Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National Institutes of Health StrokeNet

Stroke

Volumn 48, Issue 3, 2017, Pages 813-819

  Cramer, Steven C ^a,b,c   Wolf, Steven L ^d,e   Adams, Harold P ^f   Chen, Daofen ^g   Dromerick, Alexander W ^h,i   Dunning, Kari ^j   Ellerbe, Caitlyn ^k   Grande, Andrew ^l   Janis, Scott ^g   Lansberg, Maarten G ^m   Lazar, Ronald M ⁿ   Palesch, Yuko Y ^k   Richards, Lorie ^o   Roth, Elliot ^p   Savitz, Sean I ^q   Wechsler, Lawrence R ^r   Wintermark, Max ^s   Broderick, Joseph P ^j,t  

^a Anatomy and Neurobiology   (United States)

^b Physical Medicine and Rehabilitation   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VA Center of Excellence and Neurocognitive Rehabilitation   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^h GEORGETOWN UNIVERSITY   (United States)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^j UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^k MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^l UNIVERSITY OF MINNESOTA   (United States)

^m STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ Columbia University College of Physicians and Surgeons ^*  (United States)

^o UNIVERSITY OF UTAH   (United States)

^p NORTHWESTERN UNIVERSITY   (United States)

^q UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^r UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^s STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^t UNIVERSITY OF CINCINNATI   (United States)

more..

Author keywords

brain; clinical trial; rehabilitation; stem cells; stroke

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; BEHAVIOR CHANGE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL (TOPIC); CONVALESCENCE; EMERGENCY CARE; HEALTH CARE DELIVERY; HOSPITAL DISCHARGE; HUMAN; LOCOMOTION; NATIONAL HEALTH ORGANIZATION; NEUROPROTECTION; NEUROREHABILITATION; OUTCOME ASSESSMENT; PATIENT ATTITUDE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; REHABILITATION RESEARCH; REPERFUSION; SOCIAL ASPECT; TRANSLATIONAL RESEARCH; METHODOLOGY; STROKE REHABILITATION; UNITED STATES;

CLINICAL TRIALS AS TOPIC; HUMANS; NATIONAL INSTITUTES OF HEALTH (U.S.); REHABILITATION RESEARCH; RESEARCH DESIGN; STROKE REHABILITATION; UNITED STATES;

EID: 85011805762     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.116.015501     Document Type: Article

References (54)

