메뉴 건너뛰기




Volumn 11, Issue 2, 2017, Pages 210-222

Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats

Author keywords

cardiotoxicity; echocardiography; Nanomaterials; polymer carriers; telemetry

Indexed keywords

CASPASE 3; COPOLYMER; DOXORUBICIN; N (2 HYDROXYPROPYL)METHYLACRYLAMIDE COPOLYMER; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; N-(2-HYDROXYPROPYL)METHACRYLAMIDE; N-(2-HYDROXYPROPYL)METHACRYLAMIDE CO-POLYMER-DOXORUBICIN CONJUGATE;

EID: 85012050573     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.1080/17435390.2017.1285071     Document Type: Article
Times cited : (21)

References (48)
  • 1
    • 84939898052 scopus 로고    scopus 로고
    • Acute acepromazine overdose: clinical effects and toxicokinetic evaluation
    • Algren DA, Ashworth A., 2015. Acute acepromazine overdose:clinical effects and toxicokinetic evaluation. J Med Toxicol 11:121–3.
    • (2015) J Med Toxicol , vol.11 , pp. 121-123
    • Algren, D.A.1    Ashworth, A.2
  • 2
    • 0037365845 scopus 로고    scopus 로고
    • Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings
    • Bertinchant J, Polge A, Juan J, Oliva-Lauraire M, Giuliani I, Marty-Double C, et al. 2003. Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings. Clin Chim Acta 329:39–51.
    • (2003) Clin Chim Acta , vol.329 , pp. 39-51
    • Bertinchant, J.1    Polge, A.2    Juan, J.3    Oliva-Lauraire, M.4    Giuliani, I.5    Marty-Double, C.6
  • 3
    • 2942522528 scopus 로고    scopus 로고
    • Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy
    • Cardinale D, Sandri MT, Colombo A, Colombo N, Boeri M, Lamantia G, et al. 2004. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation 109:2749–54.
    • (2004) Circulation , vol.109 , pp. 2749-2754
    • Cardinale, D.1    Sandri, M.T.2    Colombo, A.3    Colombo, N.4    Boeri, M.5    Lamantia, G.6
  • 6
    • 84866599720 scopus 로고    scopus 로고
    • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines
    • Curigliano G, Cardinale D, Suter T, Plataniotis G, De Azambuja E, Sandri MT, et al. 2012. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy:ESMO Clinical Practice Guidelines. Ann Oncol 23:vii155–66.
    • (2012) Ann Oncol , vol.23 , pp. vii155-vii166
    • Curigliano, G.1    Cardinale, D.2    Suter, T.3    Plataniotis, G.4    De Azambuja, E.5    Sandri, M.T.6
  • 7
    • 33947195336 scopus 로고    scopus 로고
    • Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats
    • Dharmani M, Mustafa MR, Achike FI, Sim M-K., 2007. Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats. Eur J Pharmacol 561:144–50.
    • (2007) Eur J Pharmacol , vol.561 , pp. 144-150
    • Dharmani, M.1    Mustafa, M.R.2    Achike, F.I.3    Sim, M.-K.4
  • 9
    • 84890468556 scopus 로고    scopus 로고
    • Heart rate variability is a predictor of mortality in chronic kidney disease: a report from the CRIC Study
    • Drawz PE, Babineau DC, Brecklin C, HE J, Kallem RR, Soliman EZ, et al. 2013. Heart rate variability is a predictor of mortality in chronic kidney disease:a report from the CRIC Study. Am J Nephrol 38:517–28.
    • (2013) Am J Nephrol , vol.38 , pp. 517-528
    • Drawz, P.E.1    Babineau, D.C.2    Brecklin, C.3    He, J.4    Kallem, R.R.5    Soliman, E.Z.6
  • 10
    • 0031933130 scopus 로고    scopus 로고
    • Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymer doxorubicin (PK1)
    • Duncan R, Coatsworth JK, Burtles S., 1998. Preclinical toxicology of a novel polymeric antitumour agent:HPMA copolymer doxorubicin (PK1). Hum Exp Toxicol 17:93–104.
    • (1998) Hum Exp Toxicol , vol.17 , pp. 93-104
    • Duncan, R.1    Coatsworth, J.K.2    Burtles, S.3
  • 11
    • 75749112452 scopus 로고    scopus 로고
    • Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities
    • Duncan R, Vicent MJ., 2010. Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities. Adv Drug Deliv Rev 62:272–82.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 272-282
    • Duncan, R.1    Vicent, M.J.2
  • 13
    • 68949166354 scopus 로고    scopus 로고
    • Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture
    • Fox ME, Szoka FC, Fréchet JMJ., 2009. Soluble polymer carriers for the treatment of cancer:the importance of molecular architecture. Acc Chem Res 42:1141–51.
    • (2009) Acc Chem Res , vol.42 , pp. 1141-1151
    • Fox, M.E.1    Szoka, F.C.2    Fréchet, J.M.J.3
  • 14
    • 84884363992 scopus 로고    scopus 로고
    • Activation of the Mas receptor by angiotensin-(1–7) in the renin–angiotensin system mediates mesenteric vasodilatation in cirrhosis
    • Grace JA, Klein S, Herath CB, Granzow M, Schierwagen R, Masing N, et al. 2013. Activation of the Mas receptor by angiotensin-(1–7) in the renin–angiotensin system mediates mesenteric vasodilatation in cirrhosis. Gastroenterology 145:874–84.
    • (2013) Gastroenterology , vol.145 , pp. 874-884
    • Grace, J.A.1    Klein, S.2    Herath, C.B.3    Granzow, M.4    Schierwagen, R.5    Masing, N.6
  • 16
    • 48949117176 scopus 로고    scopus 로고
    • Echocardiography, a non-invasive method for the assessment of cardiac function and morphology in preclinical drug toxicology and safety pharmacology
    • Hanton G, Eder V, Rochefort G, Bonnet P, Hyvelin JM., 2008. Echocardiography, a non-invasive method for the assessment of cardiac function and morphology in preclinical drug toxicology and safety pharmacology. Exp Opin Drug Metab Toxicol 4:681–96.
    • (2008) Exp Opin Drug Metab Toxicol , vol.4 , pp. 681-696
    • Hanton, G.1    Eder, V.2    Rochefort, G.3    Bonnet, P.4    Hyvelin, J.M.5
  • 17
    • 0035667083 scopus 로고    scopus 로고
    • Preclinical evaluation of the cardiotoxicity of PK2: a novel HPMA copolymer–doxorubicin–galactosamine conjugate antitumour agent
    • Hopewell WJ, Duncan R, Wilding D, Chakrabarti K., 2001. Preclinical evaluation of the cardiotoxicity of PK2:a novel HPMA copolymer–doxorubicin–galactosamine conjugate antitumour agent. Hum Exp Toxicol 20:461–70.
    • (2001) Hum Exp Toxicol , vol.20 , pp. 461-470
    • Hopewell, W.J.1    Duncan, R.2    Wilding, D.3    Chakrabarti, K.4
  • 18
    • 0025329486 scopus 로고
    • Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers
    • Japundzic N, Grichois ML, Zitoun P, Laude D, Elghozi JL., 1990. Spectral analysis of blood pressure and heart rate in conscious rats:effects of autonomic blockers. J Auton Nerv Syst 30:91–100.
    • (1990) J Auton Nerv Syst , vol.30 , pp. 91-100
    • Japundzic, N.1    Grichois, M.L.2    Zitoun, P.3    Laude, D.4    Elghozi, J.L.5
  • 19
    • 0031810322 scopus 로고    scopus 로고
    • Physiological mechanisms in regulation of blood pressure fast frequency variations
    • Japundzic-Zigon N., 1998. Physiological mechanisms in regulation of blood pressure fast frequency variations. Clin Exp Hypertens 20:359–88.
    • (1998) Clin Exp Hypertens , vol.20 , pp. 359-388
    • Japundzic-Zigon, N.1
  • 21
    • 78649810957 scopus 로고    scopus 로고
    • Advances in polymeric micelles for drug delivery and tumor targeting
    • Kedar U, Phutane P, Shidhaye S, Kadam V., 2010. Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine 6:714–29.
    • (2010) Nanomedicine , vol.6 , pp. 714-729
    • Kedar, U.1    Phutane, P.2    Shidhaye, S.3    Kadam, V.4
  • 22
    • 0041181628 scopus 로고    scopus 로고
    • HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action
    • Kopeček J, Kopečková P, Minko T, Lu ZR., 2000. HPMA copolymer–anticancer drug conjugates:design, activity, and mechanism of action. Eur J Pharm Biopharm 50:61–81.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 61-81
    • Kopeček, J.1    Kopečková, P.2    Minko, T.3    Lu, Z.R.4
  • 23
    • 0015599832 scopus 로고
    • New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood
    • Kopeček J, Šprincl L, Lim D., 1973. New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood. J Biomed Mater Res 7:179–91.
    • (1973) J Biomed Mater Res , vol.7 , pp. 179-191
    • Kopeček, J.1    Šprincl, L.2    Lim, D.3
  • 24
    • 78650643890 scopus 로고    scopus 로고
    • Adriamycin nephropathy: a model of focal segmental glomerulosclerosis
