A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins

Neuron

Volumn 93, Issue 4, 2017, Pages 822-839.e6

  François, Amaury ^a   Low, Sarah A ^a   Sypek, Elizabeth I ^a   Christensen, Amelia J ^b   Sotoudeh, Chaudy ^a   Beier, Kevin T ^a,c   Ramakrishnan, Charu ^b   Ritola, Kimberly D ^d   Sharif Naeini, Reza ^e   Deisseroth, Karl ^b   Delp, Scott L ^b   Malenka, Robert C ^a   Luo, Liqun ^c   Hantman, Adam W ^d   Scherrer, Grégory ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

DREADD; endogenous opioid enkephalin; GABA; in vivo spinal optogenetics; opioid receptors; pain facilitation; presynaptic inhibition; RVM; spinal cord; viral circuit tracing

Indexed keywords

4 AMINOBUTYRIC ACID; ENKEPHALIN; 4 AMINOBUTYRIC ACID RECEPTOR;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BRAIN FUNCTION; BRAIN REGION; BRAIN STEM; CELL POPULATION; CONTROLLED STUDY; FEMALE; GABAERGIC SYSTEM; IN VIVO STUDY; INTERNEURON; MALE; MOUSE; NEUROANATOMY; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY; PRESYNAPTIC INHIBITION; PRESYNAPTIC NERVE; PROTEIN FUNCTION; ROSTRAL VENTROMEDIAL MEDULLA; SENSORY NERVE CELL; SOMATOSENSORY SYSTEM; SPINAL CORD DORSAL HORN; ANIMAL; MEDULLA OBLONGATA; METABOLISM; NERVE TRACT; PHYSIOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; BRAIN STEM; ENKEPHALINS; GABAERGIC NEURONS; INTERNEURONS; MEDULLA OBLONGATA; MICE, TRANSGENIC; NEURAL PATHWAYS; PAIN; SPINAL CORD; SPINAL CORD DORSAL HORN;

EID: 85011317530     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2017.01.008     Document Type: Article

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