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Volumn 6, Issue 2, 2017, Pages

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

Author keywords

Galectin 9; hepatocellular carcinoma; HVEM; IDO; PD L1; tissue microarrays; tumor infiltrating lymphocytes

Indexed keywords

CD8 ANTIGEN; ECALECTIN; HERPESVIRUS ENTRY MEDIATOR; INDOLEAMINE 2,3 DIOXYGENASE; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1;

EID: 85012041427     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1273309     Document Type: Article
Times cited : (126)

References (59)
  • 2
    • 42949174616 scopus 로고    scopus 로고
    • Diagnosis and treatment of hepatocellular carcinoma
    • 18471552
    • El-Serag HB, Marrero JA, Rudolph L, Reddy KR. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008; 134:1752-63; PMID:18471552; http://dx.doi.org/10.1053/j.gastro.2008.02.090
    • (2008) Gastroenterology , vol.134 , pp. 1752-1763
    • El-Serag, H.B.1    Marrero, J.A.2    Rudolph, L.3    Reddy, K.R.4
  • 4
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • 22193102
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011; 480:480-9; PMID:22193102; http://dx.doi.org/10.1038/nature10673
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 5
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • 15776005
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005; 5:263-74; PMID:15776005; http://dx.doi.org/10.1038/nrc1586
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 8
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
    • 26115796
    • Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, Hodi FS, Schachter J, Pavlick AC, Lewis KD, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002):a randomised, controlled, phase 2 trial. Lancet Oncol 2015; 16:908-18; PMID:26115796; http://dx.doi.org/10.1016/S1470-2045(15)00083-2
    • (2015) Lancet Oncol , vol.16 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3    Schadendorf, D.4    Hamid, O.5    Robert, C.6    Hodi, F.S.7    Schachter, J.8    Pavlick, A.C.9    Lewis, K.D.10
  • 9
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    • 25704439
    • Rizvi NA, Mazieres J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063):a phase 2, single-arm trial. Lancet Oncol 2015; 16:257-65; PMID:25704439; http://dx.doi.org/10.1016/S1470-2045(15)70054-9
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6    Horn, L.7    Lena, H.8    Minenza, E.9    Mennecier, B.10
  • 10
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • 26952546
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, Dawson N, O'Donnell PH, Balmanoukian A, Loriot Y, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy:a single-arm, multicentre, phase 2 trial. Lancet 2016; 387:1909-20; PMID:26952546; http://dx.doi.org/10.1016/S0140-6736(16)00561-4
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6    Dawson, N.7    O'Donnell, P.H.8    Balmanoukian, A.9    Loriot, Y.10
  • 11
    • 84896702241 scopus 로고    scopus 로고
    • Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies
    • 24315741
    • Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M. Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Cancer Treat Rev 2014; 40:513-22; PMID:24315741; http://dx.doi.org/10.1016/j.ctrv.2013.11.005
    • (2014) Cancer Treat Rev , vol.40 , pp. 513-522
    • Sideras, K.1    Braat, H.2    Kwekkeboom, J.3    van Eijck, C.H.4    Peppelenbosch, M.P.5    Sleijfer, S.6    Bruno, M.7
  • 12
