Expression of a Distinct Set of Chemokine Receptors in Adipose Tissue‐Derived Stem Cells is Responsible for In Vitro Migration Toward Chemokines Appearing in the Major Pelvic Ganglion Following Cavernous Nerve Injury

Sexual Medicine

Volumn 1, Issue 1, 2013, Pages 3-15

  Albersen, Maarten ^a,b   Berkers, Joost ^a   Dekoninck, Philip ^b   Deprest, Jan ^b   Lue, Tom F ^c   Hedlund, Petter ^d   Lin, Ching‐Shwun ^c   Bivalacqua, Trinity J ^e   Van Poppel, Hendrik ^a   De Ridder, Dirk ^a   Van der Aa, Frank ^a  

^a SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Adipose Tissue Derived Stem Cells; Cavernous Nerve Injury; Cell Surface; Chemokine Receptors; Chemokines; Erectile Dysfunction; Intracellular; Migration

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CCR8; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CHEMOKINE RECEPTOR CXCR6; CHEMOKINE RECEPTOR CXCR7; FRACTALKINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMAL CELL DERIVED FACTOR 1;

ADIPOSE TISSUE CELL; ADIPOSE TISSUE DERIVED STEM CELL; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAVERNOUS NERVE INJURY; CELL MIGRATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR PELVIC GANGLION; MALE; MOUSE; NERVE INJURY; NONHUMAN; PELVIC GANGLION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; UPREGULATION;

EID: 85011545351     PISSN: None     EISSN: 20501161     Source Type: Journal    
DOI: 10.1002/sm2.1     Document Type: Article

References (36)

