Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model

Journal of Dental Research

Volumn 96, Issue 3, 2017, Pages 315-322

  Tamasas, B ^a,b   Cox, T C ^a,b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

craniofacial biology genetics; dental caries susceptibility; mucosal immunity; orofacial cleft(s); periodontal disease periodontitis; salivary antimicrobial proteins

Indexed keywords

CCL27 PROTEIN, MOUSE; CUTANEOUS T CELL ATTRACTING CHEMOKINE; INTERFERON REGULATORY FACTOR; IRF6 PROTEIN, MOUSE;

ANIMAL; CELL PROLIFERATION; CLEFT LIP; CLEFT PALATE; DENTAL CARIES; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; IMMUNOLOGY; MICROBIOLOGY; MOUSE; MUCOSAL IMMUNITY; PATHOLOGY; PH; PHENOTYPE; SALIVARY GLAND; SALIVATION;

ANIMALS; CELL PROLIFERATION; CHEMOKINE CCL27; CLEFT LIP; CLEFT PALATE; DENTAL CARIES; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HYDROGEN-ION CONCENTRATION; IMMUNITY, MUCOSAL; INTERFERON REGULATORY FACTORS; MICE; PHENOTYPE; SALIVARY GLANDS; SALIVATION;

EID: 85011842209     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034516679376     Document Type: Article

References (38)

