1H NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol

Journal of Proteome Research

Volumn 16, Issue 2, 2017, Pages 824-830

  Chen, Tongtong ^a   Sheng, Jiyang ^a   Fu, Yonghong ^a   Li, Minghui ^a   Wang, Junsong ^a   Jia, Ai Qun ^a,b  

^a NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HAINAN UNIVERSITY   (China)

Author keywords

1H NMR; metabolomics; Pseudomonas aeruginosa; quorum sensing; resveratrol

Indexed keywords

2 OXOGLUTARIC ACID; ACETAMIDE; ACETIC ACID; AMINE; AMINO ACID; ASPARTIC ACID; BETAINE; CARBOXYLIC ACID; DIMETHYLAMINE; ETHANOLAMINE; FORMIC ACID; FUMARIC ACID; GLUTAMINE; ISOBUTYRIC ACID; ISOLEUCINE; LEUCINE; METHANOL; N ACETYLGLUTAMIC ACID; OXIPURINOL; PYOCYANINE; RESVERATROL; SARCOSINE; SERINE; SUCCINIC ACID; TRIMETHYLAMINE; VALINE; ANTIINFECTIVE AGENT; PLANT EXTRACT; STILBENE DERIVATIVE; VIRULENCE FACTOR;

ANAEROBIC GROWTH; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOTOXICITY; ENERGY METABOLISM; GENE EXPRESSION; GROWTH INHIBITION; METABOLOMICS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; STORAGE; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOFILM; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; ISOLATION AND PURIFICATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE; SARSAPARILLA;

ANTI-BACTERIAL AGENTS; BIOFILMS; CITRIC ACID CYCLE; GENE EXPRESSION REGULATION, BACTERIAL; GLYCOLYSIS; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATIVE STRESS; PLANT EXTRACTS; PROTEIN BIOSYNTHESIS; PSEUDOMONAS AERUGINOSA; PYOCYANINE; QUORUM SENSING; SMILAX; STILBENES; VIRULENCE FACTORS;

EID: 85011705460     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.6b00800     Document Type: Article

References (27)

