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Volumn 91, Issue 3, 2017, Pages 371-378

A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia

Author keywords

APOA1 APOA5 gene cluster; common variants association study; GCKR; LAMC1; meta analysis; MLXIPL; TRIB1

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN A1; APOLIPOPROTEIN A5; BINDING PROTEIN; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LAMININ GAMMA1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG; APOA1 PROTEIN, HUMAN; APOA5 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; GCKR PROTEIN, HUMAN; LAMININ; MLXIPL PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 85011304360     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/cge.12859     Document Type: Article
Times cited : (7)

References (63)
  • 1
    • 78349269124 scopus 로고    scopus 로고
    • Aging and arterial stiffness
    • Lee HY, Oh BH. Aging and arterial stiffness. Circ J 2010: 74 (11): 2257–2262.
    • (2010) Circ J , vol.74 , Issue.11 , pp. 2257-2262
    • Lee, H.Y.1    Oh, B.H.2
  • 2
    • 21544467275 scopus 로고    scopus 로고
    • Pathophysiology of coronary artery disease
    • Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005: 111 (25): 3481–3488.
    • (2005) Circulation , vol.111 , Issue.25 , pp. 3481-3488
    • Libby, P.1    Theroux, P.2
  • 3
    • 70349983266 scopus 로고    scopus 로고
    • A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
    • Hegele RA, Ban MR, Hsueh N et al. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet 2009: 18 (21): 4189–4194.
    • (2009) Hum Mol Genet , vol.18 , Issue.21 , pp. 4189-4194
    • Hegele, R.A.1    Ban, M.R.2    Hsueh, N.3
  • 5
    • 84904159029 scopus 로고    scopus 로고
    • The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes
    • Talmud PJ, Futema M, Humphries SE. The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes. Curr Opin Lipidol 2014: 25 (4): 274–281.
    • (2014) Curr Opin Lipidol , vol.25 , Issue.4 , pp. 274-281
    • Talmud, P.J.1    Futema, M.2    Humphries, S.E.3
  • 6
    • 84876673908 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor mutations generate synthetic genome-wide associations
    • Oosterveer DM, Versmissen J, Defesche JC et al. Low-density lipoprotein receptor mutations generate synthetic genome-wide associations. Eur J Hum Genet 2013: 21 (5): 563–566.
    • (2013) Eur J Hum Genet , vol.21 , Issue.5 , pp. 563-566
    • Oosterveer, D.M.1    Versmissen, J.2    Defesche, J.C.3
  • 7
    • 84905437783 scopus 로고    scopus 로고
    • Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations
    • Futema M, Plagnol V, Li K et al. Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations. J Med Genet 2014: 51 (8): 537–544.
    • (2014) J Med Genet , vol.51 , Issue.8 , pp. 537-544
    • Futema, M.1    Plagnol, V.2    Li, K.3
  • 8
    • 77955070766 scopus 로고    scopus 로고
    • Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    • Johansen CT, Wang J, Lanktree MB et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 2010: 42 (8): 684–687.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 684-687
    • Johansen, C.T.1    Wang, J.2    Lanktree, M.B.3
  • 9
    • 84887058576 scopus 로고    scopus 로고
    • Common variants associated with plasma triglycerides and risk for coronary artery disease
    • Do R, Willer CJ, Schmidt EM et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013: 45 (11): 1345–1352.
    • (2013) Nat Genet , vol.45 , Issue.11 , pp. 1345-1352
    • Do, R.1    Willer, C.J.2    Schmidt, E.M.3
  • 10
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Willer CJ, Schmidt EM, Sengupta S et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013: 45 (11): 1274–1283.
    • (2013) Nat Genet , vol.45 , Issue.11 , pp. 1274-1283
    • Willer, C.J.1    Schmidt, E.M.2    Sengupta, S.3
  • 11
    • 79960644031 scopus 로고    scopus 로고
    • Genetic bases of hypertriglyceridemic phenotypes
    • Johansen CT, Hegele RA. Genetic bases of hypertriglyceridemic phenotypes. Curr Opin Lipidol 2011: 22 (4): 247–253.
