메뉴 건너뛰기




Volumn 12, Issue 2, 2017, Pages

Clinical impact of pharmacogenetic profiling with a clinical decision support tool in polypharmacy home health patients: A prospective pilot randomized controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHRONIC DISEASE; CLINICAL PRACTICE; CONTROLLED STUDY; FEMALE; GENE INTERACTION; GENETIC ALGORITHM; GENOTYPING TECHNIQUE; HEALTH CARE UTILIZATION; HIGH RISK POPULATION; HOME CARE; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT REFERRAL; PHARMACOGENETICS; PILOT STUDY; POLYPHARMACY; PRESCRIPTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SOFTWARE; CLINICAL DECISION SUPPORT SYSTEM; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENE EXPRESSION PROFILING; GENETICS; HOSPITALIZATION; MIDDLE AGED; OUTCOME ASSESSMENT; PHARMACOGENETIC VARIANT;

EID: 85011659668     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0170905     Document Type: Article
Times cited : (110)

References (36)
  • 2
    • 0025231961 scopus 로고
    • Opportunities and responsibilities in pharmaceutical care
    • PMID: 2316538
    • Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990; 47(3):533-43. PMID: 2316538.
    • (1990) Am J Hosp Pharm , vol.47 , Issue.3 , pp. 533-543
    • Hepler, C.D.1    Strand, L.M.2
  • 3
    • 84907016697 scopus 로고    scopus 로고
    • Emergency department visits by adults for psychiatric medication adverse events
    • PMID: 25006837
    • Hampton LM, Daubresse M, Chang HY, Alexander GC, Budnitz DS. Emergency department visits by adults for psychiatric medication adverse events. JAMA Psychiatry. 2014; 71(9):1006-14. doi:10.1001/jamapsychiatry.2014.436 PMID: 25006837.
    • (2014) JAMA Psychiatry , vol.71 , Issue.9 , pp. 1006-1014
    • Hampton, L.M.1    Daubresse, M.2    Chang, H.Y.3    Alexander, G.C.4    Budnitz, D.S.5
  • 4
    • 84875211310 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
    • PMID: 23333322
    • Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013; 138(1):103-41. doi:10.1016/j.pharmthera.2012.12.007 PMID: 23333322.
    • (2013) Pharmacol Ther , vol.138 , Issue.1 , pp. 103-141
    • Zanger, U.M.1    Schwab, M.2
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • PMID: 10521338
    • Evans WE, Relling MV. Pharmacogenomics: Translating functional genomics into rational therapeutics. Science. 1999; 286(5439):487-91. PMID: 10521338.
    • (1999) Science , vol.286 , Issue.5439 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • PMID: 15917386
    • Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med. 2005; 352(21):2211-21. doi:10.1056/NEJMra032424PMID: 15917386.
    • (2005) N Engl J Med , vol.352 , Issue.21 , pp. 2211-2221
    • Wilkinson, G.R.1
  • 8
    • 58149269468 scopus 로고    scopus 로고
    • Use of prescription and overthe- counter medications and dietary supplements among older adults in the United States
    • PMID: 19109115
    • Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, Lindau ST. Use of prescription and overthe- counter medications and dietary supplements among older adults in the United States. JAMA. 2008; 300(24):2867-78. doi:10.1001/jama.2008.892 PMID: 19109115.
    • (2008) JAMA , vol.300 , Issue.24 , pp. 2867-2878
    • Qato, D.M.1    Alexander, G.C.2    Conti, R.M.3    Johnson, M.4    Schumm, P.5    Lindau, S.T.6
  • 9
    • 37548998920 scopus 로고    scopus 로고
    • Polypharmacy in elderly patients
    • PMID: 18179993
    • Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007; 5(4):345-51. doi:10.1016/j.amjopharm.2007.12.002 PMID: 18179993.
    • (2007) Am J Geriatr Pharmacother , vol.5 , Issue.4 , pp. 345-351
    • Hajjar, E.R.1    Cafiero, A.C.2    Hanlon, J.T.3
  • 11
    • 81855169543 scopus 로고    scopus 로고
    • Emergency hospitalizations for adverse drug events in older Americans
    • PMID: 22111719
    • Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011; 365(21):2002-12. doi:10.1056/NEJMsa1103053 PMID: 22111719.
    • (2011) N Engl J Med , vol.365 , Issue.21 , pp. 2002-2012
    • Budnitz, D.S.1    Lovegrove, M.C.2    Shehab, N.3    Richards, C.L.4
  • 12
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-Analysis of prospective studies
    • PMID: 9555760
    • Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: A meta-Analysis of prospective studies. JAMA. 1998; 279(15):1200-5. PMID: 9555760.