1. Schauder, S.; Bassler, B. L. The languages of bacteria Genes Dev. 2001, 15, 1468-80 10.1101/gad.899601
2. Fuqua, C.; Greenberg, E. P. Listening in on bacteria: acyl-homoserine lactone signalling Nat. Rev. Mol. Cell Biol. 2002, 3, 685-95 10.1038/nrm907
3. Whitehead, N. A.; Barnard, A. M. L.; Slater, H.; Simpson, N. J. L.; Salmond, G. P. C. Quorum-sensing in Gram-negative bacteria Fems Microbiol Rev. 2001, 25, 365-404 10.1111/j.1574-6976.2001.tb00583.x
4. Rutherford, S. T.; Bassler, B. L. Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control Cold Spring Harbor Perspect. Med. 2012, 2, 705-709 10.1101/cshperspect.a012427
5. Bjarnsholt, T.; Givskov, M. The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa Anal. Bioanal. Chem. 2007, 387, 409-14 10.1007/s00216-006-0774-x
6. Jimenez, P. N.; Koch, G.; Thompson, J. A.; Xavier, K. B.; Cool, R. H.; Quax, W. J. The multiple signaling systems regulating virulence in Pseudomonas aeruginosa Microbiol Mol. Biol. Rev. 2012, 76, 46-65 10.1128/MMBR.05007-11
7. Parsek, M. R.; Greenberg, E. P. Sociomicrobiology: the connections between quorum sensing and biofilms Trends Microbiol. 2005, 13, 27-33 10.1016/j.tim.2004.11.007
8. Smith, R. P. aeruginosa quorum-sensing systems and virulence Curr. Opin. Microbiol. 2003, 6, 56-60 10.1016/S1369-5274(03)00008-0
9. Rasmussen, T. B.; Givskov, M. Quorum-sensing inhibitors as anti-pathogenic drugs Int. J. Med. Microbiol. 2006, 296, 149-161 10.1016/j.ijmm.2006.02.005
10. Kalia, V. C. Quorum sensing inhibitors: an overview Biotechnol. Adv. 2013, 31, 224-45 10.1016/j.biotechadv.2012.10.004
11. Hentzer, M.; Wu, H.; Andersen, J. B.; Riedel, K.; Rasmussen, T. B.; Bagge, N.; Kumar, N.; Schembri, M. A.; Song, Z.; Kristoffersen, P. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors EMBO J. 2003, 22, 3803-3815 10.1093/emboj/cdg366
12. Jakobsen, T. H.; van Gennip, M.; Phipps, R. K.; Shanmugham, M. S.; Christensen, L. D.; Alhede, M.; Skindersoe, M. E.; Rasmussen, T. B.; Friedrich, K.; Uthe, F.; Jensen, P. O.; Moser, C.; Nielsen, K. F.; Eberl, L.; Larsen, T. O.; Tanner, D.; Hoiby, N.; Bjarnsholt, T.; Givskov, M. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing Antimicrob. Agents Chemother. 2012, 56, 2314-25 10.1128/AAC.05919-11
13. Yang, Y. X.; Xu, Z. H.; Zhang, Y. Q.; Tian, J.; Weng, L. X.; Wang, L. H. A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa J. Microbiol. 2012, 50, 987-93 10.1007/s12275-012-2149-7
14. Liu, Y.; Chen, T.; Li, M.-H.; Xu, H.-D.; Jia, A.-Q.; Zhang, J.-F.; Wang, J.-S. 1H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus) Chemosphere 2015, 138, 537-545 10.1016/j.chemosphere.2015.07.030
15. Chen, F.; Zhang, J.; Song, X.; Yang, J.; Li, H.; Tang, H.; Liao, Y. C. Combined metabonomic and quantitative real-time PCR analyses reveal systems metabolic changes of Fusarium graminearum induced by Tri5 gene deletion J. Proteome Res. 2011, 10, 2273-85 10.1021/pr101095t
16. Ye, Y.; Zhang, L.; Hao, F.; Zhang, J.; Wang, Y.; Tang, H. Global Metabolomic Responses of Escherichia coli to Heat Stress J. Proteome Res. 2012, 11, 2559-2566 10.1021/pr3000128
17. Frémont, L. Biological effects of resveratrol Life Sci. 2000, 66, 663-673 10.1016/S0024-3205(99)00410-5
18. Sheng, J. Y.; Chen, T. T.; Tan, X. J.; Chen, T.; Jia, A. Q. The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship Bioorg. Med. Chem. Lett. 2015, 25, 5217-20 10.1016/j.bmcl.2015.09.064
19. Li, M.; Wang, J.; Lu, Z.; Wei, D.; Yang, M.; Kong, L. NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus) Aquat. Toxicol. 2014, 146, 82-92 10.1016/j.aquatox.2013.10.024
20. Li, P.; Liao, S.; Wang, J.; Xu, D.; Zhang, Q.; Yang, M.; Kong, L. NMR metabolic profiling of lipopolysaccharide-induced mice sepsis and the treatment effects of berberine RSC Adv. 2016, 6, 47474-47485 10.1039/C6RA04717C
21. Nicas, T. I.; Iglewski, B. H. The contribution of exoproducts to virulence of Pseudomonas aeruginosa Can. J. Microbiol. 1985, 31, 387-92 10.1139/m85-074
22. Van Delden, C.; Iglewski, B. H. Cell-to-cell signaling and Pseudomonas aeruginosa infections Emerging Infect. Dis. 1998, 4, 551-560 10.3201/eid0404.980405
23. Tkachenko, A. G.; Nesterova, L. Y.; Pshenichnov, M. P. Role of Putrescine in the Regulation of the Expression of the Oxidative Stress Defense Genes of Escherichia coli Microbiology 2001, 70, 133-137 10.1023/A:1010365110538
24. Schmidley, J. W. Free radicals in central nervous system ischemia Stroke 1990, 21, 1086-90 10.1161/01.STR.21.7.1086
25. Juhas, M.; Wiehlmann, L.; Huber, B.; Jordan, D.; Lauber, J.; Salunkhe, P.; Limpert, A. S.; von Gotz, F.; Steinmetz, I.; Eberl, L.; Tummler, B. Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa Microbiology 2004, 150, 831-41 10.1099/mic.0.26906-0
26. Ringø, E.; Stenberg, E.; Strøm, A. R. Amino acid and lactate catabolism in trimethylamine oxide respiration of Alteromonas putrefaciens NCMB 1735 Appl. Environ. Microb. 1984, 47, 1084-9
27. Lee, K. M.; Yoon, M. Y.; Park, Y.; Lee, J. H.; Yoon, S. S. Anaerobiosis-induced loss of cytotoxicity is due to inactivation of quorum sensing in Pseudomonas aeruginosa Infect. Immun. 2011, 79, 2792-800 10.1128/IAI.01361-10