메뉴 건너뛰기




Volumn 27, Issue 12, 2016, Pages 2184-2195

Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis

Author keywords

adjuvant; breast cancer; colorectal cancer; metformin; prostate cancer; repurposing

Indexed keywords

METFORMIN;

EID: 85012027941     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdw410     Document Type: Article
Times cited : (336)

References (79)
  • 1
    • 85096656732 scopus 로고    scopus 로고
    • CRUK. Cancer Research UK Cancer Statistics, All Cancers Combined. (10 January 2016, date last accessed).
    • CRUK. Cancer Research UK Cancer Statistics, All Cancers Combined. http://publications.cancerresearchuk.org/downloads/Product/CS_KF_ALLCANCERS.pdf (10 January 2016, date last accessed).
  • 2
    • 84925450174 scopus 로고    scopus 로고
    • 40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study
    • Quaresma, M., Coleman, M.P., Rachet, B., 40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study. Lancet 385 (2015), 1206–1218.
    • (2015) Lancet , vol.385 , pp. 1206-1218
    • Quaresma, M.1    Coleman, M.P.2    Rachet, B.3
  • 3
    • 80053994835 scopus 로고    scopus 로고
    • Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?
    • Langley, R.E., Burdett, S., Tierney, J.F., et al. Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?. Br J Cancer 105 (2011), 1107–1113.
    • (2011) Br J Cancer , vol.105 , pp. 1107-1113
    • Langley, R.E.1    Burdett, S.2    Tierney, J.F.3
  • 5
    • 84944177030 scopus 로고    scopus 로고
    • Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
    • Coleman, R., Powles, T., Paterson, A., et al. Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet 386 (2015), 1353–1361.
    • (2015) Lancet , vol.386 , pp. 1353-1361
    • Coleman, R.1    Powles, T.2    Paterson, A.3
  • 6
    • 84878428458 scopus 로고    scopus 로고
    • Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
    • Park, H.S., Schoenfeld, J.D., Mailhot, R.B., et al. Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis. Ann Oncol 24 (2013), 1427–1434.
    • (2013) Ann Oncol , vol.24 , pp. 1427-1434
    • Park, H.S.1    Schoenfeld, J.D.2    Mailhot, R.B.3
  • 7
    • 85096681558 scopus 로고    scopus 로고
    • National Institute of Health and Care Excellence: Type II Diabetes CG87
    • NICE, National Institute of Health and Care Excellence: Type II Diabetes CG87. 2009.
    • (2009)
    • NICE1
  • 8
    • 35848938638 scopus 로고    scopus 로고
    • Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome
    • Costello, M., Shrestha, B., Eden, J., et al. Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev, 2007, CD005552.
    • (2007) Cochrane Database Syst Rev , pp. CD005552
    • Costello, M.1    Shrestha, B.2    Eden, J.3
  • 10
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • Dowling, R.J., Zakikhani, M., Fantus, I.G., et al. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 67 (2007), 10804–10812.
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3
  • 11
    • 84355166815 scopus 로고    scopus 로고
    • The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus
    • Fidan, E., Onder Ersoz, H., Yilmaz, M., et al. The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus. Acta Diabetol 48 (2011), 297–302.
    • (2011) Acta Diabetol , vol.48 , pp. 297-302
    • Fidan, E.1    Onder Ersoz, H.2    Yilmaz, M.3
  • 12
    • 79953661884 scopus 로고    scopus 로고
    • Understanding the benefit of metformin use in cancer treatment
    • Dowling, R.J., Goodwin, P.J., Stambolic, V., Understanding the benefit of metformin use in cancer treatment. BMC Med, 9, 2011, 33.
    • (2011) BMC Med , vol.9 , pp. 33
    • Dowling, R.J.1    Goodwin, P.J.2    Stambolic, V.3
  • 13
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
    • Hadad, S., Iwamoto, T., Jordan, L., et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat 128 (2011), 783–794.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3
  • 14
    • 84866538325 scopus 로고    scopus 로고
    • Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
    • Niraula, S., Dowling, R.J., Ennis, M., et al. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat 135 (2012), 821–830.
