Enhanced-autophagy by exenatide mitigates doxorubicin-induced cardiotoxicity

International Journal of Cardiology

Volumn 232, Issue , 2017, Pages 40-47

  Lee, Kyung Hye ^a   Cho, Haneul ^a   Lee, Sora ^a   Woo, Jong Shin ^a   Cho, Byung Hyun ^a   Kang, Jung Hee ^a   Jeong, Yun Mi ^a   Cheng, Xian Wu ^a   Kim, Weon ^a  

^a Kyung Hee University College of Medicine   (South Korea)

Author keywords

Cardiotoxicity; Doxorubicin; Glucagon like peptide 1 analogue; Prevention

Indexed keywords

CASPASE 3; DOXORUBICIN; EXENDIN 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CELL LINE; CELL SURVIVAL; DIAGNOSTIC IMAGING; DISEASE MODEL; ECHOCARDIOGRAPHY; HEART VENTRICLE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUNEL ASSAY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CARDIOTOXICITY; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOXORUBICIN; ECHOCARDIOGRAPHY; HEART VENTRICLES; IN SITU NICK-END LABELING; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VENTRICULAR FUNCTION, LEFT;

EID: 85011086280     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2017.01.123     Document Type: Article

References (33)

1. [1] Angsutararux, P., Luanpitpong, S., Issaragrisil, S., Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress. Oxidative Med. Cell. Longev., 2015, 2015, 795602.
2. [2] Sawyer, D.B., Peng, X., Chen, B., Pentassuglia, L., Lim, C.C., Mechanisms of Anthracycline Cardiac Injury: Can we identify strategies for cardio-protection?. Prog. Cardiovasc. Dis. 53 (2010), 105–113.
3. [3] Spallarossa, P., Garibaldi, S., Altieri, P., Fabbi, P., Manca, V., Nasti, S., Rossettin, P., Ghigliotti, G., Ballestrero, A., Patrone, F., Barsotti, A., Brunelli, C., Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro. J. Mol. Cell. Cardiol. 37 (2004), 837–846.
4. [4] Li, B., Kim, D.S., Yadav, R.K., Kim, H.R., Chae, H.J., Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int. J. Mol. Med. 36 (2015), 53–64.
5. [5] Yan, W., Xuan, C., Xuan, L., Xu, R., Wang, J., BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. Int. J. Clin. Exp. Pathol. 8 (2015), 1719–1724.
6. [6] Deus, C.M., Zehowski, C., Nordgren, K., Wallace, K.B., Skildum, A., Oliveira, P.J., Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts. Toxicology 334 (2015), 1–11.
7. [7] Zhang, Y., Chen, Y., Zhang, M., Tang, Y., Xie, Y., Huang, X., Li, Y., Doxorubicin induces sarcoplasmic reticulum calcium regulation dysfunction via the decrease of SERCA2 and phospholamban expressions in rats. Cell Biochem. Biophys. 70 (2014), 1791–1798.
8. [8] Olson, R.D., Gambliel, H.A., Vestal, R.E., Shadle, S.E., Charlier, H.A. Jr., Cusack, B.J., Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine. Cardiovasc. Toxicol. 5 (2005), 269–283.
9. [9] Yang, Y., Zhang, H., Li, X., Yang, T., Jiang, Q., Effects of PPARα/PGC-1α on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice. Int. J. Clin. Exp. Med. 7 (2014), 2435–2442.
10. [10] Glick, D., Barth, S., Macleod, K.F., Autophagy: cellular and molecular mechanisms. J. Pathol. 221 (2010), 3–12.
11. [11] Mariño, G., Niso-Santano, M., Baehrecke, E.H., Kroemer, G., Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 15 (2014), 81–94.
12. [12] Holst, J.J., The Physiology of glucagon-like peptide 1. Physiol. Rev. 87 (2007), 1409–1439.
13. [13] Timmers, L., Henriques, J.P., de Kleijn, D.P., Devries, J.H., Kemperman, H., Steendijk, P., Verlaan, C.W., Kerver, M., Piek, J.J., Doevendans, P.A., Pasterkamp, G., Hoefer, I.E., Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J. Am. Coll. Cardiol. 53 (2009), 501–510.
