A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

Journal of Alzheimer's Disease

Volumn 56, Issue 3, 2017, Pages 1037-1054

  Haddick, Patrick C G ^a,k   Larson, Jessica L ^a,j   Rathore, Nisha ^a   Bhangale, Tushar R ^a   Phung, Qui T ^a   Srinivasan, Karpagam ^a   Hansen, David V ^a   Lill, Jennie R ^a   Pericak Vance, Margaret A ^b   Haines, Jonathan ^c   Farrer, Lindsay A ^d,e   Kauwe, John S ^f   Schellenberg, Gerard D ^g   Cruchaga, Carlos ^h   Goate, Alison M ⁱ   Behrens, Timothy W ^a   Watts, Ryan J ^a   Graham, Robert R ^a   Kaminker, Joshua S ^a   Van Der Brug, Marcel ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BOSTON UNIVERSITY   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BRIGHAM YOUNG UNIVERSITY   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^j GenePeeks Inc   (United States)

^k Denali Therapeutics   (United States)

more..

Author keywords

Alzheimer's disease; astrocytes; IL 6; metalloproteases; microglia

Indexed keywords

ADAM10 ENDOPEPTIDASE; APOLIPOPROTEIN E4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; IL6R PROTEIN, HUMAN; INTERLEUKIN-6, MOUSE; RECOMBINANT PROTEIN;

AGED; ALLELE; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONFIDENCE INTERVAL; CONTROLLED STUDY; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MICROGLIA; MOUSE; NONHUMAN; ODDS RATIO; ONSET AGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; VERY ELDERLY; ANIMAL; BRAIN; CD4+ T LYMPHOCYTE; COCULTURE; COHORT ANALYSIS; FEMALE; GENETICS; HEK293 CELL LINE; MALE; META ANALYSIS; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAM10 PROTEIN; ADAM17 PROTEIN; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEIN E4; ASTROCYTES; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; COHORT STUDIES; FEMALE; HEK293 CELLS; HUMANS; INTERLEUKIN-6; MALE; MICE; MICROGLIA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS;

EID: 85011562578     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160524     Document Type: Article

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