    • (2012) Breast Cancer Res Treat , vol.135 , pp. 821-830
    • Niraula, S.1    Dowling, R.J.2    Ennis, M.3
  • 15
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
    • Hosono, K., Endo, H., Takahashi, H., et al. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila) 3 (2010), 1077–1083.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3
  • 16
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
    • Decensi, A., Puntoni, M., Goodwin, P., et al. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res 3 (2010), 1451–1461.
    • (2010) Cancer Prev Res , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 17
    • 84907296915 scopus 로고    scopus 로고
    • Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders
    • Gandini, S., Puntoni, M., Heckman-Stoddard, B.M., et al. Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res 7 (2014), 867–885.
    • (2014) Cancer Prev Res , vol.7 , pp. 867-885
    • Gandini, S.1    Puntoni, M.2    Heckman-Stoddard, B.M.3
  • 18
    • 84876334434 scopus 로고    scopus 로고
    • Association of metformin use with cancer incidence and mortality: a meta-analysis
    • Zhang, P., Li, H., Tan, X., et al. Association of metformin use with cancer incidence and mortality: a meta-analysis. Cancer Epidemiol 37 (2013), 207–218.
    • (2013) Cancer Epidemiol , vol.37 , pp. 207-218
    • Zhang, P.1    Li, H.2    Tan, X.3
  • 19
    • 84862848716 scopus 로고    scopus 로고
    • Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis
    • Soranna, D., Scotti, L., Zambon, A., et al. Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist 17 (2012), 813–822.
    • (2012) Oncologist , vol.17 , pp. 813-822
    • Soranna, D.1    Scotti, L.2    Zambon, A.3
  • 20
    • 84858695046 scopus 로고    scopus 로고
    • Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis
    • Noto, H., Goto, A., Tsujimoto, T., Noda, M., Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One, 7, 2012, e33411.
    • (2012) PLoS One , vol.7 , pp. e33411
    • Noto, H.1    Goto, A.2    Tsujimoto, T.3    Noda, M.4
  • 21
    • 84904398047 scopus 로고    scopus 로고
    • The prognostic value of metformin for cancer patients with concurrent diabetes: a systematic review and meta-analysis
    • Zhang, Z.J., Li, S., The prognostic value of metformin for cancer patients with concurrent diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 16 (2014), 707–710.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 707-710
    • Zhang, Z.J.1    Li, S.2
  • 22
    • 84907486446 scopus 로고    scopus 로고
    • The effect of metformin on mortality following cancer among patients with diabetes
    • Lega, I.C., Shah, P.S., Margel, D., et al. The effect of metformin on mortality following cancer among patients with diabetes. Cancer Epidemiol Biomarkers Prev 23 (2014), 1974–1984.
    • (2014) Cancer Epidemiol Biomarkers Prev , vol.23 , pp. 1974-1984
    • Lega, I.C.1    Shah, P.S.2    Margel, D.3
  • 23
    • 84890016628 scopus 로고    scopus 로고
    • Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis
    • Yin, M., Zhou, J., Gorak, E.J., Quddus, F., Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis. Oncologist 18 (2013), 1248–1255.
    • (2013) Oncologist , vol.18 , pp. 1248-1255
    • Yin, M.1    Zhou, J.2    Gorak, E.J.3    Quddus, F.4
  • 24
    • 84898603942 scopus 로고    scopus 로고
    • Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis
    • Mei, Z.B., Zhang, Z.J., Liu, C.Y., et al. Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis. PLoS One, 9, 2014, e91818.
