Activation of the mas receptor by angiotensin-(1-7) in the renin-angiotensin system mediates mesenteric vasodilatation in cirrhosis

Gastroenterology

Volumn 145, Issue 4, 2013, Pages

  Grace, Josephine A ^a,b   Klein, Sabine ^c   Herath, Chandana B ^a   Granzow, Michaela ^c   Schierwagen, Robert ^c   Masing, Noemi ^c   Walther, Thomas ^d,e   Sauerbruch, Tilman ^c   Burrell, Louise M ^a   Angus, Peter W ^a,b   Trebicka, Jonel ^c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY COLLEGE CORK   (Ireland)

^e UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Rat Model Portal Hypertension BDL Hemodynamics

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MAS RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; BLOOD VESSEL WALL; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; HEMODYNAMICS; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; MESENTERIC VEIN; MESENTERY BLOOD FLOW; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPLANCHNIC BLOOD FLOW; SPLANCHNIC NERVE; UPREGULATION; VASCULAR RESISTANCE; VASODILATATION;

EID: 84884363992     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.06.036     Document Type: Article

References (55)

1. A.J. Macgilchrist, L.G. Howes, and C. Hawksby Plasma noradrenaline in cirrhosis: a study of kinetics and temporal relationship to ascites formation Eur J Clin Invest 21 1991 238 243
2. R. Bataller, E. Gabele, and C.J. Parsons Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats Hepatology 41 2005 1046 1055
3. R. Bataller, P. Gines, and J.M. Nicolas Angiotensin II induces contraction and proliferation of human hepatic stellate cells Gastroenterology 118 2000 1149 1156
4. S.R. Tipnis, N.M. Hooper, and R. Hyde A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase J Biol Chem 275 2000 33238 33243
5. M. Donoghue, F. Hsieh, and E. Baronas A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Circ Res 87 2000 E1 E9
6. M.A. Oliveira, Z.B. Fortes, and R.A. Santos Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo Peptides 20 1999 1195 1201
7. J.S. Lubel, C.B. Herath, and J. Tchongue Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat Clin Sci 117 2009 375 386
8. W.W. Vilas-Boas, A. Ribeiro-Oliveira Jr., and R.M. Pereira Relationship between angiotensin-(1-7) and angiotensin II correlates with hemodynamic changes in human liver cirrhosis World J Gastroenterol 15 2009 2512 2519
9. G. Paizis, C. Tikellis, and M.E. Cooper Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2 Gut 54 2005 1790 1796
10. C.B. Herath, F.J. Warner, and J.S. Lubel Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis J Hepatol 47 2007 387 395
11. D.D. McGregor The effect of sympathetic nerve stimulation of vasoconstrictor responses in perfused mesenteric blood vessels of the rat J Physiol 177 1965 21 30
12. C.B. Herath, J.S. Lubel, and Z. Jia Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2 Am J Physiol Gastrointest Liver Physiol 297 2009 97 106
13. J. Trebicka, M. Hennenberg, and A. Schulze Probsting Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis Hepatology 50 2009 1924 1935
14. J. Trebicka, M. Hennenberg, and W. Laleman Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 2007 242 253
15. W.O. Sampaio, R.A. Souza dos Santos, and R. Faria-Silva Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways Hypertension 49 2007 185 192
16. C.C. Sieber, and R.J. Groszmann Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats Gastroenterology 103 1992 235 239
17. R.W. Schrier, V. Arroyo, and M. Bernardi Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis Hepatology 8 1988 1151 1157
18. R.A.S. Santos, K.B. Brosnihan, and D.W. Jacobsen Production of angiotensin-(1-7) by human vascular endothelium Hypertension 19 1992 56 61
19. M. Schepke, J. Heller, and S. Paschke Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: evidence for a receptor-specific mechanism Hepatology 34 2001 884 888
20. B.M. Murray, and M.S. Paller Decreased pressor reactivity to angiotensin II in cirrhotic rats. Evidence for a post-receptor defect in angiotensin action Circ Res 57 1985 424 431
21. M. Hennenberg, J. Trebicka, and E. Biecker Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins Hepatology 45 2007 495 506
22. W.O. Sampaio, A.A.S. Nascimento, and R.A.S. Santos Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats Am J Physiol Heart Circ Physiol 2003 284
23. R.A. Santos, A.C. Simoes e Silva, and C. Maric Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas Proc Natl Acad Sci U S A 100 2003 8258 8263
24. R. Metzger, M. Bader, and T. Ludwig Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues FEBS Lett 357 1995 27 32
