CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity

Journal of Immunology

Volumn 170, Issue 3, 2003, Pages 1452-1461

  Hieshima, Kunio ^a   Ohtani, Haruo ^b,e   Shibano, Michiko ^a   Izawa, Dai ^a   Nakayama, Takashi ^a   Kawasaki, Yuri ^a   Shiba, Fumio ^a   Shiota, Mitsuru ^a   Katou, Fuminori ^c   Saito, Takuya ^d   Yoshie, Osamu ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d KINKI UNIVERSITY   (Japan)

^e National Mito Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CCL28 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR3; HISTATIN; HISTIDINE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BODY FLUID; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; CELL STRUCTURE; CHEMOTAXIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN TISSUE; MEMBRANE PERMEABILITY; MILK; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVA; SIGNAL TRANSDUCTION;

EID: 0037310861     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.3.1452     Document Type: Article

References (36)

1. Yoshie. O., T. Imai, and H. Nomiyama. 2001. Chemokines in immunity. Adv. Immunol. 78:57.
2. Zlotnik, A., and O. Yoshie. 2000. Chemokines: a new classification system and their role in immunity. Immunity 12:121.
3. Pan, J., E. J. Kunkel, U. Gosslar, N. Lazarus, P. Langdon, K. Broadwell, M.A. Vierra, M. C. Genovese, E. C. Butcher, and D. Soler. 2000. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J. Immunol. 165:2943.
4. Wang, W., H. Soto, E. R. Oldham, M. E. Buchanan, B. Homey, D. Catron, N. Jenkins, N. G. Copeland, D. J. Gilbert, N. Nguyen, et al. 2000. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275:22313.
5. Homey, B., W. Wang, H. Soto, M. E. Buchanan, A. Wiesenborn, D. Catron, A. Muller, T. K. McClanahan, M. C. Dieu-Nosjean, R. Orozco, et al. 2000. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465.
6. Jarmin, D. I., M. Rits, D. Bota, N. P. Gerard, G. J. Graham, I. Clark-Lewis, and C. Gerard. 2000. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine, J. Immunol. 164:3460.
7. Morales, J., B. Homey, A. P. Vicari, S. Hudak, E. Oldham, J. Hedrick, R. Orozco, N. G. Copeland, N. A. Jenkins, L. M. McEvoy, and A. Zlotnik. 1999. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. USA 96:14470.
8. Ishikawa-Mochizuki, I., M. Kitaura, M. Baba, T. Nakayama, D. Izawa, T. Imai, H. Yamada, K. Hieshima, R. Suzuki, H. Nomiyama, and O. Yoshie. 1999, Molecular cloning of a novel CC chemokine, interleukin-11 receptor α-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by Molluscum contagiosum virus. FEBS Lett. 460:544.
9. Ganz, T., and R. I. Lehrer. 1994. Defensins. Curr. Opin. Immunol. 6:584.
10. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389.
11. Yang, D., A. Biragyn, L. W. Kwak, and J. J. Oppenheim, 2002. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol. 23:291.
12. Territo, M. C., T. Ganz, M. E. Selsted, and R. Lehrer. 1989. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 84:2017.
13. Chertov, O., D. F. Michiel, L. Xu, J. M. Wang, K. Tani, W. J. Murphy, D. L. Longo, D. D. Taub, and J. J. Oppenheim. 1996. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 271:2935.
14. Yang, D., O. Chertov, and J. J. Oppenheim. 2001. The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity. Cell. Mol. Life Sci. 58:978.
15. Yang, D., O. Chertov, S. N. Bykovskaia, Q. Chen, M. J. Buffo, J. Shogan, M. Anderson, J. M. Schroder, J. M. Wang, O. M. Howard, and J. J. Oppenheim. 1999. β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525.
16. Nakayama, T., R. Fujisawa, H. Yamada, T. Honkawa, H. Kawasaki, K. Hieshima, D. Izawa, S. Fujiie, T. Tezuka, and O. Yoshie. 2001. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (M1P)-3 α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int. Immunol. 13:95.