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • 18173375
    • Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677-704; PMID:18173375; http://dx.doi.org/10.1146/annurev.immunol.26.021607.090331
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3    Sharpe, A.H.4
  • 13
    • 84857743064 scopus 로고    scopus 로고
    • Immunological and molecular correlates of disease recurrence after liver resection for hepatocellular carcinoma
    • 22396772
    • Cariani E, Pilli M, Zerbini A, Rota C, Olivani A, Pelosi G, Schianchi C, Soliani P, Campanini N, Silini EM, et al. Immunological and molecular correlates of disease recurrence after liver resection for hepatocellular carcinoma. PLoS One 2012; 7:e32493; PMID:22396772; http://dx.doi.org/10.1371/journal.pone.0032493
    • (2012) PLoS One , vol.7 , pp. e32493
    • Cariani, E.1    Pilli, M.2    Zerbini, A.3    Rota, C.4    Olivani, A.5    Pelosi, G.6    Schianchi, C.7    Soliani, P.8    Campanini, N.9    Silini, E.M.10
  • 14
    • 84856747778 scopus 로고    scopus 로고
    • Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas
    • 21853301
    • Chen J, Li G, Meng H, Fan Y, Song Y, Wang S, Zhu F, Guo C, Zhang L, Shi Y. Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas. Cancer Immunol Immunother 2012; 61:101-8; PMID:21853301; http://dx.doi.org/10.1007/s00262-011-1094-3
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 101-108
    • Chen, J.1    Li, G.2    Meng, H.3    Fan, Y.4    Song, Y.5    Wang, S.6    Zhu, F.7    Guo, C.8    Zhang, L.9    Shi, Y.10
  • 15
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • 19188168
    • Gao Q, Wang XY, Qiu SJ, Yamato I, Sho M, Nakajima Y, Zhou J, Li BZ, Shi YH, Xiao YS, et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 2009; 15:971-9; PMID:19188168; http://dx.doi.org/10.1158/1078-0432.CCR-08-1608
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.Y.2    Qiu, S.J.3    Yamato, I.4    Sho, M.5    Nakajima, Y.6    Zhou, J.7    Li, B.Z.8    Shi, Y.H.9    Xiao, Y.S.10
  • 16
    • 80051604040 scopus 로고    scopus 로고
    • B7-H1 up-regulated expression in human hepatocellular carcinoma tissue: correlation with tumor interleukin-10 levels
    • 21830424
    • Geng L, Deng J, Jiang G, Song P, Wang Z, Jiang Z, Zhang M, Zheng S. B7-H1 up-regulated expression in human hepatocellular carcinoma tissue:correlation with tumor interleukin-10 levels. Hepatogastroenterology 2011; 58:960-4; PMID:21830424
    • (2011) Hepatogastroenterology , vol.58 , pp. 960-964
    • Geng, L.1    Deng, J.2    Jiang, G.3    Song, P.4    Wang, Z.5    Jiang, Z.6    Zhang, M.7    Zheng, S.8
  • 17
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • 19451266
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, Zheng L. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009; 206:1327-37; PMID:19451266; http://dx.doi.org/10.1084/jem.20082173
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6    Zheng, L.7
  • 18
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • 19826049
    • Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res 2009; 69:8067-75; PMID:19826049; http://dx.doi.org/10.1158/0008-5472.CAN-09-0901
    • (2009) Cancer Res , vol.69 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 19
    • 79960735970 scopus 로고    scopus 로고
    • Interleukin-17-educated monocytes suppress cytotoxic T-cell function through B7-H1 in hepatocellular carcinoma patients
    • 21674477
