Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains

JAMA Neurology

Volumn 74, Issue 1, 2017, Pages 91-99

  Zeppenfeld, Douglas M ^a   Simon, Matthew ^a   Haswell, J Douglas ^a   D'Abreo, Daryl ^a   Murchison, Charles ^b   Quinn, Joseph F ^b   Grafe, Marjorie R ^a   Woltjer, Randall L ^a   Kaye, Jeffrey ^b   Iliff, Jeffrey J ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AQUAPORIN 4; GLIAL FIBRILLARY ACIDIC PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAAK STAGE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE ASSESSMENT; PERIVASCULAR SPACE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENILE PLAQUE; WESTERN BLOTTING; AGING; AMYLOID PLAQUE; ANALYSIS OF VARIANCE; DIAGNOSIS; FRONTAL LOBE; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; AQUAPORIN 4; COGNITION; DIAGNOSIS; FEMALE; FRONTAL LOBE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID;

EID: 85011342617     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.4370     Document Type: Article

References (30)

1. Alzheimer's Association. 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 2015; 11(3):332-384.
2. Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nat Med. 2004;10 (suppl):S10-S17.
3. Plog BA, Moll KM, Kang H, et al. A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation. J Neurosci Methods. 2014;229:44-52.
4. Kress BT, Iliff JJ, Xia M, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol. 2014;76(6):845-861.
5. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377.
6. Iliff JJ, Lee H, Yu M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 2013;123(3):1299-1309.
7. Iliff JJ,WangM, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4 (147):147ra111.
8. Moftakhar P, Lynch MD, Pomakian JL, Vinters HV. Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. J Neuropathol Exp Neurol. 2010;69(12):1201-1209.
9. Hoshi A, Yamamoto T, Shimizu K, et al. Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease. J Neuropathol Exp Neurol. 2012;71(8):750-759.
10. Wilcock DM, Vitek MP, Colton CA. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience. 2009;159(3): 1055-1069.
11. Nelson JW, Young JM, Borkar RN, et al. Role of soluble epoxide hydrolase in age-related vascular cognitive decline. Prostaglandins Other Lipid Mediat. 2014;113-115:30-37.
12. Tierney MC, Fisher RH, Lewis AJ, et al. The NINCDS-ADRDAWork Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology. 1988;38(3):359-364.
13. R: A Language and Environment for Statistical Computing [computer program]. Vienna, Austria: R Foundation for Statistical Computing; 2013.
14. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993; 43(11):2412-2414.
15. Deramecourt V, Slade JY, Oakley AE, et al. Staging and natural history of cerebrovascular pathology in dementia. Neurology. 2012;78(14): 1043-1050.
16. Crane JM, Tajima M, Verkman AS. Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience. 2010; 168(4):892-902.
17. Mawuenyega KG, SigurdsonW, Ovod V, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science. 2010;330(6012):1774.
18. Patterson BW, Elbert DL, Mawuenyega KG, et al. Age and amyloid effects on human central nervous system amyloid-beta kinetics. Ann Neurol. 2015;78(3):439-453.
19. Tarasoff-Conway JM, Carare RO, Osorio RS, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015;11(8): 457-470.
20. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010;115(5):1077-1089.
21. Simon MJ, Iliff JJ. Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease. Biochim Biophys Acta. 2016;1862(3):442-451.
22. Shibata M, Yamada S, Kumar SR, et al. Clearance of Alzheimer's amyloid-ss (1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000;106(12): 1489-1499.
23. Xu Z, Xiao N, Chen Y, et al. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol Neurodegener. 2015;10(1):58.
24. Pérez E, Barrachina M, Rodríguez A, et al. Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease. Brain Res. 2007;1128(1):164-174.
25. Yang J, Lunde LK, Nuntagij P, et al. Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease. J Alzheimers Dis. 2011;27(4):711-722.
26. Iliff JJ, Goldman SA, Nedergaard M. Implications of the discovery of brain lymphatic pathways. Lancet Neurol. 2015;14(10):977-979.
27. Chételat G, La Joie R, Villain N, et al. Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease. Neuroimage Clin. 2013;2:356-365.
28. Institute of Medicine (US), Committee on the Public Health Dimensions of Cognitive Aging, Blazer DG, Yaffe K, Liverman CT, eds. Cognitive Aging: Progress in Understanding and Opportunities For Action.Washington, DC: The National Academies Press; 2015.
29. Sonnen JA, Santa Cruz K, Hemmy LS, et al. Ecology of the aging human brain. Arch Neurol. 2011;68(8):1049-1056.
30. Erten-Lyons D,Woltjer RL, Dodge H, et al. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology. 2009;72(4):354-360.