    • (2014) PLoS One , vol.9 , pp. e91818
    • Mei, Z.B.1    Zhang, Z.J.2    Liu, C.Y.3
  • 26
    • 84929275437 scopus 로고    scopus 로고
    • Impact of metformin on clinical outcomes among men with prostate cancer: a systematic review and meta-analysis
    • Raval, A.D., Thakker, D., Vyas, A., et al. Impact of metformin on clinical outcomes among men with prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 18 (2015), 110–121.
    • (2015) Prostate Cancer Prostatic Dis , vol.18 , pp. 110-121
    • Raval, A.D.1    Thakker, D.2    Vyas, A.3
  • 27
    • 84919922750 scopus 로고    scopus 로고
    • Effect of metformin on cancer risk and treatment outcome of prostate cancer: a meta-analysis of epidemiological observational studies
    • Yu, H., Yin, L., Jiang, X., et al. Effect of metformin on cancer risk and treatment outcome of prostate cancer: a meta-analysis of epidemiological observational studies. PLoS One, 9, 2014, e116327.
    • (2014) PLoS One , vol.9 , pp. e116327
    • Yu, H.1    Yin, L.2    Jiang, X.3
  • 28
    • 84946542679 scopus 로고    scopus 로고
    • Metformin use is associated with better survival of breast cancer patients with diabetes: a meta-analysis
    • Xu, H., Chen, K., Jia, X., et al. Metformin use is associated with better survival of breast cancer patients with diabetes: a meta-analysis. Oncologist 20 (2015), 1236–1244.
    • (2015) Oncologist , vol.20 , pp. 1236-1244
    • Xu, H.1    Chen, K.2    Jia, X.3
  • 29
    • 84959298298 scopus 로고    scopus 로고
    • Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial
    • Higurashi, T., Hosono, K., Takahashi, H., et al. Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. Lancet Oncol 17 (2016), 475–483.
    • (2016) Lancet Oncol , vol.17 , pp. 475-483
    • Higurashi, T.1    Hosono, K.2    Takahashi, H.3
  • 30
    • 84904895520 scopus 로고    scopus 로고
    • Accumulating research: a systematic account of how cumulative meta-analyses would have provided knowledge, improved health, reduced harm and saved resources
    • Clarke, M., Brice, A., Chalmers, I., Accumulating research: a systematic account of how cumulative meta-analyses would have provided knowledge, improved health, reduced harm and saved resources. PLoS One, 9, 2014, e102670.
    • (2014) PLoS One , vol.9 , pp. e102670
    • Clarke, M.1    Brice, A.2    Chalmers, I.3
  • 31
    • 84875322691 scopus 로고    scopus 로고
    • The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials
    • Jones, A.P., Conroy, E., Williamson, P.R., et al. The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials. BMC Med Res Methodol, 13, 2013, 50.
    • (2013) BMC Med Res Methodol , vol.13 , pp. 50
    • Jones, A.P.1    Conroy, E.2    Williamson, P.R.3
  • 32
    • 85096698603 scopus 로고    scopus 로고
    • PROSPERO (International Prospective Register of Systematic Reviews). (January 2016, date last accessed).
    • PROSPERO (International Prospective Register of Systematic Reviews). http://www.crd.york.ac.uk/prospero/ (January 2016, date last accessed).
  • 33
    • 85096686438 scopus 로고    scopus 로고
    • GWells, BShea, DO'Connell. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
    • GWells, BShea, DO'Connell. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
  • 34
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar, M.K., Torri, V., Stewart, L., Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 17 (1998), 2815–2834.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 35
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney, J.F., Stewart, L.A., Ghersi, D., et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials, 8, 2007, 16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3
  • 36
    • 0037202566 scopus 로고    scopus 로고
    • Aggregate data meta-analysis with time-to-event outcomes
    • Williamson, P.R., Smith, C.T., Hutton, J.L., Marson, A.G., Aggregate data meta-analysis with time-to-event outcomes. Stat Med 21 (2002), 3337–3351.