    • Zhao Q, Xiao X, Wu Y, Wei Y, Zhu LY, Zhou J, Kuang DM. Interleukin-17-educated monocytes suppress cytotoxic T-cell function through B7-H1 in hepatocellular carcinoma patients. Eur J Immunol 2011; 41:2314-22; PMID:21674477; http://dx.doi.org/10.1002/eji.201041282
    • (2011) Eur J Immunol , vol.41 , pp. 2314-2322
    • Zhao, Q.1    Xiao, X.2    Wu, Y.3    Wei, Y.4    Zhu, L.Y.5    Zhou, J.6    Kuang, D.M.7
  • 20
    • 84876834970 scopus 로고    scopus 로고
    • Therapeutic potential of Galectin-9 in human disease
    • 21793015
    • Wiersma VR, de Bruyn M, Helfrich W, Bremer E. Therapeutic potential of Galectin-9 in human disease. Med Res Rev 2013; 33 Suppl 1:E102-26; PMID:21793015; http://dx.doi.org/10.1002/med.20249
    • (2013) Med Res Rev , vol.33 , pp. E102-E126
    • Wiersma, V.R.1    de Bruyn, M.2    Helfrich, W.3    Bremer, E.4
  • 21
    • 84867144615 scopus 로고    scopus 로고
    • Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
    • 22505239
    • Li H, Wu K, Tao K, Chen L, Zheng Q, Lu X, Liu J, Shi L, Liu C, Wang G, et al. Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma. Hepatology 2012; 56:1342-51; PMID:22505239; http://dx.doi.org/10.1002/hep.25777
    • (2012) Hepatology , vol.56 , pp. 1342-1351
    • Li, H.1    Wu, K.2    Tao, K.3    Chen, L.4    Zheng, Q.5    Lu, X.6    Liu, J.7    Shi, L.8    Liu, C.9    Wang, G.10
  • 24
    • 84962646941 scopus 로고    scopus 로고
    • Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway
    • 27028892
    • Wang Y, Sun J, Ma C, Gao W, Song B, Xue H, Chen W, Chen X, Zhang Y, Shao Q, et al. Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway. PLoS One 2016; 11:e0152599; PMID:27028892; http://dx.doi.org/10.1371/journal.pone.0152599
    • (2016) PLoS One , vol.11 , pp. e0152599
    • Wang, Y.1    Sun, J.2    Ma, C.3    Gao, W.4    Song, B.5    Xue, H.6    Chen, W.7    Chen, X.8    Zhang, Y.9    Shao, Q.10
  • 26
    • 0037142179 scopus 로고    scopus 로고
    • Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance
    • 12115481
    • Kageshita T, Kashio Y, Yamauchi A, Seki M, Abedin MJ, Nishi N, Shoji H, Nakamura T, Ono T, Hirashima M. Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. Int J Cancer 2002; 99:809-16; PMID:12115481; http://dx.doi.org/10.1002/ijc.10436
    • (2002) Int J Cancer , vol.99 , pp. 809-816
    • Kageshita, T.1    Kashio, Y.2    Yamauchi, A.3    Seki, M.4    Abedin, M.J.5    Nishi, N.6    Shoji, H.7    Nakamura, T.8    Ono, T.9    Hirashima, M.10
  • 27
    • 84874088827 scopus 로고    scopus 로고
    • Galectin-9 acts as a prognostic factor with antimetastatic potential in hepatocellular carcinoma
    • 22938412
    • Zhang ZY, Dong JH, Chen YW, Wang XQ, Li CH, Wang J, Wang GQ, Li HL, Wang XD. Galectin-9 acts as a prognostic factor with antimetastatic potential in hepatocellular carcinoma. Asian Pac J Cancer Prev 2012; 13:2503-9; PMID:22938412; http://dx.doi.org/10.7314/APJCP.2012.13.6.2503
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2503-2509
    • Zhang, Z.Y.1    Dong, J.H.2    Chen, Y.W.3    Wang, X.Q.4    Li, C.H.5    Wang, J.6    Wang, G.Q.7    Li, H.L.8    Wang, X.D.9
  • 28
    • 84865029272 scopus 로고    scopus 로고
    • The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy
    • 22445654
    • Pasero C, Speiser DE, Derre L, Olive D. The HVEM network:new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr Opin Pharmacol 2012; 12:478-85; PMID:22445654; http://dx.doi.org/10.1016/j.coph.2012.03.001
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 478-485