1. Ahluwalia M, Brailsford SR, Tarelli E, Gilbert SC, Clark DT, Barnard K, Beighton D,. 2004. Dental caries, oral hygiene, and oral clearance in children with craniofacial disorders. J Dent Res. 83 (2): 175-179.
2. Aizenbud D, Peri-Front Y, Nagler RM,. 2008. Salivary analysis and antioxidants in cleft lip and palate children. Arch Oral Biol. 53 (6): 517-522.
3. Antonarakis GS, Palaska PK, Herzog G,. 2013. Caries prevalence in non-syndromic patients with cleft lip and/or palate: a meta-analysis. Caries Res. 47 (5): 406-413.
4. Catalán MA, Scott-Anne K, Klein MI, Koo H, Bowen WH, Melvin JE,. 2011. Elevated incidence of dental caries in a mouse model of cystic fibrosis. PLoS One. 6 (1): e16549.
5. Chu EY, Tamasas B, Fong H, Foster BL, LaCourse MR, Tran AB, Martin JF, Schutte BC, Somerman MJ, Cox TC,. 2016. Full spectrum of postnatal tooth phenotypes in a novel Irf6 cleft lip model. J Dent Res. 95 (11): 1265-1273.
6. Culp DJ, Quivey RQ, Bowen WH, Fallon MA, Pearson SK, Faustoferri R,. 2005. A mouse caries model and evaluation of Aqp5 -/- knockout mice. Caries Res. 39 (6): 448-454.
7. Dahllöf G, Ussisoo-Joandi R, Ideberg M, Modeer T,. 1989. Caries, gingivitis, and dental abnormalities in preschool children with cleft lip and/or palate. Cleft Palate J. 26 (3): 233-237.
8. Dixon MJ, Marazita ML, Beaty TH, Murray JC,. 2011. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 12 (3): 167-178.
9. Ericson D, Bratthall D,. 1989. Simplified method to estimate salivary buffer capacity. Scand J Dent Res. 97 (5): 405-407.
10. Fakhouri WD, Rhea L, Du T, Sweezer E, Morrison H, Fitzpatrick D, Yang B, Dunnwald M, Schutte BC,. 2012. MCS9.7 enhancer activity is highly, but not completely, associated with expression of Irf6 and p63. Dev Dyn. 241 (2): 340-349.
11. Hicks J, Garcia-Godoy F, Flaitz C,. 2003. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent. 28 (1): 47-52.
12. Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, Shiba F, Shiota M, Katou F, Saito T, et al. 2003. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol. 170 (3): 1452-1461.
13. Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ, Malik MI, Dunnwald M, Goudy SL, Lovett M, et al. 2006. Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat Genet. 38 (11): 1335-1340.
14. Ishibashi K, Hara S, Kondo S,. 2009. Aquaporin water channels in mammals. Clin Exp Nephrol. 13 (2): 107-117.
15. Jindal A, McMeans M, Narayanan S, Rose EK, Jain S, Marazita ML, Menezes R, Letra A, Carvalho FM, Brandon CA, et al. 2011. Women are more susceptible to caries but individuals born with clefts are not. Int J Dent. 2011: 454532.
16. Jugessur A, Farlie PG, Kilpatrick N,. 2009. The genetics of isolated orofacial clefts: from genotypes to subphenotypes. Oral Dis. 15 (7): 437-453.
17. Keyes PH,. 1958. Dental caries in the molar teeth of rats: II. A method for diagnosing and scoring several types of lesions simultaneously. J Dent Res. 37 (6): 1088-1099.
18. Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y, Howard E, de Lima RL, Daack-Hirsch S, Sander A, et al. 2002. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet. 32 (2): 285-289.
19. Larsen HS, Aure MH, Peters SB, Larsen M, Messelt EB, Kanli Galtung H,. 2011. Localization of AQP5 during development of the mouse submandibular salivary gland. J Mol Histol. 42 (1): 71-81.
20. Laugel-Haushalter V, Langer A, Marrie J, Fraulob V, Schuhbaur B, Koch-Phillips M, Dollé P, Bloch-Zupan A,. 2012. From the transcription of genes involved in ectodermal dysplasias to the understanding of associated dental anomalies. Mol Syndromol. 3 (4): 158-168.
21. Leone CW, Oppenheim FG,. 2001. Physical and chemical aspects of saliva as indicators of risk for dental caries in humans. J Dent Educ. 65 (10): 1054-1062.
22. Lin YT, Tsai CL,. 1999. Caries prevalence and bottle-feeding practices in 2-year-old children with cleft lip, cleft palate, or both in Taiwan. Cleft Palate Craniofac J. 36 (6): 522-526.
23. Michalek SM, McGhee JR, Babb JL,. 1978. Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infect Immun. 19 (1): 217-224.
24. Parada-Sanchez MT,. 2012. Dissecting the role of the major cleft gene, IRF6, in primary palatal epithelia [dissertation]. [ Seattle (WA) ]: University of Washington.
25. Phattarataratip E, Olson B, Broffitt B, Qian F, Brogden KA, Drake DR, Levy SM, Banas JA,. 2011. Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides. Mol Oral Microbiol. 26 (3): 187-199.
26. Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP, Shore P, Whitmarsh A, Dixon MJ,. 2006. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet. 38 (11): 1329-1334.
27. Shashni R, Goyal A, Gauba K, Utreja AK, Ray P, Jena AK,. 2015. Comparison of risk indicators of dental caries in children with and without cleft lip and palate deformities. Contemp Clin Dent. 6 (1): 58-62.
28. Souto LR,. 2008. Congenital bilateral lower lip pits associated with fistulae of the minor salivary glands: case report of the principal Van der Woude syndrome's trait. Aesthetic Plast Surg. 32 (1): 172-174.
29. Stockinger A, Eger A, Wolf J, Beug H, Foisner R,. 2001. E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol. 154 (6): 1185-1196.
30. Stookey GK,. 2008. The effect of saliva on dental caries. J Am Dent Assoc. 139: 11S-17S.
31. Sundell AL, Ullbro C, Marcusson A, Twetman S,. 2015. Comparing caries risk profiles between 5- and 10-year-old children with cleft lip and/or palate and non-cleft controls. BMC Oral Health. 15: 85.
32. Szabo GT, Tihanyi R, Csulak F, Jambor E, Bona A, Szabo G, Mark L,. 2012. Comparative salivary proteomics of cleft palate patients. Cleft Palate Craniofac J. 49 (5): 519-523.
33. Tannure PN, Costa Mde C, Küchler EC, Romanos HF, Granjeiro JM, Vieira AR,. 2012. Caries experience in individuals with cleft lip and palate. Pediatr Dent. 34 (2): 127-131.
34. Vieira AR, Gibson CW, Deeley K, Xue H, Li Y,. 2015. Weaker dental enamel explains dental decay. PLoS One. 10 (4): e0124236.
35. Walker JL, Menko AS, Khalil S, Rebustini I, Hoffman MP, Kreidberg JA, Kukuruzinska MA,. 2008. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 237 (11): 3128-3141.
36. Walker SC, Mattick CR, Hobson RS, Steen IN,. 2009. Abnormal tooth size and morphology in subjects with cleft lip and/or palate in the north of England. Eur J Orthod. 31 (1): 68-75.
37. Wells M,. 2014. Review suggests that cleft lip and palate patients have more caries. Evid Based Dent. 15 (3): 79.
38. Zucchero TM, Cooper ME, Maher BS, Daack-Hirsch S, Nepomuceno B, Ribeiro L, Caprau D, Christensen K, Suzuki Y, Machida J, et al. 2004. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med. 351 (8): 769-780.