25. E. Kostenis, G. Milligan, and A. Christopoulos G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor Circulation 111 2005 1806 1813
26. L.K. Becker, G.M. Etelvino, and T. Walther Immunofluorescence localization of the receptor Mas in cardiovascular- related areas of the rat brain Am J Physiol Heart Circ Physiol 2007 293
27. L.S. Lara, D. Vives, and J.S. Correa PKA-mediated effect of MAS receptor in counteracting angiotensin II-stimulated renal Na+-ATPase Arch Biochem Biophys 496 2010 117 122
28. S. Dimmeler, I. Fleming, and B. Fisslthaler Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 1999 601 605
29. P.F. Mount, B.E. Kemp, and D.A. Power Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation J Mol Cell Cardiol 42 2007 271 279
30. J.W. Ferguson, A.R. Dover, and S. Chia Inducible nitric oxide synthase activity contributes to the regulation of peripheral vascular tone in patients with cirrhosis and ascites Gut 55 2006 542 546
31. H. Heitsch, S. Brovkovych, and T. Malinski Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells Hypertension 37 2001 72 76
32. S. Tesanovic, A. Vinh, and T.A. Gaspari Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol 30 2010 1606 1613
33. E.A. Tallant, X. Lu, and R.B. Weiss Bovine aortic endothelial cells contain an angiotensin-(1-7) receptor Hypertension 29 1997 388 393
34. C. De Mey, and P.M. Vanhoutte Effect of age and spontaneous hypertension on the tachyphylaxis to 5-hydroxytryptamine and angiotensin II in the isolated rat kidney Hypertension 3 1981 718 724
35. R.E. Widdop, K. Matrougui, and B.I. Levy AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade Hypertension 40 2002 516 520
36. W.G. Thomas, and F.A.O. Mendelsohn Angiotensin receptors: form and function and distribution Int J Biochem Cell Biol 35 2003 774 779
37. P. Tandon, J.G. Abraldes, and A. Berzigotti Renin-angiotensin-aldosterone inhibitors in the reduction of portal pressure: a systematic review and meta-analysis J Hepatol 53 2010 273 282
38. M. Schepke, E. Werner, and E. Biecker Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension Gastroenterology 121 2001 389 395
39. M. Hennenberg, J. Trebicka, and E. Biecker Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins Hepatology 45 2007 495 506
40. G. Paizis, M.E. Cooper, and J.M. Schembri Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver Gastroenterology 123 2002 1667 1676
41. C.C. Sieber, J.C. Lopez-Talavera, and R.J. Groszmann Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats Gastroenterology 104 1993 1750 1754
42. L.A. Neves, A.F. Williams, and D.B. Averill Pregnancy enhances the angiotensin (Ang)-(1-7) vasodilator response in mesenteric arteries and increases the renal concentration and urinary excretion of Ang-(1-7) Endocrinology 144 2003 3338 3343
43. M. Dharmani, M.R. Mustafa, and F.I. Achike Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats Eur J Pharmacol 561 2007 144 150
44. P. Li, M.C. Chappell, and C.M. Ferrario Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide Hypertension 29 1997 394 398
45. K. Matrougui, L. Loufrani, and C. Heymes Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries Hypertension 34 1999 659 665
46. C. Peiro, S. Vallejo, and F. Gembardt Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function J Hypertens 25 2007 2421 2425
47. C.B. Herath, J.S. Lubel, and Z. Jia Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2 Am J Physiol Gastrointest Liver Physiol 297 2009 97 106
48. M. Byku, H. Macarthur, and T.C. Westfall Inhibitory effects of angiotensin-(1-7) on the nerve stimulation-induced release of norepinephrine and neuropeptide Y from the mesenteric arterial bed Am J Physiol Heart Circ Physiol 298 2010 H457 H465
49. J.S. Lubel, C.B. Herath, and J. Tchongue Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat Clin Sci 117 2009 375 386
50. W.C. Seyde, and D.E. Longnecker Anesthetic influences on regional hemodynamics in normal and hemorrhaged rats Anesthesiology 61 1984 686 698
51. M. Van de Casteele, H. Sägesser, and H. Zimmermann Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow Pharmacol Ther 90 2001 35 43
52. J. Trebicka, M. Hennenberg, and W. Laleman Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 2007 242 253
53. J.P. Hakkinen, M.W. Miller, and A.H. Smith Measurement of organ blood flow with coloured microspheres in the rat Cardiovasc Res 29 1995 74 79
54. J. Trebicka, M. Hennenberg, and A. Schulze Probsting Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis Hepatology 50 2009 1924 1935
55. J.G. Geraghty, W.J. Angerson, and D.C. Carter Portal venous pressure and portasystemic shunting in experimental portal hypertension Am J Physiol 257 1989 G52 G57