    • Pasero, C.1    Speiser, D.E.2    Derre, L.3    Olive, D.4
  • 29
    • 74949125667 scopus 로고    scopus 로고
    • BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
    • 20038811
    • Derre L, Rivals JP, Jandus C, Pastor S, Rimoldi D, Romero P, Michielin O, Olive D, Speiser DE. BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest 2010; 120:157-67; PMID:20038811; http://dx.doi.org/10.1172/JCI40070
    • (2010) J Clin Invest , vol.120 , pp. 157-167
    • Derre, L.1    Rivals, J.P.2    Jandus, C.3    Pastor, S.4    Rimoldi, D.5    Romero, P.6    Michielin, O.7    Olive, D.8    Speiser, D.E.9
  • 30
    • 84925385340 scopus 로고    scopus 로고
    • Clinical impact of herpesvirus entry mediator expression in human hepatocellular carcinoma
    • 25468715
    • Hokuto D, Sho M, Yamato I, Yasuda S, Obara S, Nomi T, Nakajima Y. Clinical impact of herpesvirus entry mediator expression in human hepatocellular carcinoma. Eur J Cancer 2015; 51:157-65; PMID:25468715; http://dx.doi.org/10.1016/j.ejca.2014.11.004
    • (2015) Eur J Cancer , vol.51 , pp. 157-165
    • Hokuto, D.1    Sho, M.2    Yamato, I.3    Yasuda, S.4    Obara, S.5    Nomi, T.6    Nakajima, Y.7
  • 31
    • 84868220730 scopus 로고    scopus 로고
    • Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion
    • 23090118
    • Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer:beyond IDO and tryptophan depletion. Cancer Res 2012; 72:5435-40; PMID:23090118; http://dx.doi.org/10.1158/0008-5472.CAN-12-0569
    • (2012) Cancer Res , vol.72 , pp. 5435-5440
    • Platten, M.1    Wick, W.2    Van den Eynde, B.J.3
  • 32
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives
    • 22068654
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers:clinical and immunologic perspectives. Clin Cancer Res 2011; 17:6985-91; PMID:22068654; http://dx.doi.org/10.1158/1078-0432.CCR-11-1331
    • (2011) Clin Cancer Res , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 33
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012; 4:127ra37; PMID:22461641; http://dx.doi.org/10.1126/scitranslmed.3003689
    • (2012) Sci Transl Med , vol.4 , pp. 127ra37
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6    Chen, S.7    Klein, A.P.8    Pardoll, D.M.9    Topalian, S.L.10
  • 35
    • 84941797037 scopus 로고    scopus 로고
    • Classifying Cancers Based on T-cell Infiltration and PD-L1
    • 25977340
    • Teng MW, Ngiow SF, Ribas A, Smyth MJ. Classifying Cancers Based on T-cell Infiltration and PD-L1. Cancer Res 2015; 75:2139-45; PMID:25977340; http://dx.doi.org/10.1158/0008-5472.CAN-15-0255
    • (2015) Cancer Res , vol.75 , pp. 2139-2145
    • Teng, M.W.1    Ngiow, S.F.2    Ribas, A.3    Smyth, M.J.4
  • 39
    • 84927613720 scopus 로고    scopus 로고
    • PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics
    • 25223485
    • Massi D, Brusa D, Merelli B, Ciano M, Audrito V, Serra S, Buonincontri R, Baroni G, Nassini R, Minocci D, et al. PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics. Ann Oncol 2014; 25:2433-42; PMID:25223485; http://dx.doi.org/10.1093/annonc/mdu452
    • (2014) Ann Oncol , vol.25 , pp. 2433-2442
    • Massi, D.1    Brusa, D.2    Merelli, B.3    Ciano, M.4    Audrito, V.5    Serra, S.6    Buonincontri, R.7    Baroni, G.8    Nassini, R.9    Minocci, D.10
  • 40
    • 84885083538 scopus 로고    scopus 로고
    • B7-H1 expression is associated with poor prognosis in colorectal carcinoma and regulates the proliferation and invasion of HCT116 colorectal cancer cells
