Exenatide reduces tumor necrosis factor-α-induced apoptosis in cardiomyocytes by alleviating mitochondrial dysfunction

Chinese Medical Journal

Volumn 128, Issue 23, 2015, Pages 3211-3218

  Cao, Yuan Yuan ^a   Chen, Zhang Wei ^a   Gao, Yan Hua ^a   Wang, Xing Xu ^a   Ma, Jian Ying ^a   Chang, Shu Fu ^a   Qian, Ju Ying ^a   Ge, Jun Bo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cell Apoptosis; Glucagon like Peptide 1; Mitochondrial function; Oxidative stress; Tumor necrosis factor

Indexed keywords

CASPASE 3; CYTOCHROME C; EXENDIN 4; FLUORESCENT DYE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; PEPTIDE; TUMOR NECROSIS FACTOR; VENOM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEART MUSCLE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; CARDIAC MUSCLE CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; METABOLISM; MITOCHONDRION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TUMOR NECROSIS FACTOR-ALPHA; VENOMS;

EID: 84949008539     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.4103/0366-6999.170259     Document Type: Article

References (26)

1. Moe GW, Marin-Garcia J, Konig A, Goldenthal M, Lu X, Feng Q. In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am J Physiol Heart Circ Physiol 2004;287:1813-20.
2. Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U S A 1992;89:8641-5.
3. Timmers L, Henriques JP, de Kleijn DP, Devries JH, Kemperman H, Steendijk P, et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol 2009;53:501-10.
4. Chang G, Zhang D, Liu J, Zhang P, Ye L, Lu K, et al. Exenatide protects against hypoxia/reoxygenation-induced apoptosis by improving mitochondrial function in H9c2 cells. Exp Biol Med (Maywood) 2014;239:414-22.
5. Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009;58:975-83.
6. Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109:962-5.
7. Lønborg J, Vejlstrup N, Kelbæk H, Bøtker HE, Kim WY, Mathiasen AB, et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J 2012;33:1491-9.
8. Simpson P, Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res 1982;50:101-16.
9. Skyschally A, Gres P, Hoffmann S, Haude M, Erbel R, Schulz R, et al. Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: Progressive contractile dysfunction versus delayed protection against infarction. Circ Res 2007;100:140-6.
10. Schulz R, Aker S, Belosjorow S, Heusch G. TNFalpha in ischemia/reperfusion injury and heart failure. Basic Res Cardiol 2004;99:8-11.
11. Chen ZW, Qian JY, Ma JY, Chang SF, Yun H, Jin H, et al. TNF-a-induced cardiomyocyte apoptosis contributes to cardiac dysfunction after coronary microembolization in mini-pigs. J Cell Mol Med 2014;18:1953-63.
12. Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T, et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation 1998;98:794-9.
13. Al-Shudiefat AA, Sharma AK, Bagchi AK, Dhingra S, Singal PK. Oleic acid mitigates TNF-a-induced oxidative stress in rat cardiomyocytes. Mol Cell Biochem 2013;372:75-82.
14. Mariappan N, Soorappan RN, Haque M, Sriramula S, Francis J. TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: Restoration by superoxide dismutase mimetic Tempol. Am J Physiol Heart Circ Physiol 2007;293:2726-37.
15. Sinagra E, Perricone G, Romano C, Cottone M. Heart failure and anti tumor necrosis factor-alpha in systemic chronic inflammatory diseases. Eur J Intern Med 2013;24:385-92.
16. Peters MJ, van Sijl AM, Voskuyl AE, Sattar N, Smulders YM, Nurmohamed MT. The effects of tumor necrosis factor inhibitors on cardiovascular risk in rheumatoid arthritis. Curr Pharm Des 2012;18:1502-11.
17. Javed Q, Murtaza I. Therapeutic potential of tumour necrosis factor-alpha antagonists in patients with chronic heart failure. Heart Lung Circ 2013;22:323-7.
18. Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, et al. Glucagon-like peptide (GLP)-1 (9-36) amide-mediated cytoprotection is blocked by exendin (9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010;151:1520-31.
19. Hamacher-Brady A, Stein HA, Turschner S, Toegel I, Mora R, Jennewein N, et al. Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem 2011;286:6587-601.
20. Orrenius S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev 2007;39:443-55.
21. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6:513-9.
22. Antignani A, Youle RJ. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 2006;18:685-9.
23. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003;304:437-44.
24. de Jong R, van Hout GP, Houtgraaf JH, Kazemi K, Wallrapp C, Lewis A, et al. Intracoronary infusion of encapsulated glucagon-like peptide-1-eluting mesenchymal stem cells preserves left ventricular function in a porcine model of acute myocardial infarction. Circ Cardiovasc Interv 2014;7:673-83.
25. Woo JS, Kim W, Ha SJ, Kim JB, Kim SJ, Kim WS, et al. Cardioprotective effects of exenatide in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Results of exenatide myocardial protection in revascularization study. Arterioscler Thromb Vasc Biol 2013;33:2252-60.
26. Nathanson D, Ullman B, Löfström U, Hedman A, Frick M, Sjöholm A, et al. Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: A double-blind, randomised controlled clinical trial of efficacy and safety. Diabetologia 2012;55:926-35.