    • (2011) Curr Opin Lipidol , vol.22 , Issue.4 , pp. 247-253
    • Johansen, C.T.1    Hegele, R.A.2
  • 12
    • 78149245489 scopus 로고    scopus 로고
    • Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    • Waterworth DM, Ricketts SL, Song K et al. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010: 30 (11): 2264–2276.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.11 , pp. 2264-2276
    • Waterworth, D.M.1    Ricketts, S.L.2    Song, K.3
  • 13
    • 84925844427 scopus 로고    scopus 로고
    • Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia
    • De Castro-Oros I, Cenarro A, Tejedor MT et al. Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia. Circ Cardiovasc Genet 2014: 7 (6): 814–821.
    • (2014) Circ Cardiovasc Genet , vol.7 , Issue.6 , pp. 814-821
    • De Castro-Oros, I.1    Cenarro, A.2    Tejedor, M.T.3
  • 14
    • 84863986988 scopus 로고    scopus 로고
    • Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia
    • Surendran RP, Visser ME, Heemelaar S et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med 2012: 272 (2): 185–196.
    • (2012) J Intern Med , vol.272 , Issue.2 , pp. 185-196
    • Surendran, R.P.1    Visser, M.E.2    Heemelaar, S.3
  • 15
    • 70449116131 scopus 로고    scopus 로고
    • Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemia
    • Cefalu AB, Noto D, Arpi ML et al. Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemia. J Clin Endocrinol Metab 2009: 94 (11): 4584–4590.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.11 , pp. 4584-4590
    • Cefalu, A.B.1    Noto, D.2    Arpi, M.L.3
  • 16
    • 36549038120 scopus 로고    scopus 로고
    • Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    • Peterfy M, Ben-Zeev O, Mao HZ et al. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet 2007: 39 (12): 1483–1487.
    • (2007) Nat Genet , vol.39 , Issue.12 , pp. 1483-1487
    • Peterfy, M.1    Ben-Zeev, O.2    Mao, H.Z.3
  • 17
    • 84925873493 scopus 로고    scopus 로고
    • Whole-exome sequencing reveals GPIHBP1 mutations in infantile colitis with severe hypertriglyceridemia
    • Gonzaga-Jauregui C, Mir S, Penney S et al. Whole-exome sequencing reveals GPIHBP1 mutations in infantile colitis with severe hypertriglyceridemia. J Pediatr Gastroenterol Nutr 2014: 59 (1): 17–21.
    • (2014) J Pediatr Gastroenterol Nutr , vol.59 , Issue.1 , pp. 17-21
    • Gonzaga-Jauregui, C.1    Mir, S.2    Penney, S.3
  • 18
    • 84868708551 scopus 로고    scopus 로고
    • APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
    • Dussaillant C, Serrano V, Maiz A et al. APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family. BMC Med Genet 2012: 13: 106.
    • (2012) BMC Med Genet , vol.13 , pp. 106
    • Dussaillant, C.1    Serrano, V.2    Maiz, A.3
  • 19
    • 84874030482 scopus 로고    scopus 로고
    • Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia
    • Mendoza-Barbera E, Julve J, Nilsson SK et al. Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. J Lipid Res 2013: 54 (3): 649–661.
    • (2013) J Lipid Res , vol.54 , Issue.3 , pp. 649-661
    • Mendoza-Barbera, E.1    Julve, J.2    Nilsson, S.K.3
  • 20
    • 80053652823 scopus 로고    scopus 로고
    • Two novel rare variants of APOA5 gene found in subjects with severe hypertriglyceridemia
    • Pisciotta L, Fresa R, Bellocchio A et al. Two novel rare variants of APOA5 gene found in subjects with severe hypertriglyceridemia. Clin Chim Acta 2011: 412 (23–24): 2194–2198.
    • (2011) Clin Chim Acta , vol.412 , Issue.23-24 , pp. 2194-2198
    • Pisciotta, L.1    Fresa, R.2    Bellocchio, A.3
  • 21
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Expert Panel on Detection E and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001: 285 (19): 2486–97.