1. Adeoye O, Hornung R, Khatri P, Kleindorfer D. Recombinant tissuetype plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke. 2011;42:1952-1955. doi: 10.1161/STROKEAHA.110.612358.
2. Adams HP Jr, Nudo RJ. Management of patients with stroke: is it time to expand treatment options? Ann Neurol. 2013;74:4-10. doi: 10.1002/ ana.23948.
3. Hermann DM, Chopp M. Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 2012;11:369-380. doi: 10.1016/ S1474-4422(12)70039-X.
4. Carmichael ST. Emergent properties of neural repair: elemental biology to therapeutic concepts. Ann Neurol. 2016;79:895-906. doi: 10.1002/ ana.24653.
5. Cramer SC. Repairing the human brain after stroke. II. Restorative therapies. Ann Neurol. 2008;63:549-560. doi: 10.1002/ana.21412.
6. Carter AR, Connor LT, Dromerick AW. Rehabilitation after stroke: current state of the science. Curr Neurol Neurosci Rep. 2010;10:158-166. doi: 10.1007/s11910-010-0091-9.
7. Wolf SL, Winstein CJ, Miller JP, Taub E, Uswatte G, Morris D, et al; EXCITE Investigators. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA. 2006;296:2095-2104. doi: 10.1001/ jama.296.17.2095.
8. Duncan PW, Sullivan KJ, Behrman AL, Azen SP, Wu SS, Nadeau SE, et al; LEAPS Investigative Team. Body-weight-supported treadmill rehabilitation after stroke. N Engl J Med. 2011;364:2026-2036. doi: 10.1056/ NEJMoa1010790.
9. Chollet F, Tardy J, Albucher JF, Thalamas C, Berard E, Lamy C, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10:123-130. doi: 10.1016/S1474-4422(10)70314-8.
10. Scheidtmann K, Fries W, Müller F, Koenig E. Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: a prospective, randomised, double-blind study. Lancet. 2001;358:787-790. doi: 10.1016/S0140-6736(01)05966-9.
11. Bayley MT, Hurdowar A, Richards CL, Korner-Bitensky N, Wood- Dauphinee S, Eng JJ, et al. Barriers to implementation of stroke rehabilitation evidence: findings from a multi-site pilot project. Disabil Rehabil. 2012;34:1633-1638. doi: 10.3109/09638288.2012.656790.
12. Winstein CJ, Wolf SL, Dromerick AW, Lane CJ, Nelsen MA, Lewthwaite R, et al; Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) Investigative Team. Effect of a Task-Oriented Rehabilitation Program on Upper Extremity Recovery Following Motor Stroke: The ICARE Randomized Clinical Trial. JAMA. 2016;315:571-581. doi: 10.1001/jama.2016.0276.
13. Lang CE, Strube MJ, Bland MD, Waddell KJ, Cherry-Allen KM, Nudo RJ, et al. Dose response of task-specific upper limb training in people at least 6 months poststroke: A phase II, single-blind, randomized, controlled trial. Ann Neurol. 2016;80:342-354. doi: 10.1002/ana.24734.
14. Broderick JP, Palesch YY, Janis LS; National Institutes of Health StrokeNet Investigators. The National Institutes of Health StrokeNet: A User's Guide. Stroke. 2016;47:301-303. doi: 10.1161/STROKEAHA. 115.011743.
15. Documents. NIH StrokeNet. Available at: www.nihstrokenet.org/documents. Accessed December 13, 2016.
16. Savitz SI, Cramer SC, Wechsler L; STEPS 3 Consortium. Stem cells as an emerging paradigm in stroke 3: enhancing the development of clinical trials. Stroke. 2014;45:634-639. doi: 10.1161/ STROKEAHA.113.003379.
17. Campbell GB, Skidmore ER, Whyte EM, Matthews JT. Overcoming practical challenges to conducting clinical research in the inpatient stroke rehabilitation setting. Top Stroke.Rehabil. 2015;22:386-395. doi: 10.1179/1074935714Z.0000000045.
18. Cramer SC, Koroshetz WJ, Finklestein SP. The case for modalityspecific outcome measures in clinical trials of stroke recoverypromoting agents. Stroke. 2007;38:1393-1395. doi: 10.1161/01. STR.0000260087.67462.80.
19. Cramer SC, Dobkin BH, Noser EA, Rodriguez RW, Enney LA. Randomized, placebo-controlled, double-blind study of ropinirole in chronic stroke. Stroke. 2009;40:3034-3038. doi: 10.1161/ STROKEAHA.109.552075.
20. Blanton S, Morris DM, Prettyman MG, McCulloch K, Redmond S, Light KE, et al. Lessons learned in participant recruitment and retention: the EXCITE trial. Phys Ther. 2006;86:1520-1533. doi: 10.2522/ ptj.20060091.
21. Clinicaltrials.gov website. Telerehabilitation in the home versus therapy inclinic for patients with stroke. Unique identifier: NCT02360488. https:// www.clinicaltrials.gov/show/NCT02360488. Accessed December 13, 2016.
22. Nowacki AS, Zhao W, Palesch YY. A surrogate-primary replacement algorithm for response-adaptive randomization in stroke clinical trials [published online ahead of print January 12, 2015]. Stat Methods Med Res. doi: 10.1177/0962280214567142. http://journals.sagepub.com/doi/10. 1177/0962280214567142. Accessed September 30, 2016.
23. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, et al. Harnessing neuroplasticity for clinical applications. Brain. 2011;134(pt 6):1591-1609. doi: 10.1093/brain/awr039.
24. Urbin MA, Bailey RR, Lang CE. Validity of body-worn sensor acceleration metrics to index upper extremity function in hemiparetic stroke. J Neurol Phys Ther. 2015;39:111-118. doi: 10.1097/NPT.0000000000000085.
25. Willems D, Salter K, Meyer M, McClure A, Teasell R, Foley N. Determining the need for in-patient rehabilitation services post-stroke: results from eight ontario hospitals. Healthc Policy. 2012;7:e105-e118.
26. Randolph AG. The unique challenges of enrolling patients into multiple clinical trials. Crit Care Med. 2009;37(suppl 1):S107-S111. doi: 10.1097/CCM.0b013e3181921c9d.
27. Dennis M, Wardlaw J, Sandercock P, Signorini D, Warlow C. Families of trials: the answers to all our questions? Cerebrovasc Dis. 1999;9:305-313. doi: 16003.