    • (1998) JAMA , vol.279 , Issue.15 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 13
    • 84864740088 scopus 로고    scopus 로고
    • Adverse drug reactions in elderly hospitalized patients: A 12-year population-based retrospective cohort study
    • PMID: 22739715
    • Sikdar KC, Dowden J, Alaghehbandan R, MacDonald D, Peter P, Gadag V. Adverse drug reactions in elderly hospitalized patients: A 12-year population-based retrospective cohort study. Ann Pharmacother. 2012; 46(7-8):960-71. doi:10.1345/aph.1Q529 PMID: 22739715.
    • (2012) Ann Pharmacother , vol.46 , Issue.7-8 , pp. 960-971
    • Sikdar, K.C.1    Dowden, J.2    Alaghehbandan, R.3    MacDonald, D.4    Peter, P.5    Gadag, V.6
  • 14
    • 84903625870 scopus 로고    scopus 로고
    • Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings
    • PMID: 25326929
    • Fagerness J, Fonseca E, Hess GP, Scott R, Gardner KR, Koffler M, et al. Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings. Am J Manag Care. 2014; 20(5):146-56. PMID: 25326929.
    • (2014) Am J Manag Care , vol.20 , Issue.5 , pp. 146-156
    • Fagerness, J.1    Fonseca, E.2    Hess, G.P.3    Scott, R.4    Gardner, K.R.5    Koffler, M.6
  • 15
    • 84899867599 scopus 로고    scopus 로고
    • How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping
    • PMID: 24798722
    • Verbeurgt P, Mamiya T, Oesterheld J. How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping. Pharmacogenomics. 2014; 15(5):655-65. doi:10.2217/pgs.14.6PMID: 24798722.
    • (2014) Pharmacogenomics , vol.15 , Issue.5 , pp. 655-665
    • Verbeurgt, P.1    Mamiya, T.2    Oesterheld, J.3
  • 16
    • 84962812573 scopus 로고    scopus 로고
    • Cytochrome P-450 gene and drug interaction analysis in patients referred for pharmacogenetic testing
    • PMID: 26721535
    • Hocum BT, White JR Jr., Heck JW, Thirumaran RK, Moyer N, Newman R, et al. Cytochrome P-450 gene and drug interaction analysis in patients referred for pharmacogenetic testing. Am J Health Syst Pharm. 2016; 73(2):61-7. doi:10.2146/ajhp150273 PMID: 26721535.
    • (2016) Am J Health Syst Pharm , vol.73 , Issue.2 , pp. 61-67
    • Hocum, B.T.1    White, Jr.J.R.2    Heck, J.W.3    Thirumaran, R.K.4    Moyer, N.5    Newman, R.6
  • 17
    • 84959160554 scopus 로고    scopus 로고
    • The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy
    • PMID: 26478982
    • Brixner D, Biltaji E, Bress A, Unni S, Ye X, Mamiya T, et al. The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy. J Med Econ. 2016; 19(3):213-28. doi:10.3111/13696998.2015.1110160 PMID: 26478982.
    • (2016) J Med Econ , vol.19 , Issue.3 , pp. 213-228
    • Brixner, D.1    Biltaji, E.2    Bress, A.3    Unni, S.4    Ye, X.5    Mamiya, T.6
  • 21
    • 84994317658 scopus 로고    scopus 로고
    • Standardizing terms for clinical pharmacogenetic test results: Consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
    • Caudle KE, Dunnenberger HM, Freimuth RR, Peterson JF, Burlison JD, Whirl-Carrillo M, et al. Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC). Genet Med. 2016.
    • (2016) Genet Med
    • Caudle, K.E.1    Dunnenberger, H.M.2    Freimuth, R.R.3    Peterson, J.F.4    Burlison, J.D.5    Whirl-Carrillo, M.6
  • 22
    • 84962294272 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium (CPIC) Guideline for cyp2d6 and cyp2c19 genotypes and dosing of selective serotonin reuptake inhibitors
    • PMID: 25974703
    • Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015; 98(2):127-34. doi:10.1002/cpt.147PMID: 25974703.