    • Lee VW, Harris DC., 2011. Adriamycin nephropathy:a model of focal segmental glomerulosclerosis. Nephrology (Carlton) 16:30–8.
    • (2011) Nephrology (Carlton) , vol.16 , pp. 30-38
    • Lee, V.W.1    Harris, D.C.2
  • 25
    • 84925686118 scopus 로고    scopus 로고
    • Heart rate dynamics in doxorubicin-induced cardiomyopathy
    • T, Vasi? M, Tasi? T, Mijatovi? G, Glumac S, Baji? D
    • Lončar-Turukalo T, Vasi? M, Tasi? T, Mijatovi? G, Glumac S, Baji? D, T, Vasić M, Tasić T, Mijatović G, Glumac S, Bajić D, et al. 2015. Heart rate dynamics in doxorubicin-induced cardiomyopathy. Physiol Meas 36:727–39.
    • (2015) Physiol Meas , vol.36 , pp. 727-739
    • Lončar-Turukalo, T.1    Vasić, M.2    Tasić, T.3    Mijatović, G.4    Glumac, S.5    Bajić, D.6
  • 27
    • 36048953413 scopus 로고    scopus 로고
    • Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells
    • Malugin A, Kopečková P, Kopeček J., 2007. Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. J Control Release 124:6–10.
    • (2007) J Control Release , vol.124 , pp. 6-10
    • Malugin, A.1    Kopečková, P.2    Kopeček, J.3
  • 29
    • 84902000342 scopus 로고    scopus 로고
    • Chemotherapy-induced neuropathy: a comprehensive survey
    • Miltenburg N, Boogerd W., 2014. Chemotherapy-induced neuropathy:a comprehensive survey. Cancer Treat Rev 40:872–82.
    • (2014) Cancer Treat Rev , vol.40 , pp. 872-882
    • Miltenburg, N.1    Boogerd, W.2
  • 30
    • 84949033622 scopus 로고    scopus 로고
    • Doxorubicin induced heart failure: phenotype and molecular mechanisms
    • Mitry MA, Edwards JG., 2016. Doxorubicin induced heart failure:phenotype and molecular mechanisms. Int J Cardiol Heart Vasc 10:17–24.
    • (2016) Int J Cardiol Heart Vasc , vol.10 , pp. 17-24
    • Mitry, M.A.1    Edwards, J.G.2
  • 32
    • 84963808130 scopus 로고    scopus 로고
    • Role of the ACE2/Angiotensin 1–7 axis of the renin–angiotensin system in heart failure
    • Patel VB, Zhong J-C, Grant MB, Oudit GY., 2016. Role of the ACE2/Angiotensin 1–7 axis of the renin–angiotensin system in heart failure. Circ Res 118:1313–26.
    • (2016) Circ Res , vol.118 , pp. 1313-1326
    • Patel, V.B.1    Zhong, J.-C.2    Grant, M.B.3    Oudit, G.Y.4
  • 33
    • 0030741885 scopus 로고    scopus 로고
    • Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    • Ponikowski P, Anker SD, Chua TP, Szelemej JR, Piepoli M, Adamopoulos S, et al. 1997. Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 79:1645–50.
    • (1997) Am J Cardiol , vol.79 , pp. 1645-1650
    • Ponikowski, P.1    Anker, S.D.2    Chua, T.P.3    Szelemej, J.R.4    Piepoli, M.5    Adamopoulos, S.6
  • 34
    • 44449087382 scopus 로고    scopus 로고
    • Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV
    • Ranpuria R, Hall M, Chan CT, Unruh M., 2008. Heart rate variability (HRV) in kidney failure:measurement and consequences of reduced HRV. Nephrol Dial Transplant 23:444–9.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 444-449
    • Ranpuria, R.1    Hall, M.2    Chan, C.T.3    Unruh, M.4
  • 35
    • 79956009044 scopus 로고    scopus 로고
    • Autonomic mechanisms underpinning the stress response in borderline hypertensive rats
    • Šarenac O, Lozić M, Drakulić S, Bajić D, Paton JF, Murphy D, et al. 2011. Autonomic mechanisms underpinning the stress response in borderline hypertensive rats. Exp Physiol 96:574–89.
    • (2011) Exp Physiol , vol.96 , pp. 574-589
    • Šarenac, O.1    Lozić, M.2    Drakulić, S.3    Bajić, D.4    Paton, J.F.5    Murphy, D.6
  • 36
    • 79954593490 scopus 로고    scopus 로고
    • Early detection and prediction of cardiotoxicity in chemotherapy-treated patients
    • Sawaya H, Sebag IA, Plana JC, Januzzi JL, KY B, Cohen V, et al. 2011. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol 107:1375–80.
    • (2011) Am J Cardiol , vol.107 , pp. 1375-1380
    • Sawaya, H.1    Sebag, I.A.2    Plana, J.C.3    Januzzi, J.L.4    Ky, B.5    Cohen, V.6
  • 37
    • 67649417879 scopus 로고    scopus 로고
    • Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer
    • Seymour LW, Ferry DR, Kerr DJ, Rea D, Whitlock M, Poyner R, et al. 2009. Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol 34:1629–36.
    • (2009) Int J Oncol , vol.34 , pp. 1629-1636
    • Seymour, L.W.1    Ferry, D.R.2    Kerr, D.J.3    Rea, D.4    Whitlock, M.5    Poyner, R.6
  • 38
    • 82555176568 scopus 로고    scopus 로고
    • A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy
    • Sipola P, Vanninen E, Jantunen E, Nousiainen T, Kiviniemi M, Hartikainen J, et al. 2012. A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy. Nucl Med Commun 33:51–9.
    • (2012) Nucl Med Commun , vol.33 , pp. 51-59
    • Sipola, P.1    Vanninen, E.2    Jantunen, E.3    Nousiainen, T.4    Kiviniemi, M.5    Hartikainen, J.6
  • 39
    • 33845593309 scopus 로고    scopus 로고
    • Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats
    • Stein AB, Tiwari IS, Thomas P, Hunt G, Levent C, Stoddard MF, et al. 2007. Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. Basic Res Cardiol 102:28–41.
    • (2007) Basic Res Cardiol , vol.102 , pp. 28-41
    • Stein, A.B.1    Tiwari, I.S.2    Thomas, P.3    Hunt, G.4    Levent, C.5    Stoddard, M.F.6
  • 41
    • 84890873913 scopus 로고    scopus 로고
    • Heart rate variability in type 2 diabetes mellitus
    • Stuckey MI, Petrella RJ., 2013. Heart rate variability in type 2 diabetes mellitus. Crit Rev Biomed Eng 41:137–47.
    • (2013) Crit Rev Biomed Eng , vol.41 , pp. 137-147
    • Stuckey, M.I.1    Petrella, R.J.2
  • 42
    • 0034533719 scopus 로고    scopus 로고
    • Progressive cardiac dysfunction in adriamycin‐induced cardiomyopathy rats
    • Teraoka K, Hirano M, Yamaguchi K, Yamashina A., 2000. Progressive cardiac dysfunction in adriamycin‐induced cardiomyopathy rats. Eur J Heart Fail 2:373–8.
    • (2000) Eur J Heart Fail , vol.2 , pp. 373-378
    • Teraoka, K.1    Hirano, M.2    Yamaguchi, K.3    Yamashina, A.4
  • 43
    • 84961346074 scopus 로고    scopus 로고
    • The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia
    • Tomalova AB, Sirova M, Rossmann P, Pola R, Strohalm J, Chytil P, et al. 2016. The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia. J Control Release 223:1–10.
    • (2016) J Control Release , vol.223 , pp. 1-10
    • Tomalova, A.B.1    Sirova, M.2    Rossmann, P.3    Pola, R.4    Strohalm, J.5    Chytil, P.6
  • 44
    • 0025908397 scopus 로고
    • Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats
    • Tong J, Ganguly P, Singal P., 1991. Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats. Am J Physiol 260:H909–16.
    • (1991) Am J Physiol , vol.260 , pp. H909-H916
    • Tong, J.1    Ganguly, P.2    Singal, P.3
  • 45
    • 0032959549 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee
    • Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, et al. 1999. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]:first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin Cancer Res 5:83–94.
    • (1999) Clin Cancer Res , vol.5 , pp. 83-94
    • Vasey, P.A.1    Kaye, S.B.2    Morrison, R.3    Twelves, C.4    Wilson, P.5    Duncan, R.6
  • 47
    • 0025918134 scopus 로고
    • Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl) methacrylamide conjugates: and experimental study in the rat
    • Yeung TK, Hopewell JW, Simmonds RH, Seymour LW, Duncan R, Bellini O, et al. 1991. Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl) methacrylamide conjugates:and experimental study in the rat. Cancer Chemother Pharmacol 29:105–11.
    • (1991) Cancer Chemother Pharmacol , vol.29 , pp. 105-111
    • Yeung, T.K.1    Hopewell, J.W.2    Simmonds, R.H.3    Seymour, L.W.4    Duncan, R.5    Bellini, O.6
  • 48
    • 84904299687 scopus 로고    scopus 로고
    • Polymeric micelles as drug carriers: their lights and shadows
    • Yokoyama M., 2014. Polymeric micelles as drug carriers:their lights and shadows. J Drug Target 22:576–83.
    • (2014) J Drug Target , vol.22 , pp. 576-583
    • Yokoyama, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.