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 22
    • 0346882598 scopus 로고    scopus 로고
    • Testing the genetic relation between two individuals using a panel of frequency-unknown single nucleotide polymorphisms
    • Lee WC. Testing the genetic relation between two individuals using a panel of frequency-unknown single nucleotide polymorphisms. Ann Hum Genet 2003: 67 (Pt 6): 618–619.
    • (2003) Ann Hum Genet , vol.67 , pp. 618-619
    • Lee, W.C.1
  • 23
    • 77955894071 scopus 로고    scopus 로고
    • METAL: fast and efficient meta-analysis of genomewide association scans
    • Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010: 26 (17): 2190–2191.
    • (2010) Bioinformatics , vol.26 , Issue.17 , pp. 2190-2191
    • Willer, C.J.1    Li, Y.2    Abecasis, G.R.3
  • 24
    • 78650856517 scopus 로고    scopus 로고
    • GCTA: a tool for genome-wide complex trait analysis
    • Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 2011: 88 (1): 76–82.
    • (2011) Am J Hum Genet , vol.88 , Issue.1 , pp. 76-82
    • Yang, J.1    Lee, S.H.2    Goddard, M.E.3    Visscher, P.M.4
  • 26
    • 84926519781 scopus 로고    scopus 로고
    • Further improvements to linear mixed models for genome-wide association studies
    • Widmer C, Lippert C, Weissbrod O et al. Further improvements to linear mixed models for genome-wide association studies. Sci Rep 2014: 4: 6874.
    • (2014) Sci Rep , vol.4 , pp. 6874
    • Widmer, C.1    Lippert, C.2    Weissbrod, O.3
  • 27
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Consortium WTCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007: 447 (7145): 661–678.
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 28
    • 84896048700 scopus 로고    scopus 로고
    • Gender-specific associations of the APOA1 -75G>A polymorphism with several metabolic syndrome components in Turkish adults
    • Coban N, Onat A, Guclu-Geyik F, Komurcu-Bayrak E, Can G, Erginel-Unaltuna N. Gender-specific associations of the APOA1 -75G>A polymorphism with several metabolic syndrome components in Turkish adults. Clin Chim Acta 2014: 431: 244–249.
    • (2014) Clin Chim Acta , vol.431 , pp. 244-249
    • Coban, N.1    Onat, A.2    Guclu-Geyik, F.3    Komurcu-Bayrak, E.4    Can, G.5    Erginel-Unaltuna, N.6
  • 29
    • 84923601846 scopus 로고    scopus 로고
    • Dietary patterns interact with APOA1/APOC3 polymorphisms to alter the risk of the metabolic syndrome: the Tehran Lipid and Glucose Study
    • Hosseini-Esfahani F, Mirmiran P, Daneshpour MS et al. Dietary patterns interact with APOA1/APOC3 polymorphisms to alter the risk of the metabolic syndrome: the Tehran Lipid and Glucose Study. Br J Nutr 2015: 113 (4): 644–653.
    • (2015) Br J Nutr , vol.113 , Issue.4 , pp. 644-653
    • Hosseini-Esfahani, F.1    Mirmiran, P.2    Daneshpour, M.S.3
  • 30
    • 84880175725 scopus 로고    scopus 로고
    • Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster
    • Hsu MC, Chang CS, Lee KT et al. Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster. Nutr Diabetes 2013: 3: e61.
    • (2013) Nutr Diabetes , vol.3
    • Hsu, M.C.1    Chang, C.S.2    Lee, K.T.3
  • 31
    • 84896037033 scopus 로고    scopus 로고
    • Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population
    • Iqbal R, Jahan N, Sun Y, Xue H. Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population. Mol Biol Rep 2014: 41 (3): 1545–1552.
    • (2014) Mol Biol Rep , vol.41 , Issue.3 , pp. 1545-1552
    • Iqbal, R.1    Jahan, N.2    Sun, Y.3    Xue, H.4
  • 32
    • 0025006134 scopus 로고
    • A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy
    • Nichols WC, Gregg RE, Brewer HB Jr, Benson MD. A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy. Genomics 1990: 8 (2): 318–323.