    • (2015) Clin Pharmacol Ther , vol.98 , Issue.2 , pp. 127-134
    • Hicks, J.K.1    Bishop, J.R.2    Sangkuhl, K.3    Muller, D.J.4    Ji, Y.5    Leckband, S.G.6
  • 23
    • 84962207669 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium (CPIC) Guidelines for CYP3A5 genotype and tacrolimus dosing
    • PMID: 25801146
    • Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clin Pharmacol Ther. 2015; 98(1):19-24. doi:10.1002/cpt.113 PMID: 25801146
    • (2015) Clin Pharmacol Ther , vol.98 , Issue.1 , pp. 19-24
    • Birdwell, K.A.1    Decker, B.2    Barbarino, J.M.3    Peterson, J.F.4    Stein, C.M.5    Sadee, W.6
  • 24
    • 80052962391 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for cyp2c9 and vkorc1 genotypes and warfarin dosing
    • PMID: 21900891
    • Johnson JA, Gong L, Whirl-Carrillo M, Gage BF, Scott SA, Stein CM, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther. 2011; 90(4):625-9. doi:10.1038/clpt.2011.185 PMID: 21900891.
    • (2011) Clin Pharmacol Ther , vol.90 , Issue.4 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3    Gage, B.F.4    Scott, S.A.5    Stein, C.M.6
  • 28
    • 84954288543 scopus 로고    scopus 로고
    • Genotype and co-medication dependent CYP2D6 metabolic activity: Effects on serum concentrations of aripiprazole, haloperidol, risperidone, paliperidone and zuclopenthixol
    • PMID: 26514968
    • Lisbeth P, Vincent H, Kristof M, Bernard S, Manuel M, Hugo N. Genotype and co-medication dependent CYP2D6 metabolic activity: Effects on serum concentrations of aripiprazole, haloperidol, risperidone, paliperidone and zuclopenthixol. Eur J Clin Pharmacol. 2016; 72(2):175-84. doi:10.1007/s00228-015-1965-1 PMID: 26514968.
    • (2016) Eur J Clin Pharmacol , vol.72 , Issue.2 , pp. 175-184
    • Lisbeth, P.1    Vincent, H.2    Kristof, M.3    Bernard, S.4    Manuel, M.5    Hugo, N.6
  • 30
    • 33750106228 scopus 로고    scopus 로고
    • National surveillance of emergency department visits for outpatient adverse drug events
    • PMID: 17047216
    • Budnitz DS, Pollock DA, Weidenbach KN, Mendelsohn AB, Schroeder TJ, Annest JL. National surveillance of emergency department visits for outpatient adverse drug events. JAMA. 2006; 296(15):1858- 66. doi:10.1001/jama.296.15.1858 PMID: 17047216.
    • (2006) JAMA , vol.296 , Issue.15 , pp. 1858-1866
    • Budnitz, D.S.1    Pollock, D.A.2    Weidenbach, K.N.3    Mendelsohn, A.B.4    Schroeder, T.J.5    Annest, J.L.6
  • 31
    • 84880868718 scopus 로고    scopus 로고
    • Adjusting for multiple prognostic factors in the analysis of randomised trials
    • PMID: 23898993
    • Kahan BC, Morris TP. Adjusting for multiple prognostic factors in the analysis of randomised trials. BMC Med Res Methodol. 2013; 13:99. doi:10.1186/1471-2288-13-99 PMID: 23898993.
    • (2013) BMC Med Res Methodol , vol.13 , pp. 99
    • Kahan, B.C.1    Morris, T.P.2
  • 32
    • 84899908854 scopus 로고    scopus 로고
    • The risks and rewards of covariate adjustment in randomized trials: An assessment of 12 outcomes from 8 studies
    • PMID: 24755011
    • Kahan BC, Jairath V, Dore CJ, Morris TP. The risks and rewards of covariate adjustment in randomized trials: An assessment of 12 outcomes from 8 studies. Trials. 2014; 15:139. doi:10.1186/1745-6215-15-139 PMID: 24755011.
    • (2014) Trials , vol.15 , pp. 139
    • Kahan, B.C.1    Jairath, V.2    Dore, C.J.3    Morris, T.P.4
  • 35
    • 84929677920 scopus 로고    scopus 로고
    • Cost-effectiveness of one-Time genetic testing to minimize lifetime adverse drug reactions
    • PMID: 25987241
    • Alagoz O, Durham D, Kasirajan K. Cost-effectiveness of one-Time genetic testing to minimize lifetime adverse drug reactions. Pharmacogenomics J. 2016; 16(2):129-36. doi:10.1038/tpj.2015.39 PMID: 25987241.
    • (2016) Pharmacogenomics J , vol.16 , Issue.2 , pp. 129-136
    • Alagoz, O.1    Durham, D.2    Kasirajan, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.