28. Myles PS, Williamson E, Oakley J, Forbes A. Ethical and scientific considerations for patient enrollment into concurrent clinical trials. Trials. 2014;15:470. doi: 10.1186/1745-6215-15-470.
29. Cumming TB, Marshall RS, Lazar RM. Stroke, cognitive deficits, and rehabilitation: still an incomplete picture. Int J Stroke. 2013;8:38-45. doi: 10.1111/j.1747-4949.2012.00972.x.
30. Nouri S, Cramer SC. Anatomy and physiology predict response to motor cortex stimulation after stroke. Neurology. 2011;77:1076-1083. doi: 10.1212/WNL.0b013e31822e1482.
31. Stinear CM, Barber PA, Petoe M, Anwar S, Byblow WD. The PREP algorithm predicts potential for upper limb recovery after stroke. Brain. 2012;135(pt 8):2527-2535. doi: 10.1093/brain/aws146.
32. Crinion JT, Leff AP. Using functional imaging to understand therapeutic effects in poststroke aphasia. Curr Opin Neurol. 2015;28:330-337. doi: 10.1097/WCO.0000000000000217.
33. Carter AR, Shulman GL, Corbetta M. Why use a connectivity-based approach to study stroke and recovery of function? Neuroimage. 2012;62:2271-2280. doi: 10.1016/j.neuroimage.2012.02.070.
34. Burke Quinlan E, Dodakian L, See J, McKenzie A, Le V, Wojnowicz M, et al. Neural function, injury, and stroke subtype predict treatment gains after stroke. Ann Neurol. 2015;77:132-145. doi: 10.1002/ana.24309.
35. Biernaskie J, Chernenko G, Corbett D. Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. J Neurosci. 2004;24:1245-1254. doi: 10.1523/JNEUROSCI.3834-03.2004.
36. Kerr AL, Cheng SY, Jones TA. Experience-dependent neural plasticity in the adult damaged brain. J Commun Disord. 2011;44:538-548. doi: 10.1016/j.jcomdis.2011.04.011.
37. Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J Speech Lang Hear Res. 2008;51:S225-S239. doi: 10.1044/1092-4388(2008/018).
38. Barbay S, Nudo RJ. The effects of amphetamine on recovery of function in animal models of cerebral injury: a critical appraisal. NeuroRehabilitation. 2009;25:5-17. doi: 10.3233/NRE-2009-0495.
39. Liebeskind DS, Albers GW, Crawford K, Derdeyn CP, George MS, Palesch YY, et al. Imaging in StrokeNet: Realizing the Potential of Big Data. Stroke. 2015;46:2000-2006. doi: 10.1161/STROKEAHA.115.009479.
40. Burke E, Cramer SC. Biomarkers and predictors of restorative therapy effects after stroke. Curr Neurol Neurosci Rep. 2013;13:329. doi: 10.1007/s11910-012-0329-9.
41. Seitz RJ, Donnan GA. Recovery Potential After Acute Stroke. Front Neurol. 2015;6:238. doi: 10.3389/fneur.2015.00238.
42. Borich MR, Brown KE, Lakhani B, Boyd LA. Applications of electroencephalography to characterize brain activity: perspectives in stroke. J Neurol Phys Ther. 2015;39:43-51. doi: 10.1097/ NPT.0000000000000072.
43. Newton JM, Ward NS, Parker GJ, Deichmann R, Alexander DC, Friston KJ, et al. Non-invasive mapping of corticofugal fibres from multiple motor areas-relevance to stroke recovery. Brain. 2006;129(pt 7):1844-1858. doi: 10.1093/brain/awl106.
44. Wang J, Marchina S, Norton AC, Wan CY, Schlaug G. Predicting speech fluency and naming abilities in aphasic patients. Front Hum Neurosci. 2013;7:831. doi: 10.3389/fnhum.2013.00831.
45. Corbetta M, Ramsey L, Callejas A, Baldassarre A, Hacker CD, Siegel JS, et al. Common behavioral clusters and subcortical anatomy in stroke. Neuron. 2015;85:927-941. doi: 10.1016/j.neuron.2015.02.027.
46. Liew SL, Santarnecchi E, Buch ER, Cohen LG. Non-invasive brain stimulation in neurorehabilitation: local and distant effects for motor recovery. Front Hum Neurosci. 2014;8:378. doi: 10.3389/fnhum.2014.00378.
47. Campbell BC, Donnan GA, Lees KR, Hacke W, Khatri P, Hill MD, et al. Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke. Lancet Neurol. 2015;14:846-854. doi: 10.1016/ S1474-4422(15)00140-4.
48. Santisteban L, Térémetz M, Bleton JP, Baron JC, Maier MA, Lindberg PG. Upper Limb Outcome Measures Used in Stroke Rehabilitation Studies: A Systematic Literature Review. PLoS One. 2016;11:e0154792. doi: 10.1371/journal.pone.0154792.
49. Bernhardt J, Borschmann K, Boyd L, Thomas Carmichael S, Corbett D, Cramer SC, et al. Moving rehabilitation research forward: Developing consensus statements for rehabilitation and recovery research. Int J Stroke. 2016;11:454-458. doi: 10.1177/1747493016643851.
50. Saver JL, Warach S, Janis S, Odenkirchen J, Becker K, Benavente O, et al; National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element Working Group. Standardizing the structure of stroke clinical and epidemiologic research data: the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) project. Stroke. 2012;43:967-973. doi: 10.1161/ STROKEAHA.111.634352.
51. Duff SV, He J, Nelsen MA, Lane CJ, Rowe VT, Wolf SL, et al. Interrater reliability of the Wolf Motor Function Test-Functional Ability Scale: why it matters. Neurorehabil Neural Repair. 2015;29:436-443. doi: 10.1177/1545968314553030.
52. Yozbatiran N, Der-Yeghiaian L, Cramer SC. A standardized approach to performing the action research arm test. Neurorehabil Neural Repair. 2008;22:78-90. doi: 10.1177/1545968307305353.
53. See J, Dodakian L, Chou C, Chan V, McKenzie A, Reinkensmeyer DJ, et al. A standardized approach to the Fugl-Meyer assessment and its implications for clinical trials. Neurorehabil Neural Repair. 2013;27:732-741. doi: 10.1177/1545968313491000.
54. Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, et al. Framework for design and evaluation of complex interventions to improve health. BMJ. 2000;321:694-696.