    • (2002) Stat Med , vol.21 , pp. 3337-3351
    • Williamson, P.R.1    Smith, C.T.2    Hutton, J.L.3    Marson, A.G.4
  • 37
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian, R., Laird, N., Meta-analysis in clinical trials. Control Clin Trials 7 (1986), 177–188.
    • (1986) Control Clin Trials , vol.7 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 38
    • 84882273707 scopus 로고    scopus 로고
    • A cohort study of metformin exposure and survival in patients with stage I–III colorectal cancer
    • Spillane, S., Bennett, K., Sharp, L., Barron, T.I., A cohort study of metformin exposure and survival in patients with stage I–III colorectal cancer. Cancer Epidemiol Biomarkers Prev 22 (2013), 1364–1373.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 1364-1373
    • Spillane, S.1    Bennett, K.2    Sharp, L.3    Barron, T.I.4
  • 39
    • 84866323234 scopus 로고    scopus 로고
    • Examining the effects of metformin on survival outcome in stage II/III colorectal cancer patients with diabetes mellitus
    • abstr 3589
    • Lee GE, A.T., Lim, K.H., Tan, W.S., et al. Examining the effects of metformin on survival outcome in stage II/III colorectal cancer patients with diabetes mellitus. J Clin Oncol, 30, 2012 abstr 3589.
    • (2012) J Clin Oncol , vol.30
    • Lee GE, A.T.1    Lim, K.H.2    Tan, W.S.3
  • 40
    • 84861576077 scopus 로고    scopus 로고
    • The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
    • Lee, J.H., Kim, T.I., Jeon, S.M., et al. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer 131 (2012), 752–759.
    • (2012) Int J Cancer , vol.131 , pp. 752-759
    • Lee, J.H.1    Kim, T.I.2    Jeon, S.M.3
  • 41
    • 84991810214 scopus 로고    scopus 로고
    • Relationship between metformin use and recurrence and survival in patients (pts) with resected stage III colon cancer (CC) receiving adjuvant chemotherapy: Results from NCCTG N0147 (Alliance)
    • Singh, P.P., Shi, Q., Foster, N.R., et al. Relationship between metformin use and recurrence and survival in patients (pts) with resected stage III colon cancer (CC) receiving adjuvant chemotherapy: Results from NCCTG N0147 (Alliance). ASCO Meeting Abstr, 33, 2015, 3531.
    • (2015) ASCO Meeting Abstr , vol.33 , pp. 3531
    • Singh, P.P.1    Shi, Q.2    Foster, N.R.3
  • 42
    • 84938418560 scopus 로고    scopus 로고
    • Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?
    • Zanders, M.M., van Herk-Sukel, M.P., Vissers, P.A., et al. Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?. Br J Cancer 113 (2015), 403–410.
    • (2015) Br J Cancer , vol.113 , pp. 403-410
    • Zanders, M.M.1    van Herk-Sukel, M.P.2    Vissers, P.A.3
  • 43
    • 84887610935 scopus 로고    scopus 로고
    • Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
    • Allott, E.H., Abern, M.R., Gerber, L., et al. Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database. Prostate Cancer Prostatic Dis 16 (2013), 391–397.
    • (2013) Prostate Cancer Prostatic Dis , vol.16 , pp. 391-397
    • Allott, E.H.1    Abern, M.R.2    Gerber, L.3
  • 44
    • 84890791760 scopus 로고    scopus 로고
    • Effect of metformin on prostate cancer outcomes after radical prostatectomy
    • Kaushik, D., Karnes, R.J., Eisenberg, M.S., et al. Effect of metformin on prostate cancer outcomes after radical prostatectomy. Urol Oncol 32 (2014), 43.e41–43.e47.