1. 1 Boorjian, S.A., Eastham, J.A., Graefen, M., Guillonneau, B., Karnes, R.J., Moul, J.W., Schaeffer, E.M., Stief, C., Zorn, K.C., A critical analysis of the long‐term impact of radical prostatectomy on cancer control and function outcomes. Eur Urol 61 (2012), 664–675.
2. 2 Albersen, M., Joniau, S., Claes, H., Van Poppel, H., Preclinical evidence for the benefits of penile rehabilitation therapy following nerve‐sparing radical prostatectomy. Adv Urol, 2008.
3. 3 Bella, A.J., Lin, G., Lin, C.-S., Hickling, D.R., Morash, C., Lue, T.F., Nerve growth factor modulation of the cavernous nerve response to injury. J Sex Med 6:suppl 3 (2009), 347–352.
4. 4 Albersen, M., Kendirci, M., Van der Aa, F., Hellstrom, W.J.G., Lue, T.F., Spees, J.L., Multipotent stromal cell therapy for cavernous nerve injury‐induced erectile dysfunction. J Sex Med 9 (2011), 385–403.
5. 5 Kendirci, M., Trost, L., Bakondi, B., Whitney, M.J., Hellstrom, W.J.G., Spees, J.L., Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol 184 (2010), 1560–1566.
6. 6 Fall, P.A., Izikki, M., Tu, L., Swieb, S., Giuliano, F., Bernabe, J., Souktani, R., Abbou, C., Adnot, S., Eddahibi, S., Yiou, R., Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol 56 (2009), 716–725.
7. 7 Bochinski, D., Lin, G.T., Nunes, L., Carrion, R., Rahman, N., Lin, C.S., Lue, T.F., The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 94 (2004), 904–909.
8. 8 Meirelles, L.d.a.S., Fontes, A.M., Covas, D.T., Caplan, A.I., Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20 (2009), 419–427.
9. 9 Albersen, M., Fandel, T.M., Lin, G., Wang, G., Banie, L., Lin, C.-S., Lue, T.F., Injections of adipose tissue‐derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7 (2010), 3331–3340.
10. 10 Yeghiazarians, Y., Zhang, Y., Prasad, M., Shih, H., Saini, S.A., Takagawa, J., Sievers, R.E., Wong, M.L., Kapasi, N.K., Mirsky, R., Koskenvuo, J., Minasi, P., Ye, J., Viswanathan, M., Angeli, F.S., Boyle, A.J., Springer, M.L., Grossman, W., Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther 17 (2009), 1250–1256.
11. 11 Zhang, H., Yang, R., Wang, Z., Lin, G., Lue, T.F., Lin, C.-S., Adipose tissue‐derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration. J Sex Med 8 (2011), 437–446.
12. 12 Fandel, T.M., Albersen, M., Lin, G., Qiu, X., Ning, H., Banie, L., Lue, T.F., Lin, C.S., Recruitment of intracavernously injected adipose‐derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol 61 (2011), 201–210.
13. 13 Albersen, M., Fandel, T.M., Zhang, H., Banie, L., Lin, G., De Ridder, D., Lin, C.S., Lue, T.F., Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. Eur Urol 59 (2011), 286–296.
14. 14 Castiglione, F., Hedlund, P., Van der Aa, F., Bivalacqua, T.J., Rigatti, P., Van Poppel, H., Montorsi, F., De Ridder, D., Albersen, M., Intratunical injection of human adipose tissue‐derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of peyronie's disease. Eur Urol 63 (2012), 551–560.
15. 15 Friedenstein, A.J., Petrakova, K.V., Kurolesova, A.I., Frolova, G.P., Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6 (1968), 230–247.
16. 16 Zhang, H., Albersen, M., Jin, X., Lin, G., Stem cells: Novel players in the treatment of erectile dysfunction. Asian J Androl 14 (2012), 145–155.
17. 17 Lin, C.-S., Xin, Z.-C., Deng, C.-H., Ning, H., Lin, G., Lue, T.F., Defining adipose tissue‐derived stem cells in tissue and in culture. Histol Histopathol 25 (2010), 807–815.
18. 18 Lee, R.H., Kim, B., Choi, I., Kim, H., Choi, H.S., Suh, K., Bae, Y.C., Jung, J.S., Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 14 (2004), 311–324.
19. 19 Casteilla, L., Planat‐Benard, V., Laharrague, P., Cousin, B., Adipose‐derived stromal cells: Their identity and uses in clinical trials, an update. World J Stem Cells 3 (2011), 25–33.
20. 20 Lamfers, M., Idema, S., van Milligen, F., Schouten, T., van der Valk, P., Vandertop, P., Dirven, C., Noske, D., Homing properties of adipose‐derived stem cells to intracerebral glioma and the effects of adenovirus infection. Cancer Lett 274 (2009), 78–87.
21. 21 Kim, U., Shin, D.-G., Park, J.-S., Kim, Y.-J., Park, S.-I., Moon, Y.-M., Jeong, K.-S., Homing of adipose‐derived stem cells to radiofrequency catheter ablated canine atrium and differentiation into cardiomyocyte‐like cells. Int J Cardiol 146 (2011), 371–378.
22. 22 Lin, G., Wang, G., Banie, L., Ning, H., Shindel, A.W., Fandel, T.M., Lue, T.F., Lin, C.S., Treatment of stress urinary inconOtinence with adipose tissue‐derived stem cells. Cytotherapy 12 (2010), 88–95.
23. 23 Bobis‐Wozowicz, S., Miekus, K., Wybieralska, E., Jarocha, D., Zawisz, A., Madeja, Z., Majka, M., Genetically modified adipose tissue‐derived mesenchymal stem cells overexpressing CXCR4 display increased motility, invasiveness, and homing to bone marrow of NOD/SCID mice. Exp Hematol 39 (2011), 686–696.e4.
24. 24 Cho, H.H., Kyoung, K.M., Seo, M.J., Kim, Y.J., Bae, Y.C., Jung, J.S., Overexpression of CXCR4 increases migration and proliferation of human adipose tissue stromal cells. Stem Cells Dev 15 (2006), 853–864.
25. 25 Hung, S.-C., Pochampally, R.R., Hsu, S.-C., Sanchez, C., Chen, S.-C., Spees, J., Prockop, D.J., Short‐term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PloS ONE, 2, 2007, e416.
26. 26 Liu, X., Duan, B., Cheng, Z., Jia, X., Mao, L., Fu, H., Che, Y., Ou, L., Liu, L., Kong, D., SDF‐1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein & Cell 2 (2011), 845–854.
27. 27 Lin, G., Yang, R., Banie, L., Wang, G., Ning, H., Li, L.-C., Lue, T.F., Lin, C.S., Effects of transplantation of adipose tissue‐derived stem cells on prostate tumor. Prostate 70 (2010), 1066–1073.
28. 28 Thangarajah, H., Vial, I.N., Chang, E., El‐Ftesi, S., Januszyk, M., Chang, E.I., Paterno, J., Neofytou, E., Longaker, M.T., Gurtner, G.C., IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells 27 (2009), 266–274.
29. 29 Baek, S.J., Kang, S.K., Ra, J.C., In vitro migration capacity of human adipose tissue‐derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Exp Mol Med 43 (2011), 596–603.
30. 30 Ahmadian Kia, N., Bahrami, A.R., Ebrahimi, M., Matin, M.M., Neshati, Z., Almohaddesin, M.R., Aghdami, N., Bidkhori, H.R., Comparative analysis of chemokine receptor's expression in mesenchymal stem cells derived from human bone marrow and adipose tissue. J Mol Neurosci 44 (2011), 178–185.
31. 31 Brooke, G., Tong, H., Levesque, J.-P., Atkinson, K., Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta. Stem Cells Dev 17 (2008), 929–940.
32. 32 Chamberlain, G., Wright, K., Rot, A., Ashton, B., Middleton, J., Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: Comparison with human. PloS ONE, 3, 2008, e2934.
33. 33 Chamberlain, G., Fox, J., Ashton, B., Middleton, J., Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25 (2007), 2739–2749.
34. 34 Ponte, A.L., Marais, E., Gallay, N., Langonné, A., Delorme, B., Hérault, O., Charbord, P., Domenech, J., The in vitro migration capacity of human bone marrow meseSnchymal stem cells: Comparison of chemokine and growth factor chemotactic activities. Stem Cells 25 (2007), 1737–1745.
35. 35 Shimizu, S., Brown, M., Sengupta, R., Penfold, M.E., Meucci, O., CXCR7 protein expression in human adult brain and differentiated neurons. PloS ONE, 6, 2011, e20680.
36. 36 Tang, Y.L., Zhu, W., Cheng, M., Chen, L., Zhang, J., Sun, T., Kishore, R., Phillips, M.I., Losordo, D.W., Qin, G., Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 104 (2009), 1209–1216.