Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Nature communications

Volumn 7, Issue , 2016, Pages 11384-

  Brooun, Alexei ^a   Gajiwala, Ketan S ^a   Deng, Ya Li ^a   Liu, Wei ^a   Bolaños, Ben ^a   Bingham, Patrick ^a   He, You Ai ^a   Diehl, Wade ^a   Grable, Nicole ^a   Kung, Pei Pei ^a   Sutton, Scott ^a   Maegley, Karen A ^a   Yu, Xiu ^a   Stewart, Al E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EZH2 PROTEIN, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG RESISTANCE; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; NEOPLASM;

ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MUTATION; NEOPLASMS; POLYCOMB REPRESSIVE COMPLEX 2;

EID: 85000543831     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11384     Document Type: Article

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