    • (2014) Urol Oncol , vol.32 , pp. 43.e41-43.e47
    • Kaushik, D.1    Karnes, R.J.2    Eisenberg, M.S.3
  • 45
    • 84904874670 scopus 로고    scopus 로고
    • Association of diabetes mellitus and metformin use with biochemical recurrence in patients treated with radical prostatectomy for prostate cancer
    • Rieken, M., Kluth, L.A., Xylinas, E., et al. Association of diabetes mellitus and metformin use with biochemical recurrence in patients treated with radical prostatectomy for prostate cancer. World J Urol 32 (2014), 999–1005.
    • (2014) World J Urol , vol.32 , pp. 999-1005
    • Rieken, M.1    Kluth, L.A.2    Xylinas, E.3
  • 46
    • 84874538282 scopus 로고    scopus 로고
    • Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality
    • Spratt, D.E., Zhang, C., Zumsteg, Z.S., et al. Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality. Eur Urol 63 (2013), 709–716.
    • (2013) Eur Urol , vol.63 , pp. 709-716
    • Spratt, D.E.1    Zhang, C.2    Zumsteg, Z.S.3
  • 47
    • 84886557970 scopus 로고    scopus 로고
    • Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes
    • Margel, D., Urbach, D.R., Lipscombe, L.L., et al. Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes. J Clin Oncol 31 (2013), 3069–3075.
    • (2013) J Clin Oncol , vol.31 , pp. 3069-3075
    • Margel, D.1    Urbach, D.R.2    Lipscombe, L.L.3
  • 48
    • 84890642780 scopus 로고    scopus 로고
    • Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response
    • Zannella, V.E., Dal Pra, A., Muaddi, H., et al. Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response. Clin Cancer Res 19 (2013), 6741–6750.
    • (2013) Clin Cancer Res , vol.19 , pp. 6741-6750
    • Zannella, V.E.1    Dal Pra, A.2    Muaddi, H.3
  • 49
    • 84922632590 scopus 로고    scopus 로고
    • Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes
    • Danzig, M.R., Kotamarti, S., Ghandour, R.A., et al. Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes. Prostate Cancer Prostatic Dis 18 (2015), 63–68.
    • (2015) Prostate Cancer Prostatic Dis , vol.18 , pp. 63-68
    • Danzig, M.R.1    Kotamarti, S.2    Ghandour, R.A.3
  • 50
    • 84907690801 scopus 로고    scopus 로고
    • Metformin is not associated with improved biochemical free survival or cause-specific survival in men with prostate cancer treated with permanent interstitial brachytherapy
    • Taira, A.V., Merrick, G.S., Galbreath, R.W., et al. Metformin is not associated with improved biochemical free survival or cause-specific survival in men with prostate cancer treated with permanent interstitial brachytherapy. J Contemp Brachytherapy 6 (2014), 254–261.
    • (2014) J Contemp Brachytherapy , vol.6 , pp. 254-261
    • Taira, A.V.1    Merrick, G.S.2    Galbreath, R.W.3
  • 51
    • 84925389870 scopus 로고    scopus 로고
    • The effect of metformin on breast cancer outcomes in patients with type 2 diabetes
    • Oppong, B.A., Pharmer, L.A., Oskar, S., et al. The effect of metformin on breast cancer outcomes in patients with type 2 diabetes. Cancer Med 3 (2014), 1025–1034.
    • (2014) Cancer Med , vol.3 , pp. 1025-1034
    • Oppong, B.A.1    Pharmer, L.A.2    Oskar, S.3
  • 52
    • 84857372409 scopus 로고    scopus 로고
    • Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer
    • Bayraktar, S., Hernadez-Aya, L.F., Lei, X., et al. Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer 118 (2012), 1202–1211.
    • (2012) Cancer , vol.118 , pp. 1202-1211
    • Bayraktar, S.1    Hernadez-Aya, L.F.2    Lei, X.3
  • 53
    • 84883527299 scopus 로고    scopus 로고
    • Association between metformin therapy and mortality after breast cancer: a population-based study
    • Lega, I.C., Austin, P.C., Gruneir, A., et al. Association between metformin therapy and mortality after breast cancer: a population-based study. Diabetes Care 36 (2013), 3018–3026.
