Cardioprotective effects of exenatide against oxidative stress-induced injury

International Journal of Molecular Medicine

Volumn 32, Issue 5, 2013, Pages 1011-1020

  Chang, Guanglei ^a   Zhang, Dongying ^a   Yu, Hui ^a   Zhang, Peng ^a   Wang, Ying ^a   Zheng, Aihua ^a   Qin, Shu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac function; Cardiomyocyte apoptosis; Exenatide; Glucagon like peptide 1 analogue; Ischemia reperfusion; Oxidative stress induced injury

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CATALASE; CREATINE KINASE MB; EXENDIN 4; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN BAD; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; COLORIMETRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEMODYNAMICS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; VENOMS;

EID: 84885056255     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1475     Document Type: Article

References (32)

1. Acar E, Ural D, Bildirici U., Sahin T and Yilmaz I: Diabetic cardiomyopathy. Anadolu Kardiyol Derg 11: 732-737, 2011.
2. Zweier JL and Talukder MA: The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 70: 181-190, 2006.
3. Zhao ZQ: Oxidative stress-elicited myocardial apoptosis during reperfusion. Curr Opin Pharmacol 4: 159-165, 2004.
4. Gottlieb RA: Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther 16: 233-238, 2011.
5. Kajstura J, Cheng W, Reiss K., Clark WA, Sonnenblick EH, Krajewski S, Reed J.C., Olivetti G and Anversa P: Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107, 1996.
6. Palojoki E, Saraste A, Eriksson A., Pulkki K, Kallajoki M, Voipio-Pulkki LM and Tikkanen I: Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 280: H2726-H2731, 2001.
7. Garber A J: Novel GLP-1 receptor agonists for diabetes. Expert Opin Investig Drugs 21: 45-57, 2012.
8. Davidson JA: Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors. Cleve Clin J Med 76 (Suppl 5): S28-S38, 2009
9. Lorber D: GLP-1 receptor agonists: effects on cardiovascular risk reduction. Cardiovasc Ther: Jul 30, 2012 (Epub ahead of print).
10. Mundil D, Cameron-Vendrig A and Husain M: GLP-1 receptor agonists: a clinical perspective on cardiovascular effects. Diab Vasc Dis Res 9: 95-108, 2012.
11. Chiquette E, Toth PP, Ramirez G, Cobble M and Chilton R: Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers. Vasc Health Risk Manag 8: 621-629, 2012.
12. Timmers L, Henriques JP, de Kleijn DP, Devries JH, Kemperman H, Steendijk P, Verlaan C.W., Kerver M., Piek JJ, Doevendans PA, Pasterkamp G and Hoef er IE: Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol 53: 501-510, 2009
13. Laviola L, Leonardini A, Melchiorre M., Orlando MR, Peschechera A, Bortone A, Paparella D., Natalicchio A, Perrini S and Giorgino F: Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology 153: 5770-5781, 2012.
14. Ravassa S, Zudaire A, Carr RD and Díez J: Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytes. Am J Physiol Heart Circ Physiol 300: H1361-H372, 2011.
15. Younce CW, Burmeister MA and Ayala JE: Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol 304: C508-C518, 2013.
16. 2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Biochim Biophys Acta 1820: 907-920, 2012.
17. Fishbein MC, Meerbaum S, Rit J., Lando U, Kanmatsuse K, Mercier J.C., Corday E and Ganz W: Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J 101:593-600, 1981.
18. Loesser KE, Kukreja RC, Kazziha S.Y., Jesse RL and Hess ML: Oxidative damage to the myocardium: a fundamental mechanism of myocardial injury. Cardioscience 2: 199-216, 1991.
19. Suzuki K, Murtuza B, Sammut I.A., Latif N et al.: Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 106: I270-I276, 2002.
20. Peng X and Li Y: Induction of cellular glutathione-linked enzymes and catalase by the unique chemoprotective agent, 3H-1, 2-dithiole-3-thione in rat cardiomyocytes affords protection against oxidative cell injury. Pharmacol Res 45: 491-497, 2002.
21. Li C, Liu Z, Tian J., Li G, Jiang W, Zhang G., Chen F, Lin P and Ye Z: Protective roles of Asperosaponin VI, a triterpenesaponin isolated from Dipsacusasper Wall on acute myocardial infarction in rats. Eur J Pharmacol 627: 235-241, 2010.
22. Li J, Shao ZH, Xie J.T., Wang CZ, Ramachandran S, Yin JJ, Aung H, Li C.Q., Qin G., Vanden Hoek T and Yuan CS: The effects of ginsenoside Rb1 on JNK in oxidative injury in cardio-myocytes. Arch Pharm Res 35: 1259-1267, 2012.
23. Jin HB, Yang YB, Song Y.L., Zhang YC and Li YR: Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats. Mol Biol Rep 39: 11005-11009, 2012.
24. Cai Y, Hu X, Yi B., Zhang T and Wen Z: Glucagon-like peptide-1 receptor agonist protects against hyperglycemia-induced cardiocytes injury by inhibiting high mobility group box 1 expression. Mol Biol Rep 39: 10705-10711, 2012.
25. Fontes JP, Gonçalves M and Ribeiro VG: Serum markers for ischemic myocardial damage. Rev Port Cardiol 18: 1129-1136, 1999 (Portuguese).
26. Xie Y, Wang SX, Sha W.W., Zhou X., Wang WL, Han LP, Li DQ and Yu DM: Effects and mechanism of glucagon-like peptide-1 on injury of rats cardiomyocytes induced by hypoxia-reoxy-genation. Clin Med J 121: 2134-2138, 2008.
27. Chinda K, Chattipakorn S and Chattipakorn N: Cardioprotective effects of incretin during ischaemia-reperfusion. Diab Vasc Dis Res 9: 256-269, 2012.
28. Khalil PN, Neuhof C, Huss R., Pollhammer M, Khalil MN, Neuhof H, Fritz H and Siebeck M: Calpain inhibition reduces infarct size and improves global hemodynamics and left ventricular contractility in a porcine myocardial ischemia/reper-fusion model. Eur J Pharmacol 528:124-131, 2005.
29. Hausenloy DJ and Yellon DM: New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury s alvage kinase (RISK)-pathway. Cardiovasc Res 61: 448-460, 2004.
30. Mullonkal CJ and Toledo-Pereyra LH: Akt in ischemia and reperfusion. J Invest Surg 20: 195-203, 2007.
31. Fujio Y, Nguyen T, Wencker D., Kitsis RN and Walsh K: Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667, 2000.
32. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M., Force TL, Franke TF, Hajjar RJ and Rosenzweig A: Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104: 330-335, 2001.