Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

Nature Biotechnology

Volumn 35, Issue 1, 2017, Pages 56-68

  Protze, Stephanie I ^a,b   Liu, Jie ^c,d   Nussinovitch, Udi ^e   Ohana, Lily ^c,d   Backx, Peter H ^c,d   Gepstein, Lior ^e   Keller, Gordon M ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c YORK UNIVERSITY   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATA THEORY; BIOELECTRIC POTENTIALS; CARDIOVASCULAR SYSTEM; CELLS; CYTOLOGY; ELECTROPHYSIOLOGY; HEART; MOLECULAR BIOLOGY; PACEMAKERS; STEM CELLS;

ACTION POTENTIALS; BLOOD CIRCULATION; CARDIOMYOCYTES; CELL TRANSPLANTATION; HOST TISSUES; PLURIPOTENT STEM CELLS; SIGNALING PATHWAYS; SINOATRIAL NODE;

CELL SIGNALING;

BONE MORPHOGENETIC PROTEIN 4; HOMEOBOX PROTEIN NKX-2.5;

ARTICLE; BIOLOGICAL FUNCTIONS; CARDIAC MUSCLE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL SELECTION; CELL TRANSPLANTATION; CONTROLLED STUDY; ELECTRIC ACTIVITY; ELECTROCARDIOGRAM; FLOW CYTOMETRY; FREQUENCY; HUMAN; HUMAN CELL; PACEMAKER; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINOATRIAL NODE LIKE PACEMAKER CELL; SINUS NODE; UPREGULATION; ACTION POTENTIAL; BIOLOGICAL RHYTHM; CELL CULTURE; CELL LINE; CYTOLOGY; GENETIC ENGINEERING; PHYSIOLOGY;

ACTION POTENTIALS; BIOLOGICAL CLOCKS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; GENETIC ENGINEERING; HUMANS; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; SINOATRIAL NODE;

EID: 85011032595     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3745     Document Type: Article

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