic dosing: how much but also how often?. Schizophr. Bull. 36 (2010), 900–903.
    • (2010) Schizophr. Bull. , vol.36 , pp. 900-903
    • Remington, G.1    Kapur, S.2
  • 63
    • 84949117809 scopus 로고    scopus 로고
    • Long-term consequences of adolescent cannabinoid exposure in adult psychopathology
    • Renard, J., Krebs, M., Le, Pen G., Jay, T.M., Long-term consequences of adolescent cannabinoid exposure in adult psychopathology. Front. Neurosci. 8 (2014), 1–14.
    • (2014) Front. Neurosci. , vol.8 , pp. 1-14
    • Renard, J.1    Krebs, M.2    Le, P.G.3    Jay, T.M.4
  • 64
    • 84978708625 scopus 로고    scopus 로고
    • What can rats tell us about adolescent cannabis exposure? Insights from preclinical research
    • Renard, J., Rushlow, W.J., Laviolette, S.R., What can rats tell us about adolescent cannabis exposure? Insights from preclinical research. Can. J. Psychiatry 61 (2016), 328–334.
    • (2016) Can. J. Psychiatry , vol.61 , pp. 328-334
    • Renard, J.1    Rushlow, W.J.2    Laviolette, S.R.3
  • 65
    • 84978745776 scopus 로고    scopus 로고
    • Adolescent cannabinoid exposure induces a persistent sub-cortical hyper-dopaminergic state and associated molecular adaptations in the prefrontal cortex
    • E-Pub ahead of print
    • Renard, J., Rosen, L.G., Loueiro, M., De Oliveira, C., Schmid, S., Rushlow, W.J., Laviolette, S.R., Adolescent cannabinoid exposure induces a persistent sub-cortical hyper-dopaminergic state and associated molecular adaptations in the prefrontal cortex. Cereb. Cortex(January), 2016 E-Pub ahead of print.
    • (2016) Cereb. Cortex , Issue.January
    • Renard, J.1    Rosen, L.G.2    Loueiro, M.3    De Oliveira, C.4    Schmid, S.5    Rushlow, W.J.6    Laviolette, S.R.7
  • 66
    • 84965060438 scopus 로고    scopus 로고
    • Cannabidiol counteracts amphetamine-induced neuronal and behavioral sensitization of the mesolimbic dopamine pathway through a novel mTOR/p70S6 kinase signaling pathway
    • E-Pub ahead of print
    • Renard, J., Rosen, L.G., Loueiro, M., Zunder, J., De Oliveira, C., Schmid, S., Rushlow, W.J., Laviolette, S.R., Cannabidiol counteracts amphetamine-induced neuronal and behavioral sensitization of the mesolimbic dopamine pathway through a novel mTOR/p70S6 kinase signaling pathway. J. Neurosci., 4(May), 2016 E-Pub ahead of print.
    • (2016) J. Neurosci. , vol.4 , Issue.May
    • Renard, J.1    Rosen, L.G.2    Loueiro, M.3    Zunder, J.4    De Oliveira, C.5    Schmid, S.6    Rushlow, W.J.7    Laviolette, S.R.8
  • 67
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo, E.B., Burnett, A., Hall, B., Parker, K.K., Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem. Res. 30 (2005), 1037–1043.
    • (2005) Neurochem. Res. , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 68
    • 17744379225 scopus 로고    scopus 로고
    • Cannabis as a risk factor for psychosis: systematic review
    • Semple, D.M., Mcintosh, A.M., Lawrie, S.M., Cannabis as a risk factor for psychosis: systematic review. J. Psychopharm. 19 (2005), 187–194.
    • (2005) J. Psychopharm. , vol.19 , pp. 187-194
    • Semple, D.M.1    Mcintosh, A.M.2    Lawrie, S.M.3
  • 70
    • 1942502359 scopus 로고    scopus 로고
    • Cannabis use and the risk of later schizophrenia: a review
    • Smit, F., Bolier, L., Cuijpers, P., Cannabis use and the risk of later schizophrenia: a review. Addiction 99 (2004), 425–430.
    • (2004) Addiction , vol.99 , pp. 425-430
    • Smit, F.1    Bolier, L.2    Cuijpers, P.3
  • 71
    • 85071501246 scopus 로고    scopus 로고
    • High potency cannabis: the forgotten variable
    • Smith, N., High potency cannabis: the forgotten variable. Addiction 100 (2005), 1558–1559.
    • (2005) Addiction , vol.100 , pp. 1558-1559
    • Smith, N.1
  • 73
    • 34250179171 scopus 로고    scopus 로고
    • Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3
    • Sutton, L.P., Honardoust, D., Mouyal, J., Rajakumar, N., Rushlow, W.J., Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3. J. Neurochem. 102 (2007), 153–169.
    • (2007) J. Neurochem. , vol.102 , pp. 153-169
    • Sutton, L.P.1    Honardoust, D.2    Mouyal, J.3    Rajakumar, N.4    Rushlow, W.J.5
  • 74
    • 84988584541 scopus 로고    scopus 로고
    • Animal models of deficient sensorimotor gating in schizophrenia: are they still relevant?
    • Swerdlow, N.R., Light, G.A., Animal models of deficient sensorimotor gating in schizophrenia: are they still relevant?. Curr. Top. Behav. Neurosci.(June), 2016.
    • (2016) Curr. Top. Behav. Neurosci. , Issue.June
    • Swerdlow, N.R.1    Light, G.A.2
  • 75
    • 84904501557 scopus 로고    scopus 로고
    • The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia
    • Tan, H., Ahmad, T., Loureiro, M., Zunder, J., Laviolette, S.R., The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia. Front Psychiatry, 30(5), 2014, 73.
    • (2014) Front Psychiatry , vol.30 , Issue.5 , pp. 73
    • Tan, H.1    Ahmad, T.2    Loureiro, M.3    Zunder, J.4    Laviolette, S.R.5
  • 77
    • 0033622131 scopus 로고    scopus 로고
    • Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment
    • Wu, X., French, E.D., Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology 39 (2000), 391–398.
    • (2000) Neuropharmacology , vol.39 , pp. 391-398
    • Wu, X.1    French, E.D.2
  • 78
    • 0025876938 scopus 로고
    • Effects of cannabidiol in animal models predictive of antipsychotic activity
    • Zuardi, A.W., Antunes Rodrigues, J., Cunha, J.M., Effects of cannabidiol in animal models predictive of antipsychotic activity. Psychopharmacology (Berl.) 104 (1991), 260–264.
    • (1991) Psychopharmacology (Berl.) , vol.104 , pp. 260-264
    • Zuardi, A.W.1    Antunes Rodrigues, J.2    Cunha, J.M.3
  • 79
    • 79961076382 scopus 로고    scopus 로고
    • Is the highest density of CB1 receptors in paranoid schizophrenia a correlate of endocannabinoid system functioning?
    • Zuardi, A.W., Guimarães, F.S., Hallak, J.E., Crippa, J.A., Is the highest density of CB1 receptors in paranoid schizophrenia a correlate of endocannabinoid system functioning?. Expert Rev. Neurother. 11 (2011), 1111–1114.
    • (2011) Expert Rev. Neurother. , vol.11 , pp. 1111-1114
    • Zuardi, A.W.1    Guimarães, F.S.2    Hallak, J.E.3    Crippa, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.