    • (2013) Diabetes Care , vol.36 , pp. 3018-3026
    • Lega, I.C.1    Austin, P.C.2    Gruneir, A.3
  • 54
    • 84887263940 scopus 로고    scopus 로고
    • Association of diabetes mellitus and metformin use with oncological outcomes of patients with non-muscle-invasive bladder cancer
    • Rieken, M., Xylinas, E., Kluth, L., et al. Association of diabetes mellitus and metformin use with oncological outcomes of patients with non-muscle-invasive bladder cancer. BJU Int 112 (2013), 1105–1112.
    • (2013) BJU Int , vol.112 , pp. 1105-1112
    • Rieken, M.1    Xylinas, E.2    Kluth, L.3
  • 55
    • 84890786945 scopus 로고    scopus 로고
    • Effect of diabetes mellitus and metformin use on oncologic outcomes of patients treated with radical cystectomy for urothelial carcinoma
    • Rieken, M., Xylinas, E., Kluth, L., et al. Effect of diabetes mellitus and metformin use on oncologic outcomes of patients treated with radical cystectomy for urothelial carcinoma. Urol Oncol 32 (2014), 49.e7–49.e14.
    • (2014) Urol Oncol , vol.32 , pp. 49.e7-49.e14
    • Rieken, M.1    Xylinas, E.2    Kluth, L.3
  • 56
    • 84892526938 scopus 로고    scopus 로고
    • Diabetes mellitus without metformin intake is associated with worse oncologic outcomes after radical nephroureterectomy for upper tract urothelial carcinoma
    • Rieken, M., Xylinas, E., Kluth, L., et al. Diabetes mellitus without metformin intake is associated with worse oncologic outcomes after radical nephroureterectomy for upper tract urothelial carcinoma. Eur J Surg Oncol 40 (2014), 113–120.
    • (2014) Eur J Surg Oncol , vol.40 , pp. 113-120
    • Rieken, M.1    Xylinas, E.2    Kluth, L.3
  • 57
    • 84929086892 scopus 로고    scopus 로고
    • Effect of metformin on progression of head and neck cancers, occurrence of second primary cancers, and cause-specific survival
    • Kwon, M., Roh, J.L., Song, J., et al. Effect of metformin on progression of head and neck cancers, occurrence of second primary cancers, and cause-specific survival. Oncologist 20 (2015), 546–553.
    • (2015) Oncologist , vol.20 , pp. 546-553
    • Kwon, M.1    Roh, J.L.2    Song, J.3
  • 58
    • 85096698056 scopus 로고    scopus 로고
    • An analysis of the potential benefits of metformin on disease recurrence in oral and oropharyngeal squamous cell carcinoma
    • Thompson, C., Wang, M., Sanaiha, Y., et al. An analysis of the potential benefits of metformin on disease recurrence in oral and oropharyngeal squamous cell carcinoma. J Cancer Ther 4 (2013), 961–965.
    • (2013) J Cancer Ther , vol.4 , pp. 961-965
    • Thompson, C.1    Wang, M.2    Sanaiha, Y.3
  • 59
    • 84887349816 scopus 로고    scopus 로고
    • The impact of metformin use on recurrence and cancer-specific survival in clinically localized high-risk renal cell carcinoma
    • Hakimi, A.A., Chen, L., Kim, P.H., et al. The impact of metformin use on recurrence and cancer-specific survival in clinically localized high-risk renal cell carcinoma. Can Urol Assoc J 7 (2013), E687–E691.
    • (2013) Can Urol Assoc J , vol.7 , pp. E687-E691
    • Hakimi, A.A.1    Chen, L.2    Kim, P.H.3
  • 60
    • 84923600700 scopus 로고    scopus 로고
    • The association between metformin use and oncologic outcomes among surgically treated diabetic patients with localized renal cell carcinoma
    • Psutka, S.P., Boorjian, S.A., Lohse, C.M., et al. The association between metformin use and oncologic outcomes among surgically treated diabetic patients with localized renal cell carcinoma. Urol Oncol 33 (2015), 67e15–67e23.