14. [14] Chang, G., Zhang, D., Liu, J., Zhang, P., Ye, L., Lu, K., Duan, Q., Zheng, A., Qin, S., Exenatide protects against hypoxia/reoxygenation-induced apoptosis by improving mitochondrial function in H9c2 cells. Exp. Biol. Med. (Maywood) 239 (2014), 414–422.
15. [15] Chang, G., Zhang, D., Yu, H., Zhang, P., Wang, Y., Zheng, A., Qin, S., Cardioprotective effects of exenatide against oxidative stress-induced injury. Int. J. Mol. Med. 32 (2013), 1011–1020.
16. [16] Chan, L.L., Shen, D., Wilkinson, A.R., Patton, W., Lai, N., Chan, E., Kuksin, D., Lin, B., Qiu, J., A novel image-based cytometry method for autophagy detection in living cells. Autophagy 8 (2012), 1371–1382.
17. [17] Zhang, Y., Xu, F., Liang, H., Cai, M., Wen, X., Li, X., Weng, J., Exenatide inhibits the growth of endometrial cancer ishikawa xenografts in nude mice. Oncol. Rep. 35 (2016), 1340–1348.
18. [18] Tawfik, M.K., Mohamed, M.I., Exenatide suppresses 1,2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor antiogensis and cell proliferation. Biomed. Pharmacother. 82 (2016), 106–116.
19. [19] Fujita, S., Ushio, S., Ozawa, N., Mesuguchi, K., Kawashiri, T., Oishi, R., Egashira, N., Exenatide facilitates recovery from oxaliplatin-induced peripheral neuropathy in rats. PLoS One, 10, 2015, e0141921.
20. [20] Lingumsky, H., Wolf, I., S Israeli, M. Haimsohn, S. Ferber, A. Karasik, B. Kaufman, T. Rubinek, The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells. Breast Cancer Res. Treat. 132 (2012), 449–461.
21. [21] Leblanc, B., Mompon, P.R., Esperandieu, O., Geffray, B., Guillermo, C., Nucleolar organizer lesions induced by doxorubicin. Toxicol. Pathol. 19 (1991), 176–183.
22. [22] Sardão, V.A., Oliveira, J.P.J., Holy, J., Oliveira, C.R., Wallace, K.B., Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol. Toxicol. 25 (2009), 227–243.
23. [23] Sheikh, A., Direct cardiovascular effects of glucagon like peptide-1. Diabetol. Metab. Syndr., 5, 2013, 47.
24. [24] Fan, R., Li, X., Gu, X., Chan, J.C., Xu, G., Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis. Diabetes Obes. Metab. 12 (2010), 815–824.
25. [25] Yusta, B., Estall, J., Drucker, D.J., Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 277 (2002), 24896–24906.
26. [26] Cao, Y.Y., Chen, Z.W., Gao, Y.H., Wang, X.X., Ma, J.Y., Chang, S.F., Qian, J.Y., Ge, J.B., Exenatide Reduces Tumor Necrosis Factor-α-induced Apoptosis in Cardiomyocytes by Alleviating Mitochondrial Dysfunction. Chin. Med. J. 128 (2015), 3211–3218.
27. [27] Liu, Y., Levine, B., Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ. 22 (2015), 367–376.
28. [28] Jia, Z., Liu, Y., Su, H., Li, M., Zhang, M., Zhu, Y., Li, T., Fang, Y., Liang, S., Safflower extract inhibiting apoptosis by inducing autophagy in myocardium derived H9c2 cell. Int. J. Clin. Exp. Med. 8 (2015), 20254–20262.
29. [29] Lu, L., Wu, W., Yan, J., Li, X., Yu, H., Yu, X., Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. Int. J. Cardiol. 134 (2009), 82–90.
30. [30] Mao, K., Klionsky, D.J., AMPK activates autophagy by phosphorylating ULK1. Circ. Res. 108 (2011), 787–788.
31. [31] Kim, J., Kundu, M., Viollet, B., Guan, K., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 (2011), 132–141.
32. [32] He, C., Zhu, H., Li, H., Zou, M.H., Xie, Z., Dissociation of bcl-2-beclin1complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes 62 (2013), 1270–1281.
33. [33] Kawaguchi, T., Takemura, G., Kanimori, H., Takeyama, T., Watanabe, T., Morishita, K., Ogino, A., Tsujimoto, A., Goto, K., Maruyama, R., Kawasaki, M., Mikami, A., Fujiwara, T., Fujiwara, H., Minatoguchi, S., Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes. Cardiovasc. Res. 96 (2012), 456–465.