17. Krijgsveld, J., S. A. Zaat, J. Meeldijk, P. A. van Veelen, G. Fang, B. Poolman, E. Brandt, J. E. Ehlert, A. J. Kuijpers, G. H. Engbers, J. Feijen, and J. Dankert. 2000. Thrombocidins, microbicidal proteins from human blood platelets, are C- terminal deletion products of CXC chemokines. J. Biol. Chem. 275:20374.
18. Cole, A. M., T. Ganz, A. M. Liese, M. D. Burdick, L. Liu, and R. M. Strieter. 2001. Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167:623.
19. Tsai, H., and L. A. Bobek. 1998. Human salivary histatins: promising anti-fungal therapeutic agents. Crit. Rev. Oral Biol. Med. 9:480.
20. Schild, L., and S. Kellenberger. 2001. Structure function relationships of ENaC and its role in sodium handling. Adv. Exp. Med. Biol. 502:305.
21. Manjunath, N., P. Shankar, J. Wan, W. Weninger, M. A. Crowley, K. Hieshima, T. A. Springer, X. Fan, H. Shen, J. Lieberman, and U. H. von Andrian. 2001. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J. Clin. Invest. 108:871.
22. H3 domains on in vivo effector function. J. Immunol. 161:3862.
23. Katou, F., H. Ohtani, T. Nakayama, K. Ono, K. Matsushima, A. Saaristo, H. Nagura, O. Yoshie, and K. Motegi. 2001. Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue. Am. J. Pathol. 158:1263.
24. Raj, P. A., M. Edgerton, and M. J. Levine. 1990. Salivary histatin 5: dependence of sequence, chain length, and helical conformation for candidacidal activity. J. Biol. Chem. 265:3898.
25. Helmerhorst, E. J., P. Breeuwer, W. van't Hof, E. Walgreen-Weterings, L. C. Oomen, E. C. Veerman, A. V. Amerongen, and T. Abee. 1999. The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. J. Biol. Chem. 274:7286.
26. Oppenheim, F. G., T. Xu, F. M. McMillian, S. M. Levitz, R. D. Diamond, G. D. Offner, and R. F. Troxler. 1988. Histatins, a novel family of histidine-rich proteins in human parotid secretion: isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J. Biol Chem. 263:7472.
27. Xu, T., S. M. Levitz, R. D. Diamond, and F. G. Oppenheim. 1991. Anticandidal activity of major human salivary histafins. Infect. Immun. 59:2549.
28. 2+ ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles: identification and characterization of a zinc-binding motif present in the functional domain. Biochemistry 38:9626.
29. Hirose, J., H. Iwamoto, I. Nagao, K. Enmyo, H. Sugao, N. Kanemitu, K. Ikeda, M. Takeda, M. Inoue, T. Ikeda. et al. 2001. Characterizafion of the metal-substituted dipeptidyl peptidase III (rat liver). Biochemistry 40:11860.
30. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454.
31. Hargreaves, D. C., P. L. Hyman, T. T. Lu, V. N. Ngo, A. Bidgol, G. Suzuki, Y.-R. Zou, D. R. Littman, and G. Cyster. 2001. A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med. 194:45.
32. Lortat-Jacob, H., A. Grosdidier, and A. Imberty. 2002. Structural diversity of heparan sulfate binding domains in chemokines. Proc. Natl. Acad. Sci. USA 99:1229.
33. Yan, H., and R. E. Hancock. 2001. Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob. Agents Chemother. 45:1558.
34. Edgerton, M., S. E. Koshlukova, T. E. Lo, B. G. Chrzan, R. M. Straubinger, and P. A. Raj. 1998. Candidacidal activity of salivary histatins: identification of a histatin 5-binding protein on Candida albicans. J. Biol. Chem. 273:20438.
35. Helmerhorst, E. J., W. van't Hof, P. Breeuwer, E. C. Veerman, T. Abee, R. F. Troxler, A. V. Amerongen, and F. G. Oppenheim. 2001. Characterization of histatin 5 with respect to amphipathicity, hydrophobicity, and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation. J. Biol. Chem. 276:5643.
36. Gotoh, O. 1999. Multiple sequence alignment: algorithms and applications. Adv. Biophys. 36:159.