    • (2015) Urol Oncol , vol.33 , pp. 67e15-67e23
    • Psutka, S.P.1    Boorjian, S.A.2    Lohse, C.M.3
  • 61
    • 84979688557 scopus 로고    scopus 로고
    • Effect of metformin use on the survival outcomes in diabetic patients with resectable pancreatic cancer: a single-institutional experience and meta-analysis
    • Ambe, C., Mahipal, A., Fulp, W.J., et al. Effect of metformin use on the survival outcomes in diabetic patients with resectable pancreatic cancer: a single-institutional experience and meta-analysis. ASCO Meeting Abstr, 33, 2015, 465.
    • (2015) ASCO Meeting Abstr , vol.33 , pp. 465
    • Ambe, C.1    Mahipal, A.2    Fulp, W.J.3
  • 62
    • 85044202481 scopus 로고    scopus 로고
    • Association between metformin (M) use and survival among non-small cell lung cancer (NSCLC) patients (pts)
    • Fortune-Greeley, A.K., Williams, C.D., Paulus, J.K., Kelley, M.J., Association between metformin (M) use and survival among non-small cell lung cancer (NSCLC) patients (pts). ASCO Meeting Abstr, 32, 2014, 7568.
    • (2014) ASCO Meeting Abstr , vol.32 , pp. 7568
    • Fortune-Greeley, A.K.1    Williams, C.D.2    Paulus, J.K.3    Kelley, M.J.4
  • 63
    • 84894041491 scopus 로고    scopus 로고
    • Metformin is associated with improved survival in endometrial cancer
    • Ko, E.M., Walter, P., Jackson, A., et al. Metformin is associated with improved survival in endometrial cancer. Gynecol Oncol 132 (2014), 438–442.
    • (2014) Gynecol Oncol , vol.132 , pp. 438-442
    • Ko, E.M.1    Walter, P.2    Jackson, A.3
  • 64
    • 84953839826 scopus 로고    scopus 로고
    • Cumulative metformin use and its impact on survival in gastric cancer patients after gastrectomy
    • Lee, C.K., Jung, M., Jung, I., et al. Cumulative metformin use and its impact on survival in gastric cancer patients after gastrectomy. Ann Surg 263 (2016), 96–102.
    • (2016) Ann Surg , vol.263 , pp. 96-102
    • Lee, C.K.1    Jung, M.2    Jung, I.3
  • 65
  • 66
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti, K.G., Eckel, R.H., Grundy, S.M., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120 (2009), 1640–1645.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 67
    • 40349105880 scopus 로고    scopus 로고
    • Metabolic syndrome, hyperinsulinemia, and colon cancer: a review
    • Giovannucci, E., Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 86 (2007), s836–s842.
    • (2007) Am J Clin Nutr , vol.86 , pp. s836-s842
    • Giovannucci, E.1
  • 68
    • 77955470226 scopus 로고    scopus 로고
    • Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis
    • Shen, Z., Ye, Y., Bin, L., et al. Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis. Am J Surg 200 (2010), 59–63.
    • (2010) Am J Surg , vol.200 , pp. 59-63
    • Shen, Z.1    Ye, Y.2    Bin, L.3
  • 69
    • 84925845413 scopus 로고    scopus 로고
    • Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis
    • Bosco, C., Crawley, D., Adolfsson, J., et al. Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis. PLoS One, 10, 2015, e0117344.
