Improving T Cell Expansion with a Soft Touch

Nano Letters

Volumn 17, Issue 2, 2017, Pages 821-826

  Lambert, Lester H ^a   Goebrecht, Geraldine K E ^a   De Leo, Sarah E ^a   O'Connor, Roddy S ^b   Nunez Cruz, Selene ^b   Li, Tai De ^c   Yuan, Jinglun ^a   Milone, Michael C ^b   Kam, Lance C ^a  

^a Department of Earth and Environmental Sciences   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

immunotherapy; mechanobiology; nanoscale rigidity; T cell

Indexed keywords

CELLS; CHEMICAL ACTIVATION; CYTOLOGY; MICROCHANNELS; NANOTECHNOLOGY; POLYDIMETHYLSILOXANE; RIGIDITY; SILICONES;

ANTIGEN PRESENTING CELLS; CELL PREPARATION; CURING CONDITION; IMMUNOTHERAPY; MECHANO-BIOLOGY; NANO SCALE; POLYDIMETHYLSILOXANE PDMS; POLYMER STRUCTURE;

T-CELLS;

ANTIBODY; BAYSILON; CD28 ANTIGEN; CD3 ANTIGEN; DIMETICONE; MICROSPHERE;

CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; EMULSION; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; PARTICLE SIZE; PHYSIOLOGY; SURFACE PROPERTY; T LYMPHOCYTE;

ANTIBODIES; CD28 ANTIGENS; CD3 COMPLEX; CELL PROLIFERATION; CELL SURVIVAL; DIMETHYLPOLYSILOXANES; EMULSIONS; HUMANS; IMMUNOTHERAPY; MICROSPHERES; PARTICLE SIZE; SURFACE PROPERTIES; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 85012013191     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/acs.nanolett.6b04071     Document Type: Article

References (21)

1. Ratta, M.; Fagnoni, F.; Curti, A.; Vescovini, R.; Sansoni, P.; Oliviero, B.; Fogli, M.; Ferri, E.; Della Cuna, G. R.; Tura, S.; Baccarani, M.; Lemoli, R. M. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6 Blood 2002, 100, 230-237
2. Ruffini, P. A.; Kwak, L. W. Immunotherapy of multiple myeloma Semin. Hematol. 2001, 38, 260-267 10.1016/S0037-1963(01)90018-6
3. Zheng, C. Y.; Ostad, M.; Andersson, M.; Celsing, F.; Holm, G.; Sundblad, A. Natural cytotoxicity to autologous antigen-pulsed dendritic cells in multiple myeloma Br. J. Haematol. 2002, 118, 778-785 10.1046/j.1365-2141.2002.03712.x
4. Della Bella, S.; Gennaro, M.; Vaccari, M.; Ferraris, C.; Nicola, S.; Riva, A.; Clerici, M.; Greco, M.; Villa, M. L. Altered maturation of peripheral blood dendritic cells in patients with breast cancer Br. J. Cancer 2003, 89, 1463-1472 10.1038/sj.bjc.6601243
5. Oelke, M.; Krueger, C.; Jonathan, P. Technological advances in adoptive immunotherapy Drugs Today 2005, 41, 13-21 10.1358/dot.2005.41.1.875775
6. Andres, P. G.; Howland, K. C.; Dresnek, D.; Edmondson, S.; Abbas, A. K.; Krummel, M. F. CD28 Signals in the Immature Immunological Synapse J. Immunol. 2004, 172, 5880-5886 10.4049/jimmunol.172.10.5880
7. Turtle, C. J.; Delrow, J.; Joslyn, R. C.; Swanson, H. M.; Basom, R.; Tabellini, L.; Delaney, C.; Heimfeld, S.; Hansen, J. A.; Riddell, S. R. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8alpha(+) semi-invariant T cells Blood 2011, 118, 2752-62 10.1182/blood-2011-02-334698
8. Eggermont, L. J.; Paulis, L. E.; Tel, J.; Figdor, C. G. Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells Trends Biotechnol. 2014, 32, 456-65 10.1016/j.tibtech.2014.06.007
9. O'Connor, R. S.; Hao, X.; Shen, K.; Bashour, K.; Akimova, T.; Hancock, W. W.; Kam, L. C.; Milone, M. C. Substrate Rigidity Regulates Human T Cell Activation and Proliferation J. Immunol. 2012, 189, 1330-9 10.4049/jimmunol.1102757
10. Eteshola, E.; Leckband, D. Development and characterization of an ELISA assay in PDMS microfluidic channels Sens. Actuators, B 2001, 72, 129-133 10.1016/S0925-4005(00)00640-7
11. Mescher, M. F. Surface contact requirements for activation of cytotoxic T lymphocytes J. Immunol. 1992, 149, 2402-5
12. Wei, X.; Tromberg, B. J.; Cahalan, M. D. Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signaling Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 8471-6 10.1073/pnas.96.15.8471
13. Hu, J.; Gondarenko, A. A.; Dang, A. P.; Bashour, K. T.; O'Connor, R. S.; Lee, S.; Liapis, A.; Ghassemi, S.; Milone, M. C.; Sheetz, M. P.; Dustin, M. L.; Kam, L. C.; Hone, J. C. High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography Nano Lett. 2016, 16, 2198-204 10.1021/acs.nanolett.5b04364
14. Kwon, K. W.; Park, H.; Doh, J. Migration of T cells on surfaces containing complex nanotopography PLoS One 2013, 8, e73960 10.1371/journal.pone.0073960
15. Milone, M. C.; Fish, J. D.; Carpenito, C.; Carroll, R. G.; Binder, G. K.; Teachey, D.; Samanta, M.; Lakhal, M.; Gloss, B.; Danet-Desnoyers, G.; Campana, D.; Riley, J. L.; Grupp, S. A.; June, C. H. June, C. H., Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo Mol. Ther. 2009, 17, 1453-1464 10.1038/mt.2009.83
16. Semnani, R. T.; Keiser, P. B.; Coulibaly, Y. I.; Keita, F.; Diallo, A. A.; Traore, D.; Diallo, D. A.; Doumbo, O. K.; Traore, S. F.; Kubofcik, J.; Klion, A. D.; Nutman, T. B. Filaria-induced monocyte dysfunction and its reversal following treatment Infect. Immun. 2006, 74, 4409-17 10.1128/IAI.01106-05
17. Levental, I.; Georges, P. C.; Janmey, P. A. Soft biological materials and their impact on cell function Soft Matter 2007, 3, 299-306 10.1039/B610522J
18. Miyaji, K.; Furuse, A.; Nakajima, J.; Kohno, T.; Ohtsuka, T.; Yagyu, K.; Oka, T.; Omata, S. The stiffness of lymph nodes containing lung carcinoma metastases: a new diagnostic parameter measured by a tactile sensor Cancer 1997, 80, 1920-5 10.1002/(SICI)1097-0142(19971115)80:10<1920::AID-CNCR8>3.0.CO;2-R
19. Smoligovets, A. A.; Smith, A. W.; Wu, H. J.; Petit, R. S.; Groves, J. T. Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells J. Cell Sci. 2012, 125, 735-42 10.1242/jcs.092825
20. Yu, C.-h.; Wu, H.-J.; Kaizuka, Y.; Vale, R. D.; Groves, J. T. Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses PLoS One 2010, 5, e11878 10.1371/journal.pone.0011878
21. Bangasser, B. L.; Rosenfeld, S. S.; Odde, D. J. Determinants of maximal force transmission in a motor-clutch model of cell traction in a compliant microenvironment Biophys. J. 2013, 105, 581-92 10.1016/j.bpj.2013.06.027