    • 24124529
    • Shi SJ, Wang LJ, Wang GD, Guo ZY, Wei M, Meng YL, Yang AG, Wen WH. B7-H1 expression is associated with poor prognosis in colorectal carcinoma and regulates the proliferation and invasion of HCT116 colorectal cancer cells. PLoS One 2013; 8:e76012; PMID:24124529; http://dx.doi.org/10.1371/journal.pone.0076012
    • (2013) PLoS One , vol.8 , pp. e76012
    • Shi, S.J.1    Wang, L.J.2    Wang, G.D.3    Guo, Z.Y.4    Wei, M.5    Meng, Y.L.6    Yang, A.G.7    Wen, W.H.8
  • 42
    • 79955518331 scopus 로고    scopus 로고
    • Overall survival and PD-L1 expression in metastasized malignant melanoma
    • 21523733
    • Gadiot J, Hooijkaas AI, Kaiser AD, van Tinteren H, van Boven H, Blank C. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 2011; 117:2192-201; PMID:21523733; http://dx.doi.org/10.1002/cncr.25747
    • (2011) Cancer , vol.117 , pp. 2192-2201
    • Gadiot, J.1    Hooijkaas, A.I.2    Kaiser, A.D.3    van Tinteren, H.4    van Boven, H.5    Blank, C.6
  • 43
    • 84924577386 scopus 로고    scopus 로고
    • Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers
    • 25662388
    • Kim MY, Koh J, Kim S, Go H, Jeon YK, Chung DH. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma:Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Lung Cancer 2015; 88:24-33; PMID:25662388; http://dx.doi.org/10.1016/j.lungcan.2015.01.016
    • (2015) Lung Cancer , vol.88 , pp. 24-33
    • Kim, M.Y.1    Koh, J.2    Kim, S.3    Go, H.4    Jeon, Y.K.5    Chung, D.H.6
  • 44
    • 84925969186 scopus 로고    scopus 로고
    • Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma
    • 25600565
    • Bellmunt J, Mullane SA, Werner L, Fay AP, Callea M, Leow JJ, Taplin ME, Choueiri TK, Hodi FS, Freeman GJ, et al. Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma. Ann Oncol 2015; 26:812-7; PMID:25600565; http://dx.doi.org/10.1093/annonc/mdv009
    • (2015) Ann Oncol , vol.26 , pp. 812-817
    • Bellmunt, J.1    Mullane, S.A.2    Werner, L.3    Fay, A.P.4    Callea, M.5    Leow, J.J.6    Taplin, M.E.7    Choueiri, T.K.8    Hodi, F.S.9    Freeman, G.J.10
  • 48
    • 84925969185 scopus 로고    scopus 로고
    • Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: results from COMPARZ, a randomized controlled trial
    • 25538263
    • Choueiri TK, Figueroa DJ, Fay AP, Signoretti S, Liu Y, Gagnon R, Deen K, Carpenter C, Benson P, Ho TH, et al. Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib:results from COMPARZ, a randomized controlled trial. Clin Cancer Res 2015; 21:1071-7; PMID:25538263; http://dx.doi.org/10.1158/1078-0432.CCR-14-1993
    • (2015) Clin Cancer Res , vol.21 , pp. 1071-1077
    • Choueiri, T.K.1    Figueroa, D.J.2    Fay, A.P.3    Signoretti, S.4    Liu, Y.5    Gagnon, R.6    Deen, K.7    Carpenter, C.8    Benson, P.9    Ho, T.H.10
  • 50
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • 12091876
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, et al. Tumor-associated B7-H1 promotes T-cell apoptosis:a potential mechanism of immune evasion. Nat Med 2002; 8:793-800; PMID:12091876; http://dx.doi.org/10.1038/nm0902-1039c
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6    Roche, P.C.7    Lu, J.8    Zhu, G.9    Tamada, K.10
  • 51
    • 79953306651 scopus 로고    scopus 로고
    • Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma
    • 21355078