    • (1990) Genomics , vol.8 , Issue.2 , pp. 318-323
    • Nichols, W.C.1    Gregg, R.E.2    Brewer, H.B.3    Benson, M.D.4
  • 33
    • 0026712979 scopus 로고
    • Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis
    • Soutar AK, Hawkins PN, Vigushin DM et al. Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. Proc Natl Acad Sci USA 1992: 89 (16): 7389–7393.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.16 , pp. 7389-7393
    • Soutar, A.K.1    Hawkins, P.N.2    Vigushin, D.M.3
  • 34
    • 0028267150 scopus 로고
    • Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26
    • Vigushin DM, Gough J, Allan D et al. Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26. Q J Med 1994: 87 (3): 149–154.
    • (1994) Q J Med , vol.87 , Issue.3 , pp. 149-154
    • Vigushin, D.M.1    Gough, J.2    Allan, D.3
  • 35
    • 0023685449 scopus 로고
    • Variant apolipoprotein AI as a major constituent of a human hereditary amyloid
    • Nichols WC, Dwulet FE, Liepnieks J, Benson MD. Variant apolipoprotein AI as a major constituent of a human hereditary amyloid. Biochem Biophys Res Commun 1988: 156 (2): 762–768.
    • (1988) Biochem Biophys Res Commun , vol.156 , Issue.2 , pp. 762-768
    • Nichols, W.C.1    Dwulet, F.E.2    Liepnieks, J.3    Benson, M.D.4
  • 36
    • 84891789251 scopus 로고    scopus 로고
    • An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site
    • Caussy C, Charriere S, Marcais C et al. An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. Am J Hum Genet 2014: 94 (1): 129–134.
    • (2014) Am J Hum Genet , vol.94 , Issue.1 , pp. 129-134
    • Caussy, C.1    Charriere, S.2    Marcais, C.3
  • 37
    • 84898915690 scopus 로고    scopus 로고
    • A novel lipoprotein lipase gene missense mutation in Chinese patients with severe hypertriglyceridemia and pancreatitis
    • Chen TZ, Xie SL, Jin R, Huang ZM. A novel lipoprotein lipase gene missense mutation in Chinese patients with severe hypertriglyceridemia and pancreatitis. Lipids Health Dis 2014: 13: 52.
    • (2014) Lipids Health Dis , vol.13 , pp. 52
    • Chen, T.Z.1    Xie, S.L.2    Jin, R.3    Huang, Z.M.4
  • 38
    • 84904565986 scopus 로고    scopus 로고
    • A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency
    • Cui G, Li Z, Li R et al. A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency. J Am Coll Cardiol 2014: 64 (3): 267–277.
    • (2014) J Am Coll Cardiol , vol.64 , Issue.3 , pp. 267-277
    • Cui, G.1    Li, Z.2    Li, R.3
  • 39
    • 84969754518 scopus 로고    scopus 로고
    • APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children
    • Suarez-Sanchez F, Klunder-Klunder M, Valladares-Salgado A et al. APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children. Pediat Obes 2016. doi: 10.1111/ijpo.12147.
    • (2016) Pediat Obes
    • Suarez-Sanchez, F.1    Klunder-Klunder, M.2    Valladares-Salgado, A.3
  • 40
    • 84903555267 scopus 로고    scopus 로고
    • Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease
    • van de Woestijne AP, van der Graaf Y, de Bakker PI, Asselbergs FW, Spiering W, Visseren FL. Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease. PLoS One 2014: 9 (6): e101082.
    • (2014) PLoS One , vol.9 , Issue.6
    • van de Woestijne, A.P.1    van der Graaf, Y.2    de Bakker, P.I.3    Asselbergs, F.W.4    Spiering, W.5    Visseren, F.L.6
  • 41
    • 77955398001 scopus 로고    scopus 로고
    • Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study
    • Bi M, Kao WH, Boerwinkle E et al. Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. PLoS One 2010: 5 (7): e11690.
    • (2010) PLoS One , vol.5 , Issue.7
    • Bi, M.1    Kao, W.H.2    Boerwinkle, E.3
  • 42
    • 84877734582 scopus 로고    scopus 로고
    • Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis
    • Li H, Xu R, Peng X, Wang Y, Wang T. Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis. Mol Biol Rep 2013: 40 (6): 3935–3942.
