A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers

Ophthalmology

Volumn 124, Issue 4, 2017, Pages 505-511

  Vehof, Jelle ^a,b   Hysi, Pirro G ^a   Hammond, Christopher J ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 ANDROSTEN 3BETA 17BETA DIOL DISULFATE; 4 ANDROSTENEDIOL; ANDROGEN; ANDROSTERONE SULFATE; EPIANDROSTERONE; EPIANDROSTERONE SULFATE; PRASTERONE SULFATE; UNCLASSIFIED DRUG; 4-ANDROSTENE-3,17-DIOL; ANDROSTENEDIOL DERIVATIVE; ANDROSTERONE; BIOLOGICAL MARKER;

ADULT; ANDROGEN BLOOD LEVEL; ANDROGEN METABOLISM; ARTICLE; BODY MASS; CONTROLLED STUDY; DRY EYE; EYE IRRITATION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MIDDLE AGED; PRIORITY JOURNAL; ADOLESCENT; AGED; ANALOGS AND DERIVATIVES; BLOOD; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DRY EYE SYNDROMES; MASS FRAGMENTOGRAPHY; QUESTIONNAIRE; RISK FACTOR; TWINS; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANDROGENS; ANDROSTENEDIOLS; ANDROSTERONE; BIOMARKERS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; DRY EYE SYNDROMES; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; METABOLOME; MIDDLE AGED; RISK FACTORS; SURVEYS AND QUESTIONNAIRES;

EID: 85010943847     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2016.12.011     Document Type: Article

References (31)

1. 1 Dry Eye Workshop. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5 (2007), 75–92.
2. 2 Dry Eye Workshop. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 5 (2007), 93–107.
3. 3 Hunter, P., Reading the metabolic fine print. The application of metabolomics to diagnostics, drug research and nutrition might be integral to improved health and personalized medicine. EMBO Rep 10 (2009), 20–23.
4. 4 Psychogios, N., Hau, D.D., Peng, J., et al. The human serum metabolome. PLoS One, 6, 2011, e16957.
5. 5 Tan, S.Z., Begley, P., Mullard, G., et al. Introduction to metabolomics and its applications in ophthalmology. Eye (Lond) 30 (2016), 773–783.
6. 6 Moayyeri, A., Hammond, C.J., Hart, D.J., Spector, T.D., The UK Adult Twin Registry (TwinsUK Resource). Twin Res Hum Genet 16 (2013), 144–149.
7. 7 Andrew, T., Hart, D.J., Snieder, H., et al. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4 (2001), 464–477.
8. 8 Gulati, A., Sullivan, R., Buring, J.E., et al. Validation and repeatability of a short questionnaire for dry eye syndrome. Am J Ophthalmol 142 (2006), 125–131.
9. 9 Menni, C., Kastenmuller, G., Petersen, A.K., et al. Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol 42 (2013), 1111–1119.
10. 10 Labrie, F., Belanger, A., Cusan, L., et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metabol 82:8 (1997), 2396–2402.
11. 11 El Kihel, L., Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)–recent reports. Steroids 77 (2012), 10–26.
12. 12 Truong, S., Cole, N., Stapleton, F., Golebiowski, B., Sex hormones and the dry eye. Clin Exp Optom 97 (2014), 324–336.
13. 13 Sullivan, D.A., Sullivan, B.D., Evans, J.E., et al. Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye. Ann N Y Acad Sci 966 (2002), 211–222.
14. 14 Sullivan, D.A., Sullivan, B.D., Ullman, M.D., et al. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci 41 (2000), 3732–3742.
15. 15 Cermak, J.M., Krenzer, K.L., Sullivan, R.M., et al. Is complete androgen insensitivity syndrome associated with alterations in the meibomian gland and ocular surface?. Cornea 22:6 (2003), 516–521.
16. 16 Knop, E., Knop, N., Millar, T., et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci 52:4 (2011), 1938–1978.
17. 17 Sullivan, D.A., Belanger, A., Cermak, J.M., et al. Are women with Sjogren's syndrome androgen-deficient?. J Rheumatol 30 (2003), 2413–2419.
18. 18 Labrie, F., Belanger, A., Cusan, L., Candas, B., Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metabol 82:8 (1997), 2403–2409.
19. 19 Bizzarro, A., Valentini, G., Di Martino, G., et al. Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome. J Clin Endocrinol Metabol 64:1 (1987), 32–36.
20. 20 Golebiowski, B., Badarudin, N., Eden, J., et al. The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study. Br J Ophthalmol, 2016 Nov 3 pii: bjophthalmol-2016-309498. http://dx.doi.org/10.1136/bjophthalmol-2016-309498. [Epub ahead of print].
21. 21 Nanavaty, M.A., Long, M., Malhotra, R., Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. Br J Ophthalmol 98 (2014), 567–569.
22. 22 Worda, C., Nepp, J., Huber, J.C., Sator, M.O., Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 37 (2001), 209–212.
23. 23 Scott, G., Yiu, S.C., Wasilewski, D., et al. Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. Am J Ophthalmol 139 (2005), 1109–1110.
24. 24 Krenzer, K.L., Dana, M.R., Ullman, M.D., et al. Effect of androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocrinol Metab 85 (2000), 4874–4882.
25. 25 Forsblad-d'Elia, H., Carlsten, H., Labrie, F., et al. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. J Clin Endocrinol Metab 94 (2009), 2044–2051.
26. 26 Pillemer, S.R., Brennan, M.T., Sankar, V., et al. Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjogren's syndrome. Arthritis Rheum 51 (2004), 601–604.
27. 27 Galbis-Estrada, C., Martinez-Castillo, S., Morales, J.M., et al. Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy. Biomed Res Int 2014 (2014), 542–549.
28. 28 Galbis-Estrada, C., Pinazo-Duran, M.D., Martinez-Castillo, S., et al. A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids. Mol Vis 21 (2015), 555–567.
29. 29 Chen, L.Y., Li, J., Guo, T.N., et al. Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress. J Proteome Res 14 (2015), 3982–3995.
30. 30 Vehof, J., Zavos, H.M., Lachance, G., et al. Shared genetic factors underlie chronic pain syndromes. Pain 155 (2014), 1562–1568.
31. 31 Livshits, G., Macgregor, A.J., Gieger, C., et al. An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker. Pain 156 (2015), 1845–1851.