Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of pseudomonas aeruginosa pneumonia

Journal of Leukocyte Biology

Volumn 101, Issue 2, 2017, Pages 543-554

  Shindo, Yuichiro ^a,b   Fuchs, Anja G ^a   Davis, Christopher G ^a   Eitas, Tim ^c   Unsinger, Jacqueline ^a   Burnham, Carey Ann D ^a   Green, Jonathan M ^a   Morre, Michel ^d   Bochicchio, Grant V ^a   Hotchkiss, Richard S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGOYA UNIVERSITY   (Japan)

^c GLAXOSMITHKLINE   (United States)

^d Revimmune   (United States)

Author keywords

IFN ; IL 17; Immunosuppression; Innate lymphoid cell; Sepsis; TNF

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 22; RECOMBINANT INTERLEUKIN 7; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; CYTOKINE; INTERLEUKIN 7; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HOST RESISTANCE; IMMUNOTHERAPY; INFECTION PREVENTION; LUNG ALVEOLUS CELL; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS PNEUMONIA; SPLENIC T CELL; SURVIVAL; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNITY; IMMUNOLOGY; LUNG; LYMPHOCYTE; LYMPHOCYTE COUNT; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SEPSIS; SIGNAL TRANSDUCTION; SPLEEN; SURVIVAL ANALYSIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY; IMMUNOTHERAPY; INTERLEUKIN-7; LUNG; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MICE, INBRED C57BL; NF-KAPPA B; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RECOMBINANT PROTEINS; SEPSIS; SIGNAL TRANSDUCTION; SPLEEN; STAT3 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS;

EID: 85011320845     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4A1215-581R     Document Type: Article

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