Kamikihito ameliorates lipopolysaccharide-induced sickness behavior via attenuating neural activation, but not inflammation, in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice

Biological and Pharmaceutical Bulletin

Volumn 39, Issue 2, 2016, Pages 289-294

  Araki, Ryota ^a   Nishida, Shoji ^a   Hiraki, Yosuke ^a   Li, Feng ^b   Matsumoto, Kinzo ^b   Yabe, Takeshi ^a  

^a SETSUNAN UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Amygdala; Hypothalamus; Kamikihito; Lipopolysaccharide; Sickness behavior

Indexed keywords

CYCLOOXYGENASE 2; ENDOTOXIN; HERBACEOUS AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAMIKIHITO; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN C FOS; UNCLASSIFIED DRUG; KAMIKIHI-TO;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NUCLEUS (AMYGDALA); DEPRESSION; DRUG ACTIVITY; EMOTIONALITY; EXPLORATORY BEHAVIOR; GENE EXPRESSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ILLNESS BEHAVIOR; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NERVOUS SYSTEM PARAMETERS; NEURAL ACTIVATION; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SOCIAL INTERACTION; ANIMAL; ANIMAL BEHAVIOR; CYTOLOGY; DRUG EFFECTS; NERVE CELL; PHYSIOLOGY;

ANIMALS; BEHAVIOR, ANIMAL; CENTRAL AMYGDALOID NUCLEUS; DRUGS, CHINESE HERBAL; ILLNESS BEHAVIOR; LIPOPOLYSACCHARIDES; MALE; MICE; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS;

EID: 85011915690     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/BPB.B15-00707     Document Type: Article

References (29)

1. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci., 9, 46-56 (2008).
2. DellaGioia N, Hannestad J. A critical review of human endotoxin administration as an experimental paradigm of depression. Neurosci. Biobehav. Rev., 34, 130-143 (2010).
3. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am. J. Psychiatry, 157, 683-694 (2000).
4. Bluthé RM, Dantzer R, Kelley KW. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res., 573, 318-320 (1992).
5. Yirmiya R, Tio DL, Taylor AN. Effects of fetal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-1 beta in young adult rats. Brain Behav. Immun., 10, 205-220 (1996).
6. Swiergiel AH, Smagin GN, Johnson LJ, Dunn AJ. The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra). Brain Res., 776, 96-104 (1997).
7. Bluthé RM, Castanon N, Pousset F, Bristow A, Ball C, Lestage J, Michaud B, Kelley KW, Dantzer R. Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Psychoneuroendocrinology, 24, 301-311 (1999).
8. Bluthé RM, Laye S, Michaud B, Combe C, Dantzer R, Parnet P. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur. J. Neurosci., 12, 4447-4456 (2000).
9. Bluthé RM, Michaud B, Poli V, Dantzer R. Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice. Physiol. Behav., 70, 367-373 (2000).
10. Dunn AJ, Swiergiel AH. Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice. Pharmacol. Biochem. Behav., 81, 688-693 (2005).
11. Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J, Kelley KW, Dantzer R, Castanon N. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology, 32, 516-531 (2007).
12. Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP. Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J. Neuroinflammation, 5, 15 (2008).
13. de Paiva VN, Lima SN, Fernandes MM, Soncini R, Andrade CA, Giusti-Paiva A. Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behav. Brain Res., 215, 146-151 (2010).
14. Haba R, Shintani N, Onaka Y, Wang H, Takenaga R, Hayata A, Baba A, Hashimoto H. Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala. Behav. Brain Res., 228, 423-431 (2012).
15. Araki R, Hiraki Y, Yabe T. Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behaviors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus. Eur. J. Pharmacol., 741, 1-7 (2014).
16. Nishizawa K, Saito H, Nishiyama N. Effects of Kamikihi-to, a traditional Chinese medicine, on passive and conditioned avoidance performance impairment in senescence accelerated mouse (SAM). Jpn. J. Pharmacol., 54, 375-382 (1990).
17. Shimamura M, Nishizawa K, Yamashita A. Effects of Kamikihi-to on ovariectomy-induced changes in behavior and circulation in rats. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, 108, 65-75 (1996).
18. Nishizawa K, Yamashita A. Effects of Kamikihi-to, a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate in mice and rats. Jpn. J. Pharmacol., 75, 391-397 (1997).
19. Egashira N, Manome N, Kurauchi K, Matsumoto Y, Iwasaki K, Mishima K, Shoyama Y, Fujiwara M. Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats. Phytotherapy Research: PTR, 21, 126-129 (2007).
20. Tohda C, Nakada R, Urano T, Okonogi A, Kuboyama T. Kamikihito (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD. Int. J. Neurosci., 121, 641-648 (2011).
21. Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Methods, 29, 261-265 (1989).
22. Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata KY, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 34, 2514-2523 (2014).
23. Araki R, Nishida S, Hiraki Y, Yabe T. Kamikihito ameliorates tumor-induced sickness behavior in mice. Traditional & Kampo Medicine, 2, 93-96 (2015).
24. Kent S, Bluthe RM, Dantzer R, Hardwick AJ, Kelley KW, Rothwell NJ, Vannice JL. Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc. Natl. Acad. Sci. U.S.A., 89, 9117-9120 (1992).
25. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci., 3, 216-227 (2002).
26. Naoi K, Kogure S, Saito M, Hamazaki T, Watanabe S. Differential effects of selective cyclooxygenase (COX)-1 and COX-2 inhibitors on anorexic response and prostaglandin generation in various tissues induced by zymosan. Biol. Pharm. Bull., 29, 1319-1324 (2006).
27. Pecchi E, Dallaporta M, Jean A, Thirion S, Troadec JD. mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice. J. Neuroimmunol., 199, 104-114 (2008).
28. Konsman JP, Luheshi GN, Bluthé RM, Dantzer R. The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur. J. Neurosci., 12, 4434-4446 (2000).
29. Marvel FA, Chen CC, Badr N, Gaykema RP, Goehler LE. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain Behav. Immun., 18, 123-134 (2004).