A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models

Diabetologia

Volumn 58, Issue 2, 2015, Pages 346-354

  Larsson, Pär G ^a   Lakshmikanth, Tadepally ^a   Laitinen, Olli H ^b,c   Utorova, Renata ^a   Jacobson, Stella ^a   Oikarinen, Maarit ^d   Domsgen, Erna ^a   Koivunen, Minni R L ^b   Chaux, Pascal ^e   Devard, Nicolas ^e   Lecouturier, Valerie ^e   Almond, Jeffrey ^e   Knip, Mikael ^f,g   Hyöty, Heikki ^d,h   Flodström Tullberg, Malin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Vactech Oy   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e SANOFI PASTEUR   (France)

^f UNIVERSITY OF HELSINKI   (Finland)

^g TAMPERE UNIVERSITY HOSPITAL   (Finland)

^h PIRKANMAA HOSPITAL DISTRICT   (Finland)

Author keywords

Autoimmune; Coxsackievirus; Enterovirus; Neutralising antibodies; Non obese diabetic mouse; Type 1 diabetes; Vaccine

Indexed keywords

COXSACKIEVIRUS B1 VACCINE; FORMALDEHYDE; GLUCOSE; INACTIVATED VACCINE; INSULIN ANTIBODY; NEUTRALIZING ANTIBODY; RNA VACCINE; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS B1; DISEASE COURSE; DRUG EFFICACY; DRUG SAFETY; ENTEROVIRUS B; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOGENICITY; INFECTION PREVENTION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; VACCINATION; VIRUS REPLICATION; WEIGHT CHANGE; WEIGHT GAIN; WEIGHT REDUCTION; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; ENTEROVIRUS INFECTION; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY;

ANIMALS; ANTIBODIES, VIRAL; COXSACKIEVIRUS INFECTIONS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENTEROVIRUS INFECTIONS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; VIRAL VACCINES;

EID: 84922073324     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3436-0     Document Type: Article

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