    • (2015) PLoS One , vol.10 , pp. e0117344
    • Bosco, C.1    Crawley, D.2    Adolfsson, J.3
  • 70
    • 79960346497 scopus 로고    scopus 로고
    • AMPK regulates metabolism and survival in response to ionizing radiation
    • Zannella, V.E., Cojocari, D., Hilgendorf, S., et al. AMPK regulates metabolism and survival in response to ionizing radiation. Radiother Oncol 99 (2011), 293–299.
    • (2011) Radiother Oncol , vol.99 , pp. 293-299
    • Zannella, V.E.1    Cojocari, D.2    Hilgendorf, S.3
  • 71
    • 84890642780 scopus 로고    scopus 로고
    • Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response
    • Zannella, V.E., Pra, A.D., Muaddi, H., et al. Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response. Clin Cancer Res 19 (2013), 6741–6750.
    • (2013) Clin Cancer Res , vol.19 , pp. 6741-6750
    • Zannella, V.E.1    Pra, A.D.2    Muaddi, H.3
  • 72
    • 84869788946 scopus 로고    scopus 로고
    • Metformin and the risk of cancer: time-related biases in observational studies
    • Suissa, S., Azoulay, L., Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care 35 (2012), 2665–2673.
    • (2012) Diabetes Care , vol.35 , pp. 2665-2673
    • Suissa, S.1    Azoulay, L.2
  • 73
    • 83955161674 scopus 로고    scopus 로고
    • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    • Burn, J., Gerdes, A.M., Macrae, F., et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 378 (2011), 2081–2087.
    • (2011) Lancet , vol.378 , pp. 2081-2087
    • Burn, J.1    Gerdes, A.M.2    Macrae, F.3
  • 74
    • 84880278340 scopus 로고    scopus 로고
    • Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial
    • Cook, N.R., Lee, I.M., Zhang, S.M., et al. Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial. Ann Intern Med 159 (2013), 77–85.
    • (2013) Ann Intern Med , vol.159 , pp. 77-85
    • Cook, N.R.1    Lee, I.M.2    Zhang, S.M.3
  • 75
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    • Rothwell, P.M., Wilson, M., Elwin, C.E., et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376 (2010), 1741–1750.
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elwin, C.E.3
  • 76
    • 84873542894 scopus 로고    scopus 로고
    • Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer
    • Jeon, J.Y., Jeong, D.H., Park, M.G., et al. Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. PLoS One, 8, 2013, e55196.
    • (2013) PLoS One , vol.8 , pp. e55196
    • Jeon, J.Y.1    Jeong, D.H.2    Park, M.G.3
  • 77
    • 84873414482 scopus 로고    scopus 로고
    • Diabetes mellitus is associated with short prostate-specific antigen doubling time after radical prostatectomy
    • Oh, J.J., Hong, S.K., Lee, S., et al. Diabetes mellitus is associated with short prostate-specific antigen doubling time after radical prostatectomy. Int Urol Nephrol 45 (2013), 121–127.
    • (2013) Int Urol Nephrol , vol.45 , pp. 121-127
    • Oh, J.J.1    Hong, S.K.2    Lee, S.3
  • 78
    • 77953539812 scopus 로고    scopus 로고
    • Long-term metformin use is associated with decreased risk of breast cancer
    • Bodmer, M., Meier, C., Krahenbuhl, S., et al. Long-term metformin use is associated with decreased risk of breast cancer. Diabetes Care 33 (2010), 1304–1308.
    • (2010) Diabetes Care , vol.33 , pp. 1304-1308
    • Bodmer, M.1    Meier, C.2    Krahenbuhl, S.3
  • 79
    • 84866548333 scopus 로고    scopus 로고
    • Metformin and breast cancer risk: a meta-analysis and critical literature review
    • Col, N.F., Ochs, L., Springmann, V., et al. Metformin and breast cancer risk: a meta-analysis and critical literature review. Breast Cancer Res Treat 135 (2012), 639–646.
    • (2012) Breast Cancer Res Treat , vol.135 , pp. 639-646
    • Col, N.F.1    Ochs, L.2    Springmann, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.