    • (2013) Mol Biol Rep , vol.40 , Issue.6 , pp. 3935-3942
    • Li, H.1    Xu, R.2    Peng, X.3    Wang, Y.4    Wang, T.5
  • 43
    • 84896297091 scopus 로고    scopus 로고
    • Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women
    • Murata-Mori F, Hayashida N, Ando T et al. Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women. Clin Chem Lab Med 2014: 52 (2): 289–295.
    • (2014) Clin Chem Lab Med , vol.52 , Issue.2 , pp. 289-295
    • Murata-Mori, F.1    Hayashida, N.2    Ando, T.3
  • 44
    • 77957310400 scopus 로고    scopus 로고
    • The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
    • Onuma H, Tabara Y, Kawamoto R et al. The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. J Hum Genet 2010: 55 (9): 600–604.
    • (2010) J Hum Genet , vol.55 , Issue.9 , pp. 600-604
    • Onuma, H.1    Tabara, Y.2    Kawamoto, R.3
  • 45
    • 64149119171 scopus 로고    scopus 로고
    • Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population
    • Qi Q, Wu Y, Li H et al. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia 2009: 52 (5): 834–843.
    • (2009) Diabetologia , vol.52 , Issue.5 , pp. 834-843
    • Qi, Q.1    Wu, Y.2    Li, H.3
  • 46
    • 36649018740 scopus 로고    scopus 로고
    • The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
    • Sparso T, Andersen G, Nielsen T et al. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia 2008: 51 (1): 70–75.
    • (2008) Diabetologia , vol.51 , Issue.1 , pp. 70-75
    • Sparso, T.1    Andersen, G.2    Nielsen, T.3
  • 47
    • 78751544519 scopus 로고    scopus 로고
    • Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
    • Liu Y, Zhou D, Zhang Z et al. Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. J Lipid Res 2011: 52 (2): 354–360.
    • (2011) J Lipid Res , vol.52 , Issue.2 , pp. 354-360
    • Liu, Y.1    Zhou, D.2    Zhang, Z.3
  • 48
    • 77954637747 scopus 로고    scopus 로고
    • Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke
    • Polgar N, Jaromi L, Csongei V et al. Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke. Eur J Neurol 2010: 17 (8): 1033–1039.
    • (2010) Eur J Neurol , vol.17 , Issue.8 , pp. 1033-1039
    • Polgar, N.1    Jaromi, L.2    Csongei, V.3
  • 49
    • 50849100090 scopus 로고    scopus 로고
    • Polygenic determinants of severe hypertriglyceridemia
    • Wang J, Ban MR, Zou GY et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet 2008: 17 (18): 2894–2899.
    • (2008) Hum Mol Genet , vol.17 , Issue.18 , pp. 2894-2899
    • Wang, J.1    Ban, M.R.2    Zou, G.Y.3
  • 50
    • 84886385856 scopus 로고    scopus 로고
    • Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations
    • Zeng XN, Yin RX, Huang P et al. Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations. Lipids Health Dis 2013: 12: 156.
    • (2013) Lipids Health Dis , vol.12 , pp. 156
    • Zeng, X.N.1    Yin, R.X.2    Huang, P.3
  • 51
    • 84921878392 scopus 로고    scopus 로고
    • C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study
    • Ghasemi A, Aghajani H, Fallah S, Assadi M, Seifi M. C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study. Anadolu Kardiyol Derg 2015: 15 (1): 8–12.
    • (2015) Anadolu Kardiyol Derg , vol.15 , Issue.1 , pp. 8-12
    • Ghasemi, A.1    Aghajani, H.2    Fallah, S.3    Assadi, M.4    Seifi, M.5
  • 52
    • 78751519853 scopus 로고    scopus 로고
    • Genetic determinants of plasma triglycerides
    • Johansen CT, Kathiresan S, Hegele RA. Genetic determinants of plasma triglycerides. J Lipid Res 2011: 52 (2): 189–206.