    • Frigola X, Inman BA, Lohse CM, Krco CJ, Cheville JC, Thompson RH, Leibovich B, Blute ML, Dong H, Kwon ED. Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma. Clin Cancer Res 2011; 17:1915-23; PMID:21355078; http://dx.doi.org/10.1158/1078-0432.CCR-10-0250
    • (2011) Clin Cancer Res , vol.17 , pp. 1915-1923
    • Frigola, X.1    Inman, B.A.2    Lohse, C.M.3    Krco, C.J.4    Cheville, J.C.5    Thompson, R.H.6    Leibovich, B.7    Blute, M.L.8    Dong, H.9    Kwon, E.D.10
  • 52
    • 84892411125 scopus 로고    scopus 로고
    • Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer
    • Jiang J, Jin MS, Kong F, Cao D, Ma HX, Jia Z, Wang YP, Suo J, Cao X. Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer. PLoS One 2013; 8:e81799; PMID:24339967; http://dx.doi.org/10.1371/journal.pone.0081799
    • (2013) PLoS One , vol.8 , pp. e81799
    • Jiang, J.1    Jin, M.S.2    Kong, F.3    Cao, D.4    Ma, H.X.5    Jia, Z.6    Wang, Y.P.7    Suo, J.8    Cao, X.9
  • 54
    • 84940437799 scopus 로고    scopus 로고
    • Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma
    • 25716202
    • Fu H, Liu Y, Xu L, Liu W, Fu Q, Liu H, Zhang W, Xu J. Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma. Tumour Biol 2015; 36:5791-9; PMID:25716202; http://dx.doi.org/10.1007/s13277-015-3248-y
    • (2015) Tumour Biol , vol.36 , pp. 5791-5799
    • Fu, H.1    Liu, Y.2    Xu, L.3    Liu, W.4    Fu, Q.5    Liu, H.6    Zhang, W.7    Xu, J.8
  • 55
    • 33748098860 scopus 로고    scopus 로고
    • PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis
    • 16876901
    • Muhlbauer M, Fleck M, Schutz C, Weiss T, Froh M, Blank C, Scholmerich J, Hellerbrand C. PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis. J Hepatol 2006; 45:520-8; PMID:16876901; http://dx.doi.org/10.1016/j.jhep.2006.05.007
    • (2006) J Hepatol , vol.45 , pp. 520-528
    • Muhlbauer, M.1    Fleck, M.2    Schutz, C.3    Weiss, T.4    Froh, M.5    Blank, C.6    Scholmerich, J.7    Hellerbrand, C.8
  • 56
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • 23986400
    • Spranger S, Spaapen RM, Zha Y, Williams J, Meng Y, Ha TT, Gajewski TF. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 2013; 5:200ra116; PMID:23986400; http://dx.doi.org/10.1126/scitranslmed.3006504
    • (2013) Sci Transl Med , vol.5 , pp. 200ra116
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3    Williams, J.4    Meng, Y.5    Ha, T.T.6    Gajewski, T.F.7
  • 57
    • 84863012436 scopus 로고    scopus 로고
    • Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages
    • 22184722
    • Zhao Q, Kuang DM, Wu Y, Xiao X, Li XF, Li TJ, Zheng L. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J Immunol 2012; 188:1117-24; PMID:22184722; http://dx.doi.org/10.4049/jimmunol.1100164
    • (2012) J Immunol , vol.188 , pp. 1117-1124
    • Zhao, Q.1    Kuang, D.M.2    Wu, Y.3    Xiao, X.4    Li, X.F.5    Li, T.J.6    Zheng, L.7
  • 59
    • 84872132293 scopus 로고    scopus 로고
    • Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer
    • 22911397
    • Pedroza-Gonzalez A, Verhoef C, Ijzermans JN, Peppelenbosch MP, Kwekkeboom J, Verheij J, Janssen HL, Sprengers D. Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer. Hepatology 2013; 57:183-94; PMID:22911397; http://dx.doi.org/10.1002/hep.26013
    • (2013) Hepatology , vol.57 , pp. 183-194
    • Pedroza-Gonzalez, A.1    Verhoef, C.2    Ijzermans, J.N.3    Peppelenbosch, M.P.4    Kwekkeboom, J.5    Verheij, J.6    Janssen, H.L.7    Sprengers, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.