Human gut-on-a-chip supports polarized infection of coxsackie B1 virus in vitro

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Villenave, Remi ^a,e   Wales, Samantha Q ^b   Hamkins Indik, Tiama ^a   Papafragkou, Efstathia ^b   Weaver, James C ^a   Ferrante, Thomas C ^a   Bahinski, Anthony ^a,f   Elkins, Christopher A ^b   Kulka, Michael ^b   Ingber, Donald E ^a,c,d  

^a HARVARD UNIVERSITY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c HARVARD UNIVERSITY   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e Emulate Inc   (United States)

^f GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; CASPASE;

ARTICLE; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS B1; CYTOKINE RELEASE; CYTOPATHOGENIC EFFECT; ENTEROVIRUS; ENTEROVIRUS INFECTION; ENZYME ACTIVATION; FLUID FLOW; HUMAN; HUMAN CELL; HUMAN GUT ON A CHIP; IN VITRO STUDY; INTESTINE EPITHELIUM; INTESTINE MOTILITY; LAB ON A CHIP; MICROFLUIDICS; MOTION; NONHUMAN; PATHOGENESIS; TISSUE CULTURE; VIRION; VIRUS REPLICATION; VIRUS STRAIN; APOPTOSIS; CACO-2 CELL LINE; CELL CULTURE; ENTEROVIRUS B; INTESTINE MUCOSA; METABOLISM; PHYSIOLOGY; VIRAL PLAQUE ASSAY; VIROLOGY;

APOPTOSIS; CACO-2 CELLS; CASPASES; CELLS, CULTURED; COXSACKIEVIRUS INFECTIONS; CYTOKINES; CYTOPATHOGENIC EFFECT, VIRAL; ENTEROVIRUS B, HUMAN; HUMANS; INTESTINAL MUCOSA; LAB-ON-A-CHIP DEVICES; VIRAL PLAQUE ASSAY; VIRUS REPLICATION;

EID: 85011340362     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0169412     Document Type: Article

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