    • (2011) J Lipid Res , vol.52 , Issue.2 , pp. 189-206
    • Johansen, C.T.1    Kathiresan, S.2    Hegele, R.A.3
  • 53
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S, Melander O, Guiducci C et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008: 40 (2): 189–197.
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3
  • 54
    • 84916206303 scopus 로고    scopus 로고
    • Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population
    • Radovica I, Fridmanis D, Silamikelis I, Nikitina-Zake L, Klovins J. Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population. Meta Gene 2014: 2: 565–578.
    • (2014) Meta Gene , vol.2 , pp. 565-578
    • Radovica, I.1    Fridmanis, D.2    Silamikelis, I.3    Nikitina-Zake, L.4    Klovins, J.5
  • 55
    • 84856451445 scopus 로고    scopus 로고
    • Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population
    • Raslova K, Dobiasova M, Hubacek JA et al. Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population. Physiol Res 2011: 60 (5): 785–795.
    • (2011) Physiol Res , vol.60 , Issue.5 , pp. 785-795
    • Raslova, K.1    Dobiasova, M.2    Hubacek, J.A.3
  • 56
    • 84878849984 scopus 로고    scopus 로고
    • Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
    • Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E et al. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. J Med Genet 2013: 50 (5): 298–308.
    • (2013) J Med Genet , vol.50 , Issue.5 , pp. 298-308
    • Weissglas-Volkov, D.1    Aguilar-Salinas, C.A.2    Nikkola, E.3
  • 57
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • Willer CJ, Sanna S, Jackson AU et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008: 40 (2): 161–169.
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3
  • 58
    • 84893948691 scopus 로고    scopus 로고
    • High plasma fatty acid concentrations were present in non-diabetic patients with coronary heart disease
    • Yang N, Guo S, Zheng F, Gan X, Ning L, Dong S. High plasma fatty acid concentrations were present in non-diabetic patients with coronary heart disease. Clin Lab 2014: 60 (1): 125–131.
    • (2014) Clin Lab , vol.60 , Issue.1 , pp. 125-131
    • Yang, N.1    Guo, S.2    Zheng, F.3    Gan, X.4    Ning, L.5    Dong, S.6
  • 59
    • 84939462659 scopus 로고    scopus 로고
    • Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease
    • Douvris A, Soubeyrand S, Naing T et al. Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease. J Am Heart Assoc 2014: 3 (3): e000884.
    • (2014) J Am Heart Assoc , vol.3 , Issue.3
    • Douvris, A.1    Soubeyrand, S.2    Naing, T.3
  • 60
    • 84903791318 scopus 로고    scopus 로고
    • Association of common genetic variants with lipid traits in the Indian population
    • Walia GK, Gupta V, Aggarwal A et al. Association of common genetic variants with lipid traits in the Indian population. PLoS One 2014: 9 (7): e101688.
    • (2014) PLoS One , vol.9 , Issue.7
    • Walia, G.K.1    Gupta, V.2    Aggarwal, A.3
  • 61
    • 84891364567 scopus 로고    scopus 로고
    • Lipoprotein lipase gene sequencing and plasma lipid profile
    • Pirim D, Wang X, Radwan ZH et al. Lipoprotein lipase gene sequencing and plasma lipid profile. J Lipid Res 2014: 55 (1): 85–93.
    • (2014) J Lipid Res , vol.55 , Issue.1 , pp. 85-93
    • Pirim, D.1    Wang, X.2    Radwan, Z.H.3
  • 62
    • 84939000675 scopus 로고    scopus 로고
    • Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population
    • Wang L, Jing J, Fu Q et al. Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population. Lipids Health Dis 2015: 14: 46.
    • (2015) Lipids Health Dis , vol.14 , pp. 46
    • Wang, L.1    Jing, J.2    Fu, Q.3
  • 63
    • 84925844427 scopus 로고    scopus 로고
    • Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia
    • De Castro-Oros I, Cenarro A, Tejedor MT et al. Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia. Circ Cardiovasc Genet 2014: 7 (6): 814–821.
    • (2014) Circ Cardiovasc Genet , vol.7 , Issue.6 , pp. 814-821
    • De Castro-Oros, I.1    Cenarro, A